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The Mannich reaction is a three-component reaction of an aldehyde, a primary or secondary amine and a ketone which is one of the most powerful C-C bond forming reactions in organic synthesis. It leads to β-amino carbonyl compounds, which are useful for the syntheses of nitrogen containing compounds, such as natural products and medicinally relevant compounds. The versatility and potential of these compounds to introduce both functional and structural diversity using the Mannich reaction have stimulated the creativity of chemists. Keeping in view of the importance of this organic moiety in the field of medicine and biology here an attempt has been made to review the synthesis and biological importance of heterocyclic Mannich base derivatives.

This work represents the synthesis and characterization some new versatile intermediates namely4-amino-1,2,4-triazole-5(4H)-thionederivatives in a one-step fusion method. The method works to be superior compared to the existing method by Reed and Handel which consists of four steps. The antibacterial activity of compounds is tested against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Staphilococcusaureus. The compounds exhibited species specific activity. Among the tested compounds,1a and 1b exhibited good activity at moderately low concentration (31.25µg/mL)against tested strains of bacteria.DPPH (1,1-diphenyl-2-picryl-hydrazyl), FRAP (ferric reducing antioxidant power) and Lipid peroxidation assays are performed to determine thein vitro antioxidant activities. The compound 1e exhibited good antioxidant activity among the tested compounds.