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1. [Peripheral neuropathy in Waldenstrom's macroglobulinemia. Antibody activity of monoclonal immunoglobulin M directed against vimentin].

Author

Dellagi K, Chedru F, Clauvel JP, and Brouet JC

Subjects
Antibodies, Monoclonal immunology, Humans, Male, Middle Aged, Peripheral Nervous System Diseases immunology, Peripheral Nervous System Diseases therapy, Plasma Exchange, Schwann Cells immunology, Vimentin, Waldenstrom Macroglobulinemia immunology, Autoantibodies immunology, Immunoglobulin M immunology, Intermediate Filament Proteins immunology, Peripheral Nervous System Diseases etiology, Waldenstrom Macroglobulinemia complications
Abstract

In two patients with Waldenström's macroglobulinaemia complicated with peripheral neuropathy, purified monoclonal immunoglobulin M showed antibody activity specifically directed against vimentin, a major polypeptide of mesenchymal cell cytoskeleton and therefore in Schwann's cell. The neuropathy was of the sensory-motor type. It was improved in one case by plasma exchanges combined with chemotherapy. The relevance of this original antibody activity to the pathogenesis of neuropathy is discussed.

Published
1984

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