1. [Lipid peroxidation and free radicals. Role in cellular biology and pathology].
- Author
-
Clavel JP, Emerit J, and Thuillier A
- Subjects
- Animals, Antineoplastic Agents adverse effects, Antioxidants, Catalase metabolism, Cell Membrane metabolism, Chemical and Drug Induced Liver Injury metabolism, Glutathione Peroxidase metabolism, Humans, Hydrogen Peroxide metabolism, Hydroxides metabolism, Hydroxyl Radical, Inflammation metabolism, Inflammation physiopathology, Liver metabolism, Microcirculation, Neoplasms etiology, Oxidation-Reduction radiation effects, Oxygen metabolism, Peroxides metabolism, Superoxide Dismutase metabolism, Superoxides metabolism, Vitamin A physiology, Vitamin E physiology, Free Radicals radiation effects, Lipid Peroxides biosynthesis
- Abstract
Membrane phospholipids attack by oxygen free radicals, i.e. lipidoperoxidation, occurs in normal cellular life. This free radicals attack is controlled by a protective system, both enzymatic (superoxide dismutase, catalase, glutahione peroxidase) and non enzymatic (vitamine E). Imbalance between attack and defense can explain many pathological events. In these events, the oxidation products of unsaturated fatty acids are of fundamental importance, in particular those derived from arachidonic acid (prostaglandins, prostacyclins, thromboxanes and leukotrienes).
- Published
- 1985