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4 results on '"V, Beckers"'

1. [Prolonged treatment with recombined growth hormone improves bone measures: study of body composition in 21 deficient adults on treatment]

Author

V, Beckers, J, Milet, and J J, Legros

Subjects
Adult, Male, Time Factors, Adolescent, Bone and Bones, Hypopituitarism, Absorptiometry, Photon, Bone Density, Humans, Insulin-Like Growth Factor I, Child, Muscle, Skeletal, Aged, Hypophysectomy, Minerals, Human Growth Hormone, Infant, Newborn, Middle Aged, Water-Electrolyte Balance, Hormones, Recombinant Proteins, Adipose Tissue, Body Composition, Drug Evaluation, Female, Follow-Up Studies
Abstract

Adult growth hormone deficiency is characterized by changes in body composition: increase in total fat, decrease in lean mass and osteopenia, with a fall in Bone Mineral Content (BMC) and in Bone Mineral density (BMD) leading to a rise in risk of fracture. We have analyzed the changes in body composition in 21 adults treated from 9 to 78 months, by dual X-RAY absorptiometry (DEXA). We've demonstrated a gain in bone mass and density, particularly of axial skeleton; a latence of minimum 12 months has been necessary to objective these changes. The balance of fat and lean mass has been poorly modified by treatment except for the lean mass of the trunk, which is significantly increased. We think that the usual doses of rGH, based on IGF-1 level, are perhaps underestimated.

Published
2002

3. [Prolonged treatment with recombined growth hormone improves bone measures: study of body composition in 21 deficient adults on treatment].

Author

Beckers V, Milet J, and Legros JJ

Subjects
Absorptiometry, Photon, Adipose Tissue drug effects, Adipose Tissue pathology, Adolescent, Adult, Aged, Body Composition drug effects, Bone and Bones chemistry, Bone and Bones pathology, Child, Drug Evaluation, Female, Follow-Up Studies, Hormones blood, Human Growth Hormone administration & dosage, Human Growth Hormone deficiency, Humans, Hypophysectomy adverse effects, Hypopituitarism etiology, Hypopituitarism metabolism, Hypopituitarism pathology, Infant, Newborn, Insulin-Like Growth Factor I analysis, Male, Middle Aged, Minerals analysis, Muscle, Skeletal pathology, Recombinant Proteins administration & dosage, Recombinant Proteins therapeutic use, Time Factors, Water-Electrolyte Balance, Bone Density drug effects, Human Growth Hormone therapeutic use, Hypopituitarism drug therapy
Abstract

Adult growth hormone deficiency is characterized by changes in body composition: increase in total fat, decrease in lean mass and osteopenia, with a fall in Bone Mineral Content (BMC) and in Bone Mineral density (BMD) leading to a rise in risk of fracture. We have analyzed the changes in body composition in 21 adults treated from 9 to 78 months, by dual X-RAY absorptiometry (DEXA). We've demonstrated a gain in bone mass and density, particularly of axial skeleton; a latence of minimum 12 months has been necessary to objective these changes. The balance of fat and lean mass has been poorly modified by treatment except for the lean mass of the trunk, which is significantly increased. We think that the usual doses of rGH, based on IGF-1 level, are perhaps underestimated.

Published
2001

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