Search

The paper provides literature review on the relationship among climatic conditions, ecological characteristics of the stable fly (Stomoxys calcitrans L.) and the observed spread of lumpy skin disease across the Russian Federation in 2015-2019. This study was carried out to gain an insight into a role of this potential vector in LSDV transmission. Data analysis shows that the flight activity of the stable fly mainly fits into the seasonal pattern of LSD outbreaks. However, there were outbreaks that occurred outside the period of the stable fly flight activity, pointing to other routes of transmission.

Affective disorders are widespread among student youth. Anxiety and depression are the most common disorders, but thorough diagnostics reveals other emotional disturbances as well, which may imply bipolar disorder (BD). BD is associated with a wide range of adverse outcomes; therefore, it is important to identify masking symptoms that predict the onset and course of BD. One of the predictors of bipolar disorder is the temperament. The present study aimed to analyze the entire spectrum of affective disorders and determine the correlation between them and the affective temperaments. The study involved 106 medical students. They completed the following autoquestionnaires: PHQ-9, ASRM, GAD-7, ShARS, HCL-32 and TEMPS-A. Conducting analyses, the results of the HCL-32 questionnaire were statistically significantly correlating with the results of GAD-7 (p = 0.034) and the hyperthymic (p = 0.000), cyclothymic (p = 0.000) and excitable (p = 0.004) temperaments according to TEMPS-A. When dividing the total sample into two groups, based on the HCL-32 questionnaire data, a higher incidence of depressive disorders on the PHQ-9 scale (p = 0.023) was found among respondents who scored more than 14 points on the HCL-32. Almost half of the respondents showed a high level of hypomania, which implies a high risk of developing bipolar spectrum disorders. A statistically significant relationship between hypomania and personality traits was found with hyperthymic, cyclothymic and excitable temperaments. It is necessary to diagnose such disorders in time to improve the social functioning of the students.

Abstract Background Independent studies have shown that several single nucleotide polymorphisms (SNP) in the human FTO (fat mass and obesity associated) gene are associated with obesity. SNP have also been identified in the pig FTO gene, among which some are associated with selected fat-deposition traits in F2 crosses and commercial populations. In this study, using both commercial pig populations and an experimental Meishan × Pietrain F2 population, we have investigated the association between one FTO SNP and several growth and carcass traits. Association analyses were performed with the FTO polymorphism either alone or in combination with polymorphisms in flanking loci. Methods SNP (FM244720:g.400C>G) in exon 3 of porcine FTO was genotyped by PCR-RFLP and tested for associations with some growth, carcass and fat-related traits. Proportions of genetic variance of four pig chromosome 6 genes (FTO, RYR1, LIPE and TGFB1) on selected traits were evaluated using single- and multi-locus models. Results Linkage analysis placed FTO on the p arm of pig chromosome 6, approximately 22 cM from RYR1. In the commercial populations, allele C of the FTO SNP was significantly associated with back fat depth and allele G with muscling traits. In the Meishan × Pietrain F2 pigs, heterozygotes with allele C from the Pietrain sows and allele G from the Meishan boar were more significantly associated with fat-related traits compared to homozygotes with allele G from the Pietrain and allele G from the Meishan breed. In single- and multi-locus models, genes RYR1, TGFB1 and FTO showed high associations. The contribution in genetic variance from the polymorphism in the FTO gene was highest for back fat depth, meat area on the musculus longissimus lumborum et thoracis tissues and metabolite glucose-6-phosphate dehydrogenase. Conclusions Our results show that in pig, FTO influences back fat depth in the commercial populations, while in the Meishan × Pietrain F2 pigs with a CG genotype, heterosis occurs for several fat-related traits.