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The essay reflects on the context of the publication and reception of The Portuguese Empire in Asia, 1500-1700, a book that first appeared in 1993, and was translated into Portuguese, French and Chinese. It suggests that while some of the principal arguments of the book have gained acceptance, others have been resisted in many quarters. Notably, the book’s plea to insert Portuguese activities in their full Asian and East African historical and historiographical contexts has only been espoused by a minority of historians.

Currently, one of the most common causes of skin biopsy in non-tumor pathology are skin reactions to drugs. These can manifest virtually as all known histopathological patterns. Adverse drug reaction (ADR) is defined by WHO as a response to a drug which is noxious and unexpected, which occurs at doses normally used in humans for prophylaxis, diagnosis, therapy of a disease or for modification of physiological function. We describe here the most frequent interface drug induced dermatitis and present three clinical cases.

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