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1 results on '"Osteosarcoma ultrastructure"'

1. [Isolation and characterization of retroviruses expressed in murine osteosarcomas induced by 90Sr].

Author

Merregaert J, Michiels L, Pedersen FS, de Saint-Georges L, Janowski M, and Maisin JR

Subjects
Animals, Animals, Newborn, Mice, Mice, Inbred Strains, Microscopy, Electron, Oncogenes, Osteosarcoma ultrastructure, Sarcoma Viruses, Murine genetics, Strontium, Cell Transformation, Neoplastic, Neoplasms, Radiation-Induced microbiology, Osteosarcoma microbiology, Sarcoma Viruses, Murine isolation & purification
Abstract

The induction of osteosarcomas with 90Sr in CF1 mice is associated with the expression of ecotropic type-C RNA viruses devoid of sarcomatogenic activity. In contrast, the FBR murine osteosarcoma virus complex, isolated from a 90 Sr-induced osteosarcoma of a X/Gf mouse [M. Finkel et al. (1)], causes the rapid appearance of osteosarcomas in newborn mice and transforms fibroblasts in vitro. The transforming capacity of FBR murine sarcoma virus has been associated as an oncogene homologous to v-fos.

Published
1984

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