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Your search keyword '"Siala, Nadia"' showing total 3 results
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3 results on '"Siala, Nadia"'

1. Neonatal-onset Progressive Familial Intrahepatic Cholestasis (PFIC): first molecular study in Tunisian patients

Author

Selmi, Ines, Broly, Franck, Ouarda, Haifa, Marmech, Emna, Khlayfia, Zied, Kanzari, Jihed, Azzabi, Ons, Siala, Nadia, Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), and Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
Intrahepatic, Cholestasis, [SDV]Life Sciences [q-bio], Mutation, Infant, Newborn, Humans, Infant, Cholestasis, Intrahepatic, Newborn, Article
Abstract

International audience; Progressive familial intrahepatic is a heterogeneous group of rare autosomal recessive liver disorders. Neonatal onset is characteristic of the PFIC 1 and PFIC 2, which result from mutations in genes respectivelyATP8B1 and ABCB11. Four Tunisian patients, three of them with PFIC 2 and one with PFIC1, were described. They all had typical clinical and biological features. However, they all had newly reported mutations. The same mutation was found in the patients with PFIC2, which could facilitate the diagnosis in Tunisian patients suspected in the future. The patient diagnosed with PFIC1 had also a newly described mutation, with a probable phenotypic particularity that is congenital hypothyroidism. Advances are being made to establish a molecular diagnosis in neonatal onset cholestasis. Indeed, next generation sequencing gene panels (NGSGP) potentially decrease the need for invasive procedures in these patients, enable early initiation of treatment and adequate genetic counseling.

Published
2021

2. Tunisian consensus on the management of Helicobacter Pylori infection.

Author

Medhioub M, Chtourou L, Kchaou M, Khsiba A, Zakhama M, Ben Ameur W, Moalla M, Yacoub H, Ayadi S, Bouchabou B, Battikh H, Zribi M, Siala N, Azouz MM, Amouri A, Abdelli MN, Safer L, Bibani N, Ben Mustapha N, Hammami A, Abdelwaheb M, Ennaifer R, Jomni T, and Fekhi M

Subjects
Humans, Consensus, Anti-Bacterial Agents therapeutic use, Duodenum, Helicobacter Infections complications, Helicobacter Infections diagnosis, Helicobacter Infections epidemiology, Helicobacter pylori
Abstract

Helicobacter pylori infection is the most common infectious disease worldwide. It is associated with duodenal and gastric ulcer disease and the risk of gastric neoplasia. The management of helicobacter pylori infection currently represents a real challenge for clinicians, given the ever-increasing rate of resistance of Helicobacter pyolori to various antibiotics. In this consensus document, we present recommendations adapted to the Tunisian context, including indications for the detection of helicobacter pylori infection, indications for the use of different diagnostic methods, and a therapeutic strategy for the management of Helicobacter pylori infection.

Published
2023

3. [The hydatid cyst of the lung in children: 54 cases].

Author

Boussetta K, Siala N, Brini I, Aloui N, Sammoud A, Hammou A, Chaouachi B, and Bousnina S

Subjects
Adolescent, Child, Child, Preschool, Echinococcosis, Pulmonary epidemiology, Echinococcosis, Pulmonary surgery, Female, Humans, Male, Retrospective Studies, Tunisia epidemiology, Echinococcosis, Pulmonary diagnosis
Abstract

The purpose of this retrospective study is to clarify the clinical, radiological and evolutionary aspects of the hydatid cyst of the lung. Over a period of 9 years (January, 1983 - December, 2001), we brought together in the pediatric service B of Children's hospital of Tunis, 54 cases of hydatid cyst of the lung. The average age is of 7 years 3 months (extremes 2 and 14 years), and the sex- ratio of 1,16. 61% of the children are of rural origin. Bronchpulmonary infection is the most frequent circumstance of discovery (72 % of cases). hemoptysis is revealing in 37% of cases. Discovery is fortuitous in 7% of cases. The radiography of the chest is of a big diagnostic contribution. The radiological aspects obtained are: a homogeneous opaqueness (61%), a diverse opaqueness (26%), an image of lung abscess (22 %), an aspect of floating membrane (4 %), a pleural effusion (9%), and an opaqueness with growing gas (4%). Chest echography was contributory in 77% of cases. 74% of the children were operated without complications. The others were lost.

Published
2005

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