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1. [Brain protein synthesis in awake rats: equilibrium of L-methionine between plasma and direct precursor pool].

Author

Grange E, Gharib A, Lepetit P, Guillaud J, Sarda N, and Bobillier P

Subjects
Animals, Male, Methionine blood, Rats, Rats, Inbred Strains, Subcellular Fractions metabolism, Brain Chemistry, Methionine metabolism, Protein Biosynthesis, RNA, Transfer, Met metabolism
Abstract

After 1 hr. of continuous infusion of L-(35S)methionine the specific activities of L-methionine in plasma and tissue-free and tRNA-bound L-methionine in brain were in the same range. This result indicates that, under steady-state conditions, dilution of the precursor pool for protein synthesis (L-methionyl-tRNA) by L-methionine derived from a source other than plasma can be considered as negligible.

Published
1991

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