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Abstract Background The genetic mechanisms that underlie phenotypic differentiation in breeding animals have important implications in evolutionary biology and agriculture. However, the contribution of cis-regulatory variants to pig phenotypes is poorly understood. Therefore, our aim was to elucidate the molecular mechanisms by which non-coding variants cause phenotypic differences in pigs by combining evolutionary biology analyses and functional genomics. Results We obtained a high-resolution phased chromosome-scale reference genome with a contig N50 of 18.03 Mb for the Luchuan pig breed (a representative eastern breed) and profiled potential selective sweeps in eastern and western pigs by resequencing the genomes of 234 pigs. Multi-tissue transcriptome and chromatin accessibility analyses of these regions suggest that tissue-specific selection pressure is mediated by promoters and distal cis-regulatory elements. Promoter variants that are associated with increased expression of the lysozyme (LYZ) gene in the small intestine might enhance the immunity of the gastrointestinal tract and roughage tolerance in pigs. In skeletal muscle, an enhancer-modulating single-nucleotide polymorphism that is associated with up-regulation of the expression of the troponin C1, slow skeletal and cardiac type (TNNC1) gene might increase the proportion of slow muscle fibers and affect meat quality. Conclusions Our work sheds light on the molecular mechanisms by which non-coding variants shape phenotypic differences in pigs and provides valuable resources and novel perspectives to dissect the role of gene regulatory evolution in animal domestication and breeding.

The deficiency in knowledge of English phonetics constitutes a significant contributing factor to the lower proficiency observed among college students in terms of their listening and speaking skills in English. By implementing a communicative approach, an action research study was conducted with the aim of enhancing students’ pronunciation and intonation within speech flow, thereby effectively improving their ability to communicate in English. This investigation suggests that incorporating phonetic instruction into college-level English education can augment language acquisition accuracy and enhance students’ linguistic proficiency when expressing themselves, ultimately facilitating successful communication in the English language.

This article takes the construction of provincial-level high-level professional groups as the background, with the main line of promoting high-quality development of vocational colleges, deepening school enterprise cooperation, high-quality employment of students, and creating brand characteristic majors. The goal is to build a technical skills platform for vocational college professional groups. In order to promote the improvement of teaching quality in vocational colleges, achieve high-quality employment for students, and focus on high-level professional groups, construction ideas and measures have been proposed to better build a platform for technological skill innovation.

This article focuses on the teaching methods and modes of Linux operating system courses, and proposes a project driven micro course design and production method. Based on the actual work tasks of enterprises, it introduces the integration of specific cases into teaching micro course design practice from various aspects such as resource construction objectives and construction ideas. The aim is to provide reference and guidance for the construction of micro course resources in computer related professional courses, and help students improve learning efficiency.

The integrated solar thermal photovoltaic cooker utilizes slot type high-temperaturecondensing technology to heat the food inside the vacuum tube, solving the problem of food heating when going out. The photoelectric conversion and energy storage are used to reduce dependence on conventional energy, realize electric energy heating, and solve outdoor power consumption problems. This structure includes an arc-shaped parabolic condenser plate, which is located at the lower part of the vacuum tube. The upper end of the solar vacuum tube is equipped with a steamer, which is normally heated by the heat stored in the solar vacuum tube. The inclined bottom of the steamer is equipped with an electric heating wire, which provides power through a solar cell module to heat the food inside the vacuum tube.

This study aims to explore the relationship between Organizational Stressors for Sport Performers, Sports Mental Toughness and aerobics athletes’ Competitive Cognitive Trait Anxiety, and to analyze the role of virtual reality technology in the regulation of Competitive Cognitive Trait Anxiety. The study used literature methods to sort out the use of virtual reality technology in sports training, and tested the mental status of 91 aerobics athletes through questionnaires. The results found that there is a significant correlation between aerobics athletes’ Competitive Cognitive Trait Anxiety, Organizational Stressors for Sports Performers and Sports Mental Toughness; virtual reality technology can reduce aerobics athletes’ Competitive Cognitive Trait Anxiety. According to the research results, virtual reality technology can be used to simulate training and competition scenarios to reduce Competitive Cognitive Trait Anxiety, thereby effectively improving aerobics athletes’ performance levels.

Hydrogen internal combustion engines (H2-ICEs) have advantages such as clean combustion and zero carbon emissions, and have become one of the important technical routes for decarbonization in the internal combustion engine industry. In this paper, several key factors affecting the performance and emissions of hydrogen internal combustion engines, such as ignition timing, excess air coefficient, and hydrogen injection timing, were systematically studied on a spark ignition multi-point injection (MPI) hydrogen internal combustion engine bench. The experimental results indicate that the ignition timing controls the combustion phase of hydrogen. Moderate early ignition can improve the brake thermal efficiency (BTE) while having little impact on the NOX emissions. Excess air coefficient(λ) can significantly affect the performance and emissions of H2-ICE. Along with the increase of the λ, the NOX emissions first increases and then continues to decline. When the λ reaching 2.1 or above, near zero emissions of NOX can be achieved. The advance of hydrogen injection timing will slightly increase the peak of cylinder pressure and instantaneous heat release rate. However, overall, the impact of hydrogen injection timing on BTE and NOX emissions is not significant on MPI H2-ICE.

The purpose of this study is to design and simulate a PV water pumping system at Sam Ratulangi University in Indonesia. The methods employed in this study consist of a literature review, design, and simulation using HOMER (Hybrid Optimization of Multiple Energy Resources) software. The comparison between PV water pumps and dieselpowered water pumps is analysed in terms of net present cost, cost of energy (COE), and emissions to meet the water requirements in the laboratory. The simulation results are based on two design scenarios for a solar photovoltaic water pumping system at a laboratory scale. In Scenario 1, the system has a daily load of 1.5 kWh/day, 0.52 kW PV modules, 4 batteries of 80 Ah each, and a 1 kW inverter. In Scenario 2, the system has a daily pump load of 2.5 kWh/day, 0.87 kW PV modules, 4 batteries of 80 Ah each, and a 1 kW inverter. The results indicate that the utilization of solar energy to power a PV water pumping system performs well and serves as a case study showcasing the use of solar energy. Further studies on the application of PV water pump should be implemented and tested to evaluate the system’s performance.

The advent of electric aircraft heralds a transformative era in aviation, offering a sustainable alternative to conventional aircraft that significantly contribute to carbon emissions. This paper discusses the application of advanced materials in overcoming the technical hurdles associated with electric propulsion systems, focusing on their application in airframe construction, electrical conductors, thermal management, and battery technology to enhance the performance and sustainability of electric aircraft. Advanced composites like carbon fiber reinforced polymer (CFRP) are explored for their potential to reduce aircraft weight and improve mechanical properties. The paper also addresses the challenges of thermal management in electric propulsion systems, highlighting the use of phase change materials (PCMs) and advanced ceramics for efficient heat dissipation. Furthermore, the exploration of high-energy-density cathode materials, innovative anode materials, and solid-state electrolytes is discussed in the context of developing lightweight, high-capacity batteries for electric aircraft. Despite the promising advancements in material science and the potential benefits of electric aviation, the paper acknowledges the existing challenges, including the high cost of advanced materials, the need for improved energy storage solutions, and the environmental impact of material production.

But de l’étude : Le projet consistait à concevoir, perfectionner et tester une approche de dépistage de la détresse auprès des survivants du cancer qui fréquentent des organismes communautaires de soutien aux personnes atteintes du cancer.Méthodologie : Le projet s’est décliné en plusieurs phases; on a notamment effectué une revue de la littérature récente et formé des groupes de discussion avec les survivants du cancer et le personnel d’organismes communautaires. Les données ont été collectées pour servir d’assise à la conception et à la mise en œuvre d’une nouvelle approche de dépistage adaptée aux organismes communautaires de soutien du cancer qui souhaitent identifier la détresse psychosociale de leurs membres.Résultats : Les questionnaires normalisés utilisés dans les approches de dépistage de la détresse en contexte clinique n’étaient pas considérés comme appropriés par les survivants du cancer qui cherchaient du soutien en milieu communautaire. Une nouvelle approche de dépistage a été conçue et mise en œuvre en tenant compte des commentaires des survivants du cancer et du personnel des organismes communautaires. L’outil utilisé dans l’approche de dépistage était axé autour des problèmes pertinents des personnes en milieu communautaire. Si des problèmes étaient identifiés, le personnel suivait une trajectoire de soins personnalisée pour les résoudre. Les patients comme les employés ont trouvé l’approche de dépistage utile pour repérer les problèmes et les solutions afférentes.Conclusions : Les approches de dépistage de la détresse peuvent être utiles dans un contexte de soutien communautaire aux survivants du cancer pour identifier les personnes très à risque de vivre des difficultés. Les données du dépistage peuvent servir aux organismes qui souhaitent faire état de l’efficacité de leurs services.

Purpose: This project was designed to develop, refine and field-test a distress screening approach with survivors accessing community-based cancer support agencies.Methods: The project was conducted in phases including a literature review and focus groups with cancer survivors and community agency staff. Data were gathered to lay the foundation for building a subsequent development and implementation of a new screening approach suitable for community-based cancer support agencies to use in identifying psychosocial distress in their clients.Results: Standardized questionnaires used for distress screening approaches in clinical settings were not seen by cancer survivors as appropriate for community-based cancer support settings. A new screening approach was designed and implemented based on input from cancer survivors and staff in community-based agencies. The tool used in the distress screening approach focused on problems relevant to individuals in the community setting. If problems were identified, staff followed tailored care pathways to resolve them. Both patients and staff found the screening approach useful for quickly pinpointing problems and avenues for dealing with the issues.Conclusions: Screening for distress approaches can be useful in a community-based cancer support setting to identify individuals who are at greater risk for experiencing difficulties. Data from screening can be useful for agencies to report on their service effectiveness.

College education is an important stage for students to carry out their own development and progress. Therefore, in the college education stage, it is a very important thing for the construction of teachers in higher vocational colleges. Only when the professional ethics of teachers can be better guaranteed, can college students get better development and progress. Through the query of literature, and based on this put forward certain construction plan, make our university education construction can make better construction and progress, hope to promote our university education construction to produce a certain practical significance and promote the process of moral construction. This paper makes a specific analysis of the problems of teachers in the field of intelligent construction in the overseas running of higher vocational colleges, hoping to put forward some suggestions on the problems of teachers in the field of intelligent construction in the overseas running of higher vocational colleges, and make reasonable planning for the problems of teachers in the overall running of higher vocational colleges combined with some practical knowledge related to human resource management. Make the overall can get better construction and development, promote the construction of higher vocational colleges overseas teachers.

Under the background of implementing the strategy of healthy China and rural revitalization in the new era, the education and management of free oriented medical students in rural areas has been paid more and more attention. The employment guidance courses for free orientation students in rural areas are becoming more and more standardized, and the class schedule has been developed from scratch, but the course design, especially the interaction between teachers and students during online teaching, is not sufficient. The conclusion of the study is that the free orientation medical students’ employment guidance courses in rural areas should strengthen the ideal and belief education modules, tailor-made career planning, and use experiential teaching methods to train students to grow up to be good at treating minor diseases, being good at treating serious diseases, being good at managing chronic diseases, Qualified grassroots general practitioners who turn from acute illness to improvement.

5-Nitraminotetrazole (5-NAT) is a high-energy and green explosive material that has attracted extensive attention due to its short synthesis steps and decomposition products consisting mainly of nitrogen and water. However, the presence of a crystal water molecule in the current crystal structure of 5-nitroaminotetrazole significantly affects its detonation performance and mechanical sensitivity. In this study, we report the successful synthesis of an anhydrous crystal form of 5-NAT through slow volatilization of an ethyl acetate solution under dry conditions. The anhydrous crystal form of 5-NAT exhibited increased density and detonation velocity compared to the monohydrate crystal form. Furthermore, quantum chemical analysis showed that the anhydrous crystal form exhibited increased sensitivity to external force stimulation due to stronger oxygen-oxygen and nitrogen-oxygen repulsion. In conclusion, the anhydrous crystal form of 5-NAT shows promise as a high-energy and green primary explosive.

Combine the requirements of new engineering construction and required by China 2025 for professional personnel training, and meet the industry's demand for high-quality technical personnel. This paper takes the mechanical major as an example, puts forward the construction of characteristic specialty for the construction of new engineering course. Reforming the original talent training mode, strengthening the training of engineering application ability and innovative practice ability, and building a characteristic professional teaching and practice system that meets the needs of enterprises and serves local industries. Throughout the project teaching method and the whole teaching process, which is based on engineering practice education center, furthermore, it deepen cooperation between colleges and enterprises, production and education integration, which establishing an all-round quality guarantee and monitoring system. And it cultivates application-oriented engineering practice and innovation ability of the foundation.

With the rapid development of urban economy, the value of China's light resources has been explored, but its impact on ecological environment has also been gradually intensified. In order to establish a universal light pollution measurement standard model, this paper uses the combination of AHP and EWM to determine the index weight, and gives the calculation method and index evaluation standard of theoretical data. In order to measure the risk level of light pollution numerically, this paper uses the PEST analysis model to construct the light Pollution Risk Index (LPI ) and establish the index group. The Fuzzy Delphi Method is utilized to screen the first-level indicators and the second-level indicators, and finally 4 first-level indicators and 14 second-level indicators are obtained. Using this evaluation model, the degree of light pollution in different areas was evaluated by questionnaires, and the results showed that urban areas had the most serious light pollution. Finally, based on the night sky brightness formula, this paper analyzed the sensitivity of the algorithm. The results showed that the selected quantitative indicators have strong stability and the model has strong robustness.

In recent years, With the rapid development of the computer industry, The requirements for computer talents are also increasing. At present, some universities’ talent cultivation models cannot meet the development requirements of the computer industry. In response to this situation, this article proposes a school enterprise collaborative education model based on Huawei standards, guided by market demand and starting from school enterprise collaborative education, aiming to improve the quality of talent cultivation from multiple aspects such as professional construction, school enterprise cooperation, and course assessment methods.

With the deepening of the construction of the Guangdong-Hong Kong-Macao Greater Bay Area and the vigorous development of the digital economy in the region, the digital economy will become a distinctive feature of the Greater Bay Area. With the continuous advancement of industrial transformation and upgrading and digital economic construction, the demand gap for high-quality technical and skilled talents in the construction of regional economy will also become larger and larger. In the process of building a provincial-level high-level Major Group of computer application technology, our school actively explores and studies the characteristics of the new generation of information technology and digital economy-related talent training, and carries out in-depth school-enterprise cooperation. Both schools and enterprises jointly carry out teaching method reform and teacher training. , Textbook construction. The aim is to improve the professional ability of students in Major Group in multiple aspects, cultivate more talents in the digital economy that meet the needs of enterprises and society, improve the ability to serve regional economic development, and achieve the purpose of high-quality employment in schools.

This paper examines the effect of tax cuts policy on firm survival risk. We analyze a panel data of China’s listed companies over the period 20082021 based on two different techniques: Kaplan-Meier survival estimator and the Cox proportional hazards model. Our findings reveal that the tax cuts policy has positive and significant effect on improving firms’ survival probabilities. Moreover, compared with the income tax cuts, the value-added tax cuts play a more effective role on improving firms’ survival probability. By dividing firm locations into different regions, we also find that the tax cuts policy exerts a positive influence on firms’ survival probabilities in eastern region, while the positive effect in the central and western regions is relatively weaker. From the perspective of profitability heterogeneity, the results show that the beneficial effect from tax cuts policy on firm survival is more pronounced for firms with weaker profitability.

Taking the computer application technology professional group of Guangdong Innovation Technology College as an example, we study the problems of computer professional group in the construction of curriculum thinking politics, firstly, we explore the basic requirements of curriculum thinking politics from the perspective of “ Three-Whole Education “, then we explore the value of curriculum thinking politics, and then we study the top design and bottom implementation of talent training of professional group from many aspects. Then, we will explore the value of curriculum thinking and politics, and then carry out research from various aspects such as top-level design and bottom-level implementation of professional group talent training. We will build the construction pattern of “Three-Whole Education”, and combine with the construction of professional groups to build the construction pattern of the curriculum of professional groups in terms of talent training objectives, thinking and political objectives, thinking and political content, etc., so as to promote the construction of the curriculum of the provincial-level professional group of computer application technology in our university and realize the educational goal of cultivating people with moral character.

With the deepening of the construction of the Guangdong Hong Kong Macao Greater Bay Area, the goal of building a high-level professional group in vocational colleges is to optimize the professional structure to meet industrial demands, take industrial demands as the fundamental basis for forming professional groups, and cultivate high-quality technical and skilled talents. Our school closely focuses on the construction and development plan of the Greater Bay Area, builds a high-level computer professional group, and strives to promote the integration of industry and education. In order to improve the quality of teaching and promote the high-quality development of talent cultivation in vocational colleges, we have proposed construction ideas and measures.

To help the transportation sector achieve the goal of the energy saving and low-carbon transformation, including highway, waterborne, urban transportation and ports. This paper sets four development scenarios to predict the carbon emission of the transportation sector in Guizhou province. Results indicate that in business-as-usual scenario, the carbon emissions show an overall upward trend; in high speed development scenario, the transportation in Guizhou province will reach a carbon peak in 2030, with a peak value of 8.76 million tons. China should actively take measures for energy saving and carbon reduction. By 2060, optimization of the energy structure contributes more carbon reduction than the optimization of transportation structure. We will promote the energy-saving and green development of China’s transportation carbon emissions.

Flash drought is a type of drought that develops rapidly, lasting for a short period of time, and is highly destructive. During its rapid intensification stage, it is usually accompanied by high temperature, high evapotranspiration, soil moisture decline, and precipitation deficit, thus causing significant damage to ecosystems and human society. Many attempts have been made to distinguish the phenomenon of flash drought from drought and to better understand the mechanisms of its generation. Since 2013, researchers have continued to refine and clarify the definition of flash drought in response to its characteristics, and have made many efforts to propose appropriate identification methods, classify the phenomenon of flash drought, identify the mechanism of flash drought generation, and improve the early warning capability of flash drought disasters. Despite this, researchers still do not have a clear and consistent system for identifying and classifying flash drought emergencies. In addition, some researchers have explored the spatial dynamics of flash drought propagation, hoping to better understand the spatial and temporal characteristics of flash drought.

With the deepening of industrial transformation and upgrading and reform of vocational education, the demand of society for high-level vocational technicians has increased. Combining with the “20 articles of vocational education” and “1+X” certificate system pilot project, based on the existing system of secondary and higher vocational education in our college, we jointly carry out the reform of “integration of courses and certificates” with Guangdong University Of Science & Technology. According to the characteristics of the school’s majors, the vocational skill level certificate of “intelligent computing platform application development” was selected as a pilot reform, and the X certificate was fully utilized as the basic measure and standard for practitioners to measure their competence, so as to build an integrated talent training system of middle and high school, and to realize the organic connection between the curriculum systems of middle school, high school and undergraduate levels. This will help cultivate more excellent technical skills talents for the Guangdong-Hong Kong-Macao Greater Bay Area and is expected to provide a reference for building a perfect vocational education system.

This study aims to explore the impact of consumers’ perception of green and sustainable development goals (SDGs) image in fashion brands on their value perception and the attractiveness of product design. Fashion brands do not only strive for fashion, innovation, avant-garde, comfort, quality, and reasonable prices, but also placing increasing emphasis on sustainability, environmental friendliness, and social responsibility. As SDGs have become a shared vision and value perception among consumers, clothing with SDGs attributes is becoming fundamental for blue ocean strategies and competitive differentiation. Using the example of fashion brand SDGs image design, this study applies the “two-way questionnaire” method of the Kano quality model to investigate the correlation between quality evaluation of product cultural and ecological attributes and consumer satisfaction. Through the two-dimensional quality of the Kano model, consumers’ attitudes towards clothing with SDGs attributes are clarified more accurately. This study provides specific improvement plans to enhance the quality of green and sustainable fashion with SDGs attributes and emphasizes the incorporation of SDGs into the decision-making of fashion brands, which will have a significant impact on brand image.

The article reports on a series of initiatives by the Swiss Ornithological Station, including the implementation of a project named "A New Dawn for Birds," which has successfully transformed a large land into high-quality habitats for threatened bird species. It discusses the role of technology, such as GPS transmitters, in monitoring bird migrations and improving ecological knowledge.

In this study, fifteen participants were exposed in an enclosed environmental chamber to investigate the effects of elevated carbon dioxide (CO2) concentration on their cognitive abilities. Three CO2 conditions (1500 ppm, 3500 ppm, and 5000 ppm) were achieved by constant air supply and additional ultra-pure CO2. All participants received the same exposure under each condition, during which they performed six cognitive tests evaluating human perception, attention, short-term working memory, risky decision making, and executive ability. During each exposure condition, the reaction time (RT) test, speed perception test, visual search (VS), 2-back test, balloon analogue risk test (BART), and Stroop test were successively conducted with rest intervals of approximately 13min. The results showed that there was no statistically-significant difference in the performance of RT tests, speed perception test, and 2-back test. This indicated that the elevated CO2 concentration below 5000 ppm did not affect the participants’ perception and short-term working memory. However, significant increase of response time was observed in the VS test, BART, and Stroop test at 5000 ppm compared with lower exposure concentrations. The slower reaction reflected the negative effects of elevated CO2 concentration on human visual attention, risky decision making, and executive ability. The findings suggest that work performance could be negatively affected by the exposure to CO2 at the current occupational concentration limit.

Development of local climate is important for climate hazard assessment. Cameron Highlands was chosen as study area (longitude from 101°21’ to 101°30’ and latitude from 4°19’ to 4°37’) for climate downscaling. This paper presents the work of downscaling techniques and regional climate model (RCM) development. The second-generation Canadian Earth System Model (CanESM2) based on the representative concentration pathways (RCP) 4.5 and 8.5 was applied to develop the local climate model for the period 2020-2100. The climatic parameters chosen were temperature (maximum and minimum) and rainfall. The simulated RCMs are then analysed using statistical reliability including Pearson correlation coefficient, linear regression, root mean square error (RMSE) and probability density function (PDF). The result showed that the simulated maximum, minimum temperature, and rainfall are most likely to follow RCP 8.5 scenario. Precipitation threshold for occurrence of flood event was estimated using intensity duration frequency (IDF) relationship generated by maximum precipitation. Return period of two years and four hours rainfall duration is used for threshold estimation as the rainfall is convective. The daily rainfall threshold for flood occurrence is estimated to be 11.3 mm/hr.

In the view of new media, when Hainan higher vocational colleges carry out the education of network ideology, they should actively hold high the banner of the main melody, carry out in-depth the great action of Hainan civilization, and strengthen the mainstream ideological public opinion by consolidating, we should carry forward the main theme, dare to respond to the wrong trend of thought and the public opinion that confuses right and wrong, study the changes of the public opinion on the Internet, improve the control ability of the public opinion, seize the new highland of the propaganda thought, and improve the quality of the education of the network ideology in an all-round way. Based on the new media field of vision, this paper makes a systematic study on the network ideology education in Hainan higher vocational colleges.

At present, there are still some problems existing in college students’ innovation and entrepreneurship, such as lack of funds, lack of entrepreneurial values, and poor social skills. This paper analyzes the current situation and existing problems of innovation and entrepreneurship education as well as the optimizing strategies. It is concluded that, in China, the existing problems of contemporary college students’ innovation and entrepreneurship include the shortage of funds, the lack of practical experience, and the weak innovation and entrepreneurship abilities, Then, the author proposes some strategies to solve these problems accordingly. First is to optimize the curriculum by combining the theoretical study with practice. Second, the policies related to entrepreneurship need to be adjusted and the cooperation with enterprises should be strengthened. It is also essential to vigorously develop the entrepreneurial projects with good market potential, and encourage and support college students to conduct micro-entrepreneurship from all aspects. Third, there is a need to enhance the partnership with the company, thus providing a better way for college students to build a culture of innovation and entrepreneurship. Last but not least, a micro-platform should be established for college students’ entrepreneurship and more superior resources should be given to them for innovation and entrepreneurship.

Equality and law have always been an important proposition of human concern, which embodies the relationship between human beings and is an important guarantee of social harmony and stability. Rousseau, as an 18th century French Enlightenment thinker and an important representative of the doctrine of natural law and social contract theory, constructed the hypothesis of the state of nature and systematically put forward the concept of social equality and the concept of public will law, which together with Hobbes, Locke and other scholars’ theories. They have profoundly influenced the formulation of laws and the construction of administrative systems in Western countries. The study of this work will help to understand the underlying logic of Western institutional settings and clarify the purpose of equality and law. This article uses both documentary research and comparative analysis to review Rousseau’s views on equality and law and to return to primary sources. The study also compares and contrasts Rousseau’s views with those of Hobbes, such as the state of nature and the state.

Interest in measuring patient-reported outcomes has been growing within cancer care facilities. In particular, community-based agencies want to identify appropriate patient-reported outcomes to use in evaluating their programs. Willow Breast Cancer Support Canada undertook a series of interviews with staff, peer volunteers and clients to identify the most relevant patient-reported outcomes for their telephone peer support service. Both process and outcome variables were identified as relevant for future measurement. The approach utilized and the outcomes identified could serve as a model for similar organizations to implement.

La mesure des résultats rapportés par les patients suscite un intérêt croissant dans les centres de cancérologie. Les organismes communautaires cherchent notamment à relever les résultats rapportés par les patients appropriés en vue de les intégrer dans l’évaluation de leurs programmes. L’organisme canadien Willow Soutien pour le cancer du sein ou héréditaire a ainsi mené une série d’entrevues auprès de son personnel, de pairs bénévoles et de clients pour faire ressortir les résultats rapportés par les patients les plus pertinents concernant son service de soutien téléphonique offert par des pairs. Des variables relatives tant aux processus et qu’aux résultats ont ainsi pu être cernées en vue d’être mesurées ultérieurement. L’approche retenue et les résultats mis en lumière pourraient servir de modèle à des organisations similaires.

Background: The association between short-term changes in serum magnesium level and risk of in-hospital mortality was investigated in patients with acute myocardial infarction (AMI). Methods: In this retrospective cohort study, data of 2,716 patients with AMI were extracted from the Medical Information Mart for Intensive Care (MIMIC-III and MIMIC-IV) database for 2001-2012. Univariate and multivariate Cox proportional hazards models were used to explore the association between serum magnesium level and short-term change and in-hospital mortality in patients with AMI. In addition, subgroups according to age, gender, Sequential Organ Failure Assessment (SOFA) score, and Simplified Acute Physiology Score (SAPS-II) were also analysed. Results: In total, 504 (18.6%) patients died in hospital. After adjusting for covariates, all AMI patients with high magnesium levels at ICU admission (HR=1.03, 95% CI: 0.83-1.27) or 48 hours after ICU admission (all p <0.05), or those demonstrating a change in magnesium level within the first 48 hours of ICU stay (all p <0.05) were shown to have a high risk of in-hospital mortality. Moreover, this correlation was retained irrespective of age, gender, SOFA score, and SAPS-II (all p <0.05). Conclusion: Serum magnesium levels at different time points after ICU admission and change in serum magnesium level during the first 48 hours were associated with in-hospital mortality in patients with AMI, indicating that clinical attention should be paid to short-term changes in serum magnesium levels regarding treatment adjustment, which may further reduce the risk of mortality. [ABSTRACT FROM AUTHOR]

In finance area, portfolio construction is one of the most vital questions since the primary work of modern finance and attract numerous studies. In this paper, we focused on this issue in pharmaceutical industry since the industry is crucial for human beings. We adopted several methods for portfolio construction, like Equal Weighted Model, Monte Carlo simulation, and maximize Sharpe ratio etc. Specifically, five assets are selected. Then based on the Monte Carlo method, we constructed two optimized portfolios in the framework of the efficient frontier, i.e., portfolios with minimum variance and maximum Sharpe ratio. By analyzing the two portfolios, we found that the NVS accounts for the largest proportions in the optimized portfolio. The results in this paper may shed lights for certain investors who invest in pharmaceutical industry.

In recent years, the discussion of artificial intelligence has become a trend. With artificial intelligence gradually replacing more human work, artificial intelligence plays the role of “semi rational man” in the era of big data. One of the key issues in the academic discussion is the ethical issues of artificial intelligence intervention in the work of rational social people, such as: Does the leadership of artificial intelligence intervention violate the ethical standards of most people? This paper takes the artificial intelligence intervention in the construction of virtual leadership as the thinking object, and puts forward some thoughts on the ethical principles of artificial intelligence.

Autism spectrum disorder (ASD) is a series of neurodevelopmental disorders presented as behavioral abnormality such as problems with social, communication, and repetitive behaviors. There are four ASD-related monogenetic diseases worthy of analysis: fragile X syndrome, PTEN hamartoma tumor syndrome, tuberous sclerosis complex, and Rett syndrome. These four monogenetic diseases are respectively caused by one gene and have something in common in phenotype while also have their unique features. All of them have been related to the same pathway: phosphatidylinositol 3-phosphate kinase (PI3K) / protein kinase B (PKB or Akt) / mammalian target of rapamycin (mTOR) signaling pathway, which plays a primary role in many physiological processes on a cellular level. Nowadays, there is no cure for these monogenetic diseases, thus much remains to be done to find ways to treat patients with the diseases mentioned above.

Innovation and technological progress are essential approaches to sustainable growth, but what will affect enterprises’ innovating motivation hasn’t been thoroughly analyzed. We establish an endogenous growth model to analyze the factors that influence an enterprise’s innovation investment, and find that the cumulative technology plays a key role: the more cumulative technology an enterprise has, the more its R&D investment will be. Empirical researches confirm the theoretical conclusions. Our study provides suggestions for policies to promote technological progress and sustainable development.

A geared rotor system model consisting of UPE gears and steel gears for medium speed, medium load and long servo time is proposed. The solid models of steel-steel, steel-UPE and UPE-UPE gear systems were established. The dynamic models of steel-UPE gear system and UPE-UPE gear system were reconstructed by using the theoretical mechanical model of UPE. The time-varying meshing stiffness of three gear systems is analyzed. The vibration responses of three gear systems are studied by STFT method. The dynamic loads of three gear systems under different loads and rotational speeds are researched in detail, and the changing rules of dynamic loads of three gear systems under different loads and rotational speeds are revealed. At last, the first ten modes of three gear systems are calculated and the results are discussed. At the same time, the modal results are used to verify the correctness of the research on vibration response and dynamic load of three gear systems.

This paper discusses the safety protection design of lithium iron phosphate batteries based on the technical characteristics of lithium iron phosphate batteries. Combined with the current background of the application of lithium iron phosphate batteries in substations, the system design of lithium iron phosphate batteries is discussed from many aspects. It focuses on how to ensure its safety in order to improve the application effect of lithium iron phosphate batteries in substations.

This study makes use of soybean oil to produce biodiesel using SO42-/ZrO2-HJ-2# caly solid acid catalyst (SZ-HJ-2#). It was through coprecipitation and impregnation method that the catalyst was prepared which was then characterized by means of FE-SEM, XRD, EDS, BET, FT-IR, ICP-MS, NH3-TPD and XPS. The catalytic property of the synthesized catalyst was determined by using it to produce biodiesel from soybean oil. A study was carried out to find the effect of the different preparation condition of catalyst affecting the process. For SZ-HJ-2#, Optimized condition of 0.5 mol/L(zirconium salt solution), 1.5 mol/L (the concentration of sulfuric acid impregnating solution) and 450℃(calcination temperature). Optimized conditions of 8.32:1 methanol to soybean oil molar ratio and catalytic loading of 1 wt% at 55℃ with a stirring rate of 500 rpm for a reaction duration of 10 h gave a maximum yield of 89.6 wt%. Moreover, the further investigation indicated the catalytic activities were closely related to the ratio of Brönsted acid sites and intensity on catalysts. Besides, the excellent performance of the catalyst during recycling was shown by conducting reusability study.

In this paper, a kind of implantble passive wireless surface acoustic wave (SAW) sensor and its reader are developed to measure the operation temperature of high voltage crossed-linked cable core. A small type SAW temperature sensor is embedded into cable intermediate joint. A radio frequecny transceiver of the reader based on discrete devices is optimally designed to achieve high signal-to-noise ratio and receiving sensitivity. The characteristic of resonant frequency and temperature of SAW sensor is determined by frequency scan method. Through AC withstand voltage and temperature rise test of 110kV cable, it proves that the prototype can accurately measure the operation temperature of 110kV cable core in intermediate joint under high operation temperature and strong electromagnetic environment.

Based on the actual background of a pumped storage company, this paper researches and builds the supplier holographic multidimensional evaluation system. By building supplier data mart, it realizes supplier data integration and visual management. By building supplier portrait system, it reflects the comprehensive performance of suppliers in different business scenarios. By applying the supplier multidimensional holographic evaluation system, from the life long perspective of supplier management, this paper realizes intelligent comparison of qualification performance verification data, bidding assistant management, real-time control of performance process, supplier recooperation assistant decision and so on, so as to assure the company’s safe and stable operation.

Space syntax has injected new vitality into quantitative and parameterized planning and design of middle school campus. Although, there are extensive interpretative problems in space syntax that need to be clarified during engineering planning and design of campus. This paper focuses on: (1) the parameters and models of space syntax are clarified from the perspectives of planning and design; (2) the specific application of space syntax in campus planning and design is discussed from the four stages of preliminary research, scheme analysis, scheme design and scheme optimization; (3) a relatively reliable quantitative, visual and procedural post-evaluation system of campus planning and design is provided with GIS spatial analysis technology and dynamic simulation means.