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In this minireview, we overview a computational pipeline developed within the framework of NCCR Catalysis that can be used to successfully reproduce the enantiomeric ratios of homogeneous catalytic reactions. At the core of this pipeline is the SCINE Molassembler module, a graph-based software that provides algorithms for molecular construction of all periodic table elements. With this pipeline, we are able to simultaneously functionalizenand generate ensembles of transition state conformers, which permits facile exploration of the influencenof various substituents on the overall enantiomeric ratio. This allows preconceived back-of-the-envelope designnmodels to be tested and subsequently refined by providing quick and reliable access to energetically low-lyingntransition states, which represents a key step in undertaking in silico catalyst optimization.

Amongst scholars in Internet Studies (IS), Marx’s work on alienation has generally remained in favour. Its development in the field, however, has been uneven. Competing traditions claim alternative moments of alienation germane to their program and objects of study. This essay identifies and evaluates contemporary thinking concerned with alienation and high-technology capitalism. From the findings, I suggest a theory of alienation in digital communication that highlights the skill invested in users through human-technology co-developmental processes.

Tris(dioxime) iron(II) clathrochelate complexes functionalised with 3- and 4-pyridyl groups have been employed as building blocks in the preparation of supramolecular structures by coordination-driven self-assembly. These complexes possess a number of desirable characteristics, being straightforward to synthesise and offering ample opportunity for steric and functional modification. Clathrochelate-based 4,4'-bipyridyl metalloligands from 1.5 nm to 5.4 nm in length were prepared in up to two steps and their potential as building blocks for supramolecular architectures demonstrated through the preparation of a discrete molecular square and a three dimensional (3D) coordination polymer. Furthermore, the structure-directing capability of clathrochelate building blocks was illustrated through the synthesis of octahedral cage compounds, which are capable of encapsulating the large, hydrophobic BPh4– anion in aqueous solvent mixtures.

Implication Statement Thriving Together, a workshop for first year medical students, addresses crucial aspects of class culture early into medical school. Through small group discussions, this student-led event creates a safe space for open dialogue and self-reflection. Participants gain valuable insights into classmates’ perspectives and how to foster communication, empathy, and improved class cultures. These lessons are likely to transfer into future practice through enhanced conflict-resolution and relationship-building skills, contributing to higher-quality patient care. Because Thriving Together can readily be adopted elsewhere, we encourage other medical schools to conduct similar workshops to help in addressing an otherwise neglected aspect of medical education.

Controlling surface water runoff is one way to maintain environmental sustainability. Rainwater on the road surface is one of the problems that must be controlled. Most road surfaces are covered with waterproof material so that rainwater cannot infiltrate into the ground, which then accumulates and causes flooding. This research aims to study porous concrete paving blocks to prevent flooding. This paving block material is made from a coarse aggregate of 4 – 9.5 mm as the main component for making porous concrete paving blocks with height variations of 6 cm, 8 cm, and 10 cm. Concrete Paving Block is used to compare the performance of Porous Concrete Paving Block. Compression, porosity, and infiltration rate tests have been carried out to see its characteristics. Based on tests that have been carried out, porous concrete paving blocks have a porosity ranging from 19 - 23% and an infiltration rate ranging from 0.17 - 0.42 cm/second; however, porous concrete paving blocks experience a decrease in compressive strength of 58 - 60% when compared to concrete paving blocks conventional.

Implication Statement Medical schools have a responsibility to ensure students meet and advocate for the needs of the community. However, addressing the social determinants of health is not always emphasized in clinical learning objectives. Learning logs are useful tools that can engage students to reflect on clinical encounters and direct students in their learning to target the development of highlighted skills. Despite their efficacy, the use of learning logs in medical education is largely applied towards biomedical knowledge and procedural skills. Thus, students may lack competence to address the psychosocial challenges involved in comprehensive medical care. Social accountability experiential logs were developed for third year medical students at the University of Ottawa to address and intervene on the social determinants of health. Students completed quality improvement surveys and results demonstrated this initiative to be beneficial to their learning and contributed to greater clinical confidence. Experiential logs in clinical training can be adapted across other medical schools and tailored to fit the needs and priorities of each institution’s local communities.

Given how often physicists talk about beauty, the author tries to understand what they are talking about, what they mean, and whether or not there is any truth to what they are saying. The main questions he addresses are: When discussing the nature and beauty of physics, are we doing physics, science, psychology, or philosophy? And, does the meaning of the physicists’ acclamations actually line up with the true nature of beauty? The author concludes that there can be truth in the statement that there is beauty in physics, and the physicists themselves would be able to say most authoritatively which theories are beautiful and which are not.

This article examines the way Augustine draws on the theological virtue of hope to address how people should live in times of suffering. Of the three theological virtues – faith, hope, and love – hope is the least explored theme in contemporary Augustinian scholarship. This article develops a framework for Augustine’s model of hope from his Enchiridion and then applies it to select Sermons and Letters. Through this, we see that for Augustine hope does not represent either an anesthetizing, otherworldly vision that neglects suffering or an extreme ascetic embrace of suffering. Rather, hope seeks the transcendent good that acknowledges the profound depth of suffering while also maintaining a vision of happiness to come. Here, Augustine draws on hope to maintain a tension between temporal and eternal life, between the present reality of suffering and the future hope of happiness. We will also see a close connection between hope and its compatriots of faith and love, a connection Augustine utilizes to explore how hope transforms the moral and spiritual principles that guide our actions in the world.

The term “genus” has evolved over time. This paper traces development of the word from the common usage of Ancient Greece, through the pre-Socratic philosophers and Plato, and up to the more technical use in Aristotle. It began in common use to mean a class or race of people, most specifically referring to people with a common parentage. The pre-Socratics applied the term to refer to things that were generated. Plato used the term to refer to groups of people generated by a common interest or aim. Aristotle employed it in different ways based on his predecessors. This paper makes comparisons between these usages and the philosophy of Thomas Aquinas. It argues that understanding the development of “genus” facilitates understanding how Thomas Aquinas used it.

Under the editorship of Margaret Gatty (1809-1873)—an amateur naturalist and the author of several didactic fairy-stories—a new monthly, six-penny magazine was launched in 1866: Aunt Judy’s Magazine. By the time of its first issue, the Hospital for Sick Children at Great Ormond Street (GOSH) had already been serving impoverished children for fourteen years. Dr Charles West founded the hospital in 1852 and it quickly became popular with philanthropists, most notably, in the early years, Charles Dickens who described the hospital as counteracting the destructive effects of the ‘Grim Nurses: Poverty and Sickness’. Shortly after the founding of the magazine, in 1868, ‘Aunt Judy,’ the editorial persona used in the magazine, used the rapport she had built up with her child readers to encourage them to donate to GOSH. The magazine and its readers would go on to raise thousands of pounds in individual donations and monthly, quarterly, and annual subscriptions to establish several ‘Aunt Judy’s Cots’ for poor, sick children, in addition to helping with the construction of a new wing of the hospital. This essay does not analyze how Aunt Judy’s Magazine helped the hospital but investigates the ways the ‘Correspondence’ pages were used for the ideological work of creating a new generation of middle-class philanthropists. The analysis of the correspondence pages of Aunt Judy’s Magazine reveals how the conversational tone of the fictional persona of ‘Aunt Judy’ helped build a trusting relationship with the child readers which was instrumental in recruiting them to fight the ‘Grim Nurses’.

a poem and translation

This paper seeks to explain the extraordinary violence of modern-day organized white supremacism in the United States. We begin on a conceptual level by distinguishing the racial ideologies and violence associated with modern racist movements from the racism and racial violence expressed in daily life in highly racialized and racially unequal societies. We then move to an empirical level by using our interviews with a broad set of former racist activists to explore how violence is caused by—and also can cause—the vicious racist ideologies of modern white supremacism.

Recensione del libro The Hotel: Occupied Space di Robert A. Davidson.

INTRODUCTION: Rabies is a fatal neglected zoonosis killing 55,000 people worldwide annually. It is endemic in Nigeria with 10,000 people exposed annually through dog-bites. To inform adequate intervention due to the rise in reported dog-bite cases, we assessed knowledge, attitudes and practices (KAP). METHODS: we carried out a cross-sectional study among 224 residents of Abuja Municipal Area Council. We used structured questionnaires to collect data on sociodemographic characteristics, knowledge and attitudes on rabies prevention. Knowledge score of ≥ 8 points based on ten-point domain questions were regarded as satisfactory. We analyzed data using Epi-Info and Excel for frequencies and proportions and associations were determined at 5% significance level. RESULTS: a total of 123 (55%) respondents owned dogs. One hundred and eighty-four (82%) respondents had satisfactory knowledge on rabies prevention. About 87% knew where to get dogs vaccinated and would seek medical treatment from the hospital when bitten by a dog. Majority (58%) did not know the frequency of anti-rabies administration for dogs and 63.3% did not know the appropriate first aid actions following dog-bites. Of 123 dog owners, 35% would allow their dogs roam without restriction and 94% reported vaccinating their dogs against rabies. Dog owners were more likely to have satisfactory knowledge of rabies compared to non-dog owners (OR 7.8, 95% CI 1.0-62.0, p = 0.02). CONCLUSION: knowledge on rabies is satisfactory but with knowledge gaps in the frequency of dog anti-rabies vaccination, appropriate first-aid following dog bites and non-restriction of dog movement. To prevent rabies, these knowledge gaps need to be addressed through public enlightenment and enforcement of dog movement restrictions laws.

Modern access to justice scholarship takes as its premise that the focus of legal reform must be on the legal problems experienced in the day-to-day lives of the public; not just those problems that are brought before the formal court system for adjudication. In 2014, the Canadian Forum on Civil Justice [CFCJ] completed a comprehensive survey for the Cost of Justice Project inquiring into the civil legal needs among ordinary Canadians. One of the many conclusions that can be drawn from the survey data is the finding that most Ontarians do not go to lawyers in order to resolve their legal problems. Ontarians, rather, tend to engage in methods of resolution that can be categorized as informal self-help methods. This paper explores possible reasons why Ontarians do not seek out formal legal advice when they experience a legal problem. It examines various factors that may influence Ontarians’ decision not to seek formal legal advice including the respondents’ income level, their perception of the law and the category of legal problem experienced. The paper concludes that most Ontarians seek to resolve their legal problems through informal self-help methods, not because of their inability to afford legal services, but rather because of how legal problems are perceived. This work will provide insight into why most legal problems do not end up before the formal legal system, which will be of significance to policy makers who desire to make meaningful and inclusive reforms to the justice system.

This paper takes up Jung’s concept of Alchemy and applies the theory of this transformational process to prison psychotherapy. In particular, it discusses the manifest meanings in the prison system, how those can be made present and manifest, and how psychotherapy can prove an event, a moment when transformation can take place. It then discusses the openness and closedness of the client and the therapist to the transformational possibilities of the event, and the consequences of those fluid positions. Contextualizing the degree of openness is the adjacent possible in this potentially very human form of relating, and how the apparatus of prisons situated within a broader culture informs the transformational alchemy of forensic psychotherapy. Este artículo recoge el concepto de alquimia de Jung, y aplica la teoría de este proceso transformativo a la psicoterapia de prisiones. En particular, se tratan los significados evidentes del sistema de prisiones, cómo éstos se pueden hacer presentes y evidentes, y cómo la psicoterapia puede probar un evento, un momento en el que la transformación puede tener lugar. Seguidamente analiza la apertura y cerrazón del cliente y el terapeuta a las posibilidades transformadoras del evento, y las consecuencias de esas posiciones flexibles. Contextualizar el grado de apertura es el adyacente posible en esta forma potencialmente muy humana de relacionarse, y cómo el sistema de prisiones situado en una cultura más amplia, informa de la alquimia transformacional de la psicoterapia forense. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=2624907

This paper takes up Jung’s concept of Alchemy and applies the theory of this transformational process to prison psychotherapy. In particular, it discusses the manifest meanings in the prison system, how those can be made present and manifest, and how psychotherapy can prove an event, a moment when transformation can take place. It then discusses the openness and closedness of the client and the therapist to the transformational possibilities of the event, and the consequences of those fluid positions. Contextualizing the degree of openness is the adjacent possible in this potentially very human form of relating, and how the apparatus of prisons situated within a broader culture informs the transformational alchemy of forensic psychotherapy. Este artículo recoge el concepto de alquimia de Jung, y aplica la teoría de este proceso transformativo a la psicoterapia de prisiones. En particular, se tratan los significados evidentes del sistema de prisiones, cómo éstos se pueden hacer presentes y evidentes, y cómo la psicoterapia puede probar un evento, un momento en el que la transformación puede tener lugar. Seguidamente analiza la apertura y cerrazón del cliente y el terapeuta a las posibilidades transformadoras del evento, y las consecuencias de esas posiciones flexibles. Contextualizar el grado de apertura es el adyacente posible en esta forma potencialmente muy humana de relacionarse, y cómo el sistema de prisiones situado en una cultura más amplia, informa de la alquimia transformacional de la psicoterapia forense. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=2624907

Introduction: We sought to determine the difference between Canadian CT Head Rule (CCHR) indicated imaging rates and actual imaging rates for patients with mild traumatic brain injuries (mTBIs) at a rural emergency department (ED) without in-house computed tomography (CT). In addition, we compared CCHR adherence at a hospital without CT to previous publications from centres with CT to determine if rural populations receive less CT imaging for minor head traumas when indicated by the CCHR., Methods: This retrospective chart review explored individuals who presented to a rural ED (no in-house CT scanner) with a primary diagnosis of mild head injury or concussion between 1 January 2017 and 31 December 2021. Information regarding CCHR criteria, transfer status and patient demographics was collected. Descriptive analyses were completed to determine the percentage of patients who received appropriate transfer for imaging, did not receive transfer for imaging when indicated and received unnecessary transfer., Results: A total of 124 charts met our inclusion criteria (17 [12.1%] charts excluded), with 25.8% transferred to the nearest hospital for CT imaging. After applying the CCHR criteria to our charts, 62.1% were indicated for CT. Of the 62.1%, only 35.1% were transferred for imaging (51.2% of high-risk and 16.7% of medium-risk)., Conclusion: By exploring CT rates for mTBIs in a rural Canadian ED, we found low transfer rates (35.1%) of CCHR-indicated patients for imaging needed to guide further healthcare decisions. This work highlights a discrepancy within the Canadian healthcare system between rural and urban centres and allows for opportunities to help narrow the gap in health care., Introduction: Nous avons cherché à déterminer la différence entre les taux d'imagerie indiqués par le Canadian CT Head Rule (CCHR, règlement canadien relatif à la tomodensitométrie de la tête) et les taux d'imagerie réels pour les patients souffrant de traumatismes craniocérébraux légers (TCCL) dans un service d'urgence rural ne disposant pas d'une tomographie par ordinateur interne. En outre, nous avons comparé l'adhésion au CCHR dans un hôpital sans tomographie par ordinateur à des publications antérieures provenant de centres avec tomographie par ordinateur afin de déterminer si les populations rurales reçoivent moins d'imagerie par tomodensitométrie pour les traumatismes crâniens mineurs lorsque le CCHR l'indique., Mthodes: Cette étude rétrospective des dossiers a exploré les personnes qui SE sont présentées à une urgence rurale (sans tomodensitomètre interne) avec un diagnostic primaire de traumatisme crânien léger ou de commotion cérébrale entre le 1er janvier 2017 et le 31 décembre 2021. Les informations concernant les critères du CCHR, l'état de transfert et les données démographiques des patients ont été recueillies. Des analyses descriptives ont été réalisées pour déterminer le pourcentage de patients ayant reçu un transfert approprié pour l'imagerie, n'ayant pas reçu de transfert pour l'imagerie quand c'était indiqué et ayant reçu un transfert inutile., Rsultats: Au total, 124 dossiers répondaient à nos critères d'inclusion [17 (12,1%) dossiers exclus], dont 25,8% ont été transférés à l'hôpital le plus proche pour une imagerie par tomodensitométrie. Après avoir appliqué les critères du CCHR à nos dossiers, 62,1% d'entre eux étaient indiqués pour une tomodensitométrie. Sur ces 62,1%, seuls 35,1% ont été transférés pour imagerie (51,2% de haut risque, 16,7% de risque moyen)., Conclusion: En explorant les taux de tomodensitométrie pour les TCCL dans un service d'urgence rural canadien, nous avons constaté de faibles taux de transfert (35,1%) des patients recommandés par le CCRH pour une imagerie nécessaire dans le but de guider les décisions de soins de santé ultérieures. Ce travail met en évidence un écart dans le système de santé canadien entre les centres ruraux et urbains et offre des opportunités pour aider à réduire l'écart dans les soins de santé., (Copyright © 2024 Copyright: © 2024 Society of Rural Physicians of Canada.)