1. [Hyperoctanoatemia and the hepatic encephalopathy of cirrhosis. 150 dosages in 61 patients (author's transl)].
- Author
-
Staeffen J, Rabinowitz JL, Aumonier P, Ballan P, Ferrer J, Terme R, Seriès C, and Myerson RM
- Subjects
- Adult, Animals, Caprylates biosynthesis, Caprylates pharmacology, Chromatography, Gas methods, Coma chemically induced, Fatty Acids metabolism, Haplorhini, Humans, Mass Spectrometry, Caprylates blood, Hepatic Encephalopathy blood, Hepatic Encephalopathy complications, Liver Cirrhosis complications
- Abstract
A new and sensitive method for determination of octanoate in serum by gas-liquid chromatography is described. It was validated by mass spectrometry. Octanoate concentrations were determined in the serum of 61 fasting cirrhotic patients of which 47 also had hepatic encephalopathy. Concentrations in arterial and venous blood were higher in cirrhotic patients with encephalopathy than in those without and higher in the latter than in controls. Arterial concentrations were higher than venous concentrations and octanoate and ammonia varied independently. A predominant endogenous origin is likely. Data obtained from studies using palmitic acid labeled at different loci suggest that recovered serum octanoate was formed mostly by incomplete oxidation of long chain fatty acids. Sodium octanoate infusion to rhesus monkeys studied polygraphically induces a temporary coma.
- Published
- 1979