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1. [Bactericidal effects of macrophages of mice treated with interferon].

Author

Oishi K, Imanishi J, and Kishida T

Subjects
Animals, Macrophages drug effects, Mice, Mice, Inbred ICR, Staphylococcus aureus, Bacteria, Interferons pharmacology, Macrophages immunology
Abstract

The preparations of interferon or virus-inhibiting factor produced in L cell (L-IF) and mouse brain (MB-IF) enhanced the killing of Staphylococcus aureus (S.a.) by the mouse peritoneal macrophage. The L-IF, heat-inactivated at 80 degrees or 60 degrees for 30 min., and mock L-IF could not enhance the killing of S.a. The heterologous human and rabbit interferon preparations didn't enhance the bactericidal activity of macrophage. The L-IF didn't have any effect on the release of lysozyme from the macrophages.

Published
1979

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