1. PREPARATION DE L'ACIDE AMINOMETHYLPHOSPHONIQUE α-DIDEUTERIE
- Author
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Carl Patois Et, Philippe Savignac, Sylvie Berté-Verrando, François Nief, Laboratoire Hétéroéléments et Coordination (DCPH), and École polytechnique (X)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
chemistry.chemical_element ,deuterium oxide ,aminomethylphosphonic acid ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,trifluoroethanol ,Inorganic Chemistry ,chemistry.chemical_compound ,Hydrolysis ,chloromethylphosphonic esters ,Nucleophile ,sodium azide ,Chlorine ,Organic chemistry ,Aminomethylphosphonic acid ,α-dideuteriated aminomethylphosphonic acid ,Amination ,010405 organic chemistry ,[CHIM.ORGA]Chemical Sciences/Organic chemistry ,Organic Chemistry ,α-dideuteriated chloromethyl-phosphonic esters ,0104 chemical sciences ,nucleophilic amination ,chemistry ,Deuterium ,Sodium azide ,Azide - Abstract
International audience; Nucleophilic amination of chloromethylphosphonic esters was studied. α-Dideuteriared aminomethyl-phosphonic acid was obtained from bis(trifluoroethyl) chloromehylphosphonic ester and sodium azide through substitution of the chlorine, reduction of the azide and acidic hydrolysis. Incorporation of the deuterium was greater than 95% and overall yields were in the range 55-65%.
- Published
- 1995
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