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To comprehensively analyze the stability of the chemical quality of tobacco leaf in Honghe State, and to provide a basis for finding ways to narrow the difference between tobacco leaf quality in Honghe State and maintaining the stability of the quality of tobacco leaves in the tobacco producing area. Statistics were used to analyze the annual stability of Honghe tobacco leaves and the stability of the tobacco planting range from 2014 to 2017. The chemical quality of Honghe tobacco leaves was not stable in different years, the total sugar and reduced sugar content showed the trend of decreasing year by year, in addition, the potassium and chlorine content of the tobacco leaves in this tobacco planting area had been at a low level for four consecutive years. In 2014 - 2017, the total sugar, reduced sugar and chlorine content of the tobacco leaves in Honghe State were all relatively small, while the variation coefficient values of nicotine and potassium content in tobacco leaves were large, while the chlorine content in tobacco leaves was extremely unstable between years. For four consecutive years, the chemical quality of tobacco leaves in seven tobacco - planting counties and cities in Honghe State was significant. The chemical quality of tobacco leaves in Honghe State was unstable between different counties and cities.