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Your search keyword '"Oubelkacem, N."' showing total 46 results
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46 results on '"Oubelkacem, N."'

1. Hématopoïèse extramédullaire de localisation spinale révélant une β-thalassémie majeure.

Author

Khoussar, I., Oubelkacem, N., Abbassi, M., Kettani, O., Bouguenouch, L., Alami, N., Ouazzani, M., Khammar, Z., and Berrady, R.

Subjects
*HEMATOPOIESIS, *PNEUMOMEDIASTINUM, *MOLECULAR biology, *ELECTROPHORESIS, *ERYTHROCYTES
Abstract

Extra-medullary hematopoiesis is a rare condition that corresponds to the ectopic development of hematopoietic tissue outside the bone marrow in response to bone marrow hyperstimulation. This phenomenon occurs mainly in embryonic hematopoiesis sites (spleen, liver, lymph nodes), sometimes in other organs such as the kidneys and lungs. Mediastinal localization is more rare. We present the observation of a patient in whom the diagnosis of beta-thalassemia was evoked in front of paravertebral tissue masses related to extra-medullary hematopoiesis. Observation: A 36-year-old patient hospitalized in our NYHA dyspnea department for the last three weeks, a thoracic CT scan was performed showing the presence on both sides of the dorsal spine of the 02 spontaneously dense masses enhanced after contrast. Biologically, the blood smear showed 78% erythroblastemia of Howell-Jolly’s acidophilic erythroblasts and the presence of red blood cell anisopoikylocytosis with target red blood cells and sickle cell disease. Electrophoresis of hemoglobin showed a hemoglobin F level at 90 %, we completed with molecular biology, this result is in favor of a β0 thalassemia (β0/β0 allele). Conclusion: Our observation describes an exceptional case of spinal extra-medullary hematopoiesis whose diagnosis of B-thallasemia was made on molecular biology. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Maladies auto-immunes et sclérodermie systémique

Author

Lerhrib, L., Bouchnafati, S., Chekkori, Y., Rhandour, W., Meliani, K., Saoudi, S., Felk, R., Bouzayd, M., Oudghiri, A., Al Sadik, N., Abarkan, L., Masrour, H., Hanini, R., Oubelkacem, N., Alami Drideb, N., Ouazzani, M., Khammar, Z., and Berrady, R.

Published
2023
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10. Hypertonie oculaire et uvéite : à propos de 52 cas

Author

Masrour, H., Bouchnafati, S., Hanini, R., Rhandour, W., Felk, R., Meliani, K., Oudghiri, A., Bouzayd, M., Al Sadiq, N., Abarkan, L., Lerhrib, L., Chekkori, Y., Oubelkacem, N., Alami Drideb, N., Ouazzani, M., Khammar, Z., Berrady, R., and Saoudi, S.

Published
2023
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45. [Nasal NK/T-cell lymphoma: about two rare cases].

Author

Bouayad N, Oubelkacem N, Bono W, Masbah O, Bouhafa T, Elmazghi A, and Khalid H

Subjects
Biopsy, Combined Modality Therapy, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Etoposide administration & dosage, Humans, Lymphoma, Extranodal NK-T-Cell pathology, Lymphoma, Extranodal NK-T-Cell therapy, Male, Middle Aged, Nasal Obstruction etiology, Neoplasm Staging, Nose Neoplasms pathology, Nose Neoplasms therapy, Prednisolone administration & dosage, Prognosis, Vincristine administration & dosage, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Lymphoma, Extranodal NK-T-Cell diagnosis, Nose Neoplasms diagnosis
Abstract

NK/T-cell lymphoma is a severe and rare disorder in Africa and in Europe. Treatment is based on radiotherapy and chemotherapy. We here report two cases of elderly patients aged 55 years and 52 years, respectively, with bilateral nasal obstruction associated with purulent rhinorrhea. Clinical examination showed cleft palate. Diagnosis was made on the basis of immunohistochemical examination of biopsies. Both patients underwent CHOEP chemotherapy followed by radiotherapy. Nasal NK/T-cell lymphoma is an aggressive type of non-Hodgkin's lymphoma with specific clinicopathologic features. Combining chemotherapy with radiotherapy in patients with advanced stage of the disease does not seem to improve survival compared with radiotherapy alone, which is the treatment of choice especially for localized stages. Nasal NK/T-cell lymphoma is rare. Diagnosis is based on immunohistochemical examination. Treatment includes chemotherapy and radiotherapy. This lymphoma has a poor overall prognosis, even with appropriate therapy.

Published
2018
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46. [Digital ischemia revealing multiple myeloma].

Author

Khammar Z, Ouazzani M, Bennani B, Oubelkacem N, and Berrady R

Subjects
Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bortezomib administration & dosage, Cryoglobulinemia etiology, Dexamethasone administration & dosage, Humans, Male, Multiple Myeloma complications, Multiple Myeloma drug therapy, Necrosis, Osteolysis diagnostic imaging, Osteolysis etiology, Thalidomide administration & dosage, Fingers blood supply, Ischemia etiology, Multiple Myeloma diagnosis, Paraneoplastic Syndromes etiology, Skin Ulcer etiology, Toes blood supply
Abstract

Digital ulcers generally arise in a context of microangiopathy-related focal ischemia. In women, connective tissue diseases are the main etiology, while in men the cause is often diffuse arterial disease, e.g. Leo-Buerger disease, or emboligenic heart disease. A paraneoplastic origin of digital necrosis due to ischemia is rarely reported. A 75-year-old man presented with cyanosis of the fingertips and toes that had begun one month earlier. The physical examination found pulp ulcers on the fingers and toes of both hands and feet. Two weeks later, necrotic damage developed distally, with no other associated symptoms. Blood tests were suggestive of Kahler disease; immunodeficiency disorders tests were negative; the cyroglobulin test was positive. Multiple-drug chemotherapy was followed by clinical improvement. Distal necrotic damage is a frequent inaugural symptom in vascular disease. If the common causal mechanisms (iatrogenic, occupational, toxic, atheromatous, emboligenic heart disease, or systemic disease) have been ruled out, it is important to search for a blood disorder or cancer as the cause of distal necrotic damage., (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)

Published
2018
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