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1. [Factors regulating protein synthesis by rabbit reticulocyte ribosomes: variations in their concentrations during cell maturation].

Author

Mahendra M, Goswami ND, Kermel M, and Koche MJ

Subjects
Animals, Cell Differentiation, Cell-Free System, Chromatography, Gel, Cytoplasm metabolism, Depression, Chemical, Detergents pharmacology, Erythrocytes ultrastructure, Leucine metabolism, Male, Phenylalanine metabolism, Poly U metabolism, Potassium Chloride pharmacology, Rabbits, Reticulocytes ultrastructure, Ribosomes drug effects, Stimulation, Chemical, Erythrocytes metabolism, Protein Biosynthesis, Reticulocytes metabolism, Ribosomes metabolism
Abstract

An activator as well as an inhibitor of protein synthesis, were isolated from rabbit reticulocyte ribosomes. The ribosomes of the erythrocytes are inactive in protein synthesis and lacked the activator. However, when the activator moiety was added to the erythrocyte ribosomes, there was a significant increase in their capacity for protein synthesis, provided these ribosomes were freed of their inhibitor by washing beforehand with a detergent.

Published
1975

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