1. [Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils].
- Author
-
Spinnewyn B, Blavet N, and Clostre F
- Subjects
- Animals, Brain drug effects, Brain metabolism, Brain Ischemia etiology, Brain Ischemia metabolism, Drug Evaluation, Preclinical, Mitochondria drug effects, Mitochondria metabolism, Nicergoline therapeutic use, Oxygen Consumption drug effects, Plant Extracts therapeutic use, Vincamine therapeutic use, Brain Ischemia drug therapy, Disease Models, Animal, Gerbillinae, Plants, Medicinal, Trees
- Abstract
Certain anatomical characteristics peculiar to the gerbil make it the animal model best adapted to experimental pathology studies of acute ischaemia. In this animal species, devoid of any substitute vertebro-basilar vascular tissue, unilateral ligature of the carotid artery produces a cerebral ischaemia with neurological signs (well quantifiable), metabolic perturbations (especially mitochondrial) and cerebral oedema development closely resembling the symptoms revealed by physiopathology in human clinical studies. Using this model and under the experimental conditions described, clear-cut, highly significant results were obtained with Ginkgo biloba, whether by oral or intravenous administration. These results were normalization of mitochondrial respiration, diminution of cerebral oedema, correction of the accompanying ionic perturbations, and practically total functional restoration revealed by a normal neurological index in the gerbils treated with Ginkgo biloba extract.
- Published
- 1986