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Résumé Les auteurs présentent une analyse rétrospective des déclarations d’anaphylaxie grave effectuées par les médecins spécialistes allergologues belges sur le Réseau français allergo-vigilance de 2011 à 2012. En l’absence de registre national, les données partielles analysées révèlent que leur prise en charge immédiate reste insuffisante quant à l’évaluation de la sévérité, au délai d’administration d’adrénaline, aux conditions de transport vers les urgences et au temps de surveillance en salle d’urgence quel que soit l’âge des patients. Créer un registre national d’anaphylaxies permettrait d’évaluer régulièrement et ainsi améliorer la qualité de la prise en charge ; il constituerait également une bonne base de données et servirait d’outil pour des études épidémiologiques. The authors present a retrospective analysis of reports of severe anaphylactic reactions made by Belgian allergists to the French Allergy Vigilance Network from 2011 to 2012. In the absence of a national anaphylaxis registry in Belgium, an incomplete analysis of the available data revealed that immediate management of the cases was inadequate with respect to evaluation of the severity of the reaction, the delay in administration of adrenalin, details of the patients’ transport to an Emergency Room, and the duration under medical observation in the Emergency Room, whatever the patients’ age. Creation of a national anaphylaxis registry would provide a means for regular evaluation and thus could lead to improvement in the quality of the management; it would also form an excellent data bank, which could serve as a tool for epidemiological studies. [ABSTRACT FROM AUTHOR]

Ambulatory gynecological surgery enables fast recovery of vital functions, ambulation and a relational life of quality. Patients whose disease is well-controlled at the anesthesia consultation can benefit from ambulatory procedures. Improved material and surgical practices broaden potential indications, limiting the risk of postoperative pain which can be controlled with simple analgesic protocols. The choice of the anesthesic techniques or the agents used during the intervention ensures fast recovery of higher functions. Nausea and vomiting, which may develop after returning home and compromise oral drug intake, must be prevented. More ambulatory gynecological procedures can be expected in the near future, pointing out the importance of developing more adapted medical structures.

We propose a method to study the primary stability and the periacetabular deformation under static load, with and without cemented and cement-free acetabular implants, using a biomechanical model that stimulates the balance mechanism described by Pauwels. The biomechanical model uses whole pelvises of recently frozen corpses. We have imitated the gluteus medius and minimus muscles on the pelvis with cables and pulleys. The loading device comprises a metallic frame, on which a hydraulic press is set up for static testing, and a prototype femoral prosthesis made of two main parts: one on which the gluteal muscles are inserted, and another one on which the femoral head is attached. The pelvis is fixed to the metallic frame by a plate attached to the sacrum and allowing movements in all planes of space. The measurement method utilizes: for primary stability, four transducers, including three three-directional ones, in the three planes of space outside the pelvis, only one being located inside the pelvis with a 16 degrees orientation relative to the vertical; for deformation, a transducer located in three different places in the periacetabular region. We have used ten freshly frozen pelvises with six different implants (two with and four without cement) and eighteen implantations.

Citrulline production is demonstrated in murine bone marrow cell cultures incubated with dialyzed secondary MLC supernatant. This synthesis, proceeding from arginine, is induced by a soluble protein factor released during secondary MLC, unstable to heat, with a molecular weight of approximately 150,000 daltons.

Since homogeneously purified Interleukin 3 can induce an increase in histamine synthesis by normal bone marrow cells (HCSF activity), it has been suggested that HCSF and IL3 could be identical. In this paper, we show evidence that HCSF activity can be obtained without any IL3 activity (determined by the proliferation of an IL3-dependent cell line). This distinction has been achieved in two different ways: (a) the physico-chemical separation of HCSF and IL3 from crude secondary MLC supernatants and (b) the spontaneous production by the P388D1 cell line of a factor possessing all the characteristics of HCSF without any IL3 activity. In addition, preliminary results show that anti-IL3 antibodies do not inhibit the increase in histamine synthesis induced by HCSF while it strongly diminishes that induced by IL3.

This paper reviews our actual knowledge on Buerger's disease, a segmental inflammatory processors of peripheral, medium sized arteries and veins, and includes 33 patients of our clinic. In more than 50 p. 100 of cases antielastin antibodies were increased and the complement factor C4 decreased. 23 p. 100 had circulating immune complexes. Clinical experience and these immunological findings suggest medical treatment by antiinflammatory drugs like aspirin at relatively high doses or indomethazine. In resistant cases prednisone and azathioprine can suppress the activity of disease. If a limb is threatened by amputation the eventual implantation of a femoro-crural or cruro-crural bypass should be discussed.