1. Expression quantitative trait loci in sheep liver and muscle contribute to variations in meat traits
- Author
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Zehu Yuan, Bolormaa Sunduimijid, Ruidong Xiang, Ralph Behrendt, Matthew I. Knight, Brett A. Mason, Coralie M. Reich, Claire Prowse-Wilkins, Christy J. Vander Jagt, Amanda J. Chamberlain, Iona M. MacLeod, Fadi Li, Xiangpeng Yue, and Hans D. Daetwyler
- Subjects
Animal culture ,SF1-1100 ,Genetics ,QH426-470 - Abstract
Abstract Background Variants that regulate transcription, such as expression quantitative trait loci (eQTL), have shown enrichment in genome-wide association studies (GWAS) for mammalian complex traits. However, no study has reported eQTL in sheep, although it is an important agricultural species for which many GWAS of complex meat traits have been conducted. Using RNA sequence data produced from liver and muscle from 149 sheep and imputed whole-genome single nucleotide polymorphisms (SNPs), our aim was to dissect the genetic architecture of the transcriptome by associating sheep genotypes with three major molecular phenotypes including gene expression (geQTL), exon expression (eeQTL) and RNA splicing (sQTL). We also examined these three types of eQTL for their enrichment in GWAS of multi-meat traits and fatty acid profiles. Results Whereas a relatively small number of molecular phenotypes were significantly heritable (h2 > 0, P
- Published
- 2021
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