1. [Increase of circulating CD3+CD4-CD8-CD19+ cells in the latent phase of HIV-1 infection]
- Author
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J, Nozaki-Renard, J, O'Leary, S, Zolla-Pazner, and T, Tada
- Subjects
CD3 Complex ,CD8 Antigens ,Integrin beta1 ,T-Lymphocytes ,HIV Infections ,Flow Cytometry ,Cell Line ,Immunophenotyping ,Virus Latency ,Antigens, CD ,T-Lymphocyte Subsets ,CD4 Antigens ,HIV Seropositivity ,HIV-1 ,Humans - Abstract
Having reported that HIV-1-infected T cell lines are rescued as CD4- from cytolysis by human complement factor B, we now show the presence of an in vivo counterpart of such CD4- T cells by demonstrating the circulating CD3+ CD4- CD8- CD29+ cells in the blood of seropositive subjects (n = 91, classified by the immunologic scale scores 0, 1, 2 and 3). The cell population was found to be significantly increased in the early phase of infection in score 0: 195/mm3 (p0.005) and in score 1:376/mm3 (p = 0.001). With the infection progressing to score 2, the cells decreased to 220/mm3 (p0.001) and finally to the same range: 101/mm3, as that of uninfected subjects. Further elucidation of the mechanism of the appearance and disappearance of that population in vivo could help to elucidate protective immunologic processes.
- Published
- 1999