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3 results on '"MESH: Meningeal Neoplasms"'

1. [MR and CT perfusion imaging of the brain: principles and clinical applications]

Author

Grand, Sylvie, Lefournier, Virginie, Krainik, Alexandre, Bessou, P., Tropres, Irène, Chabardes, Stephan, Hoffmann, Dominique, Le Bas, Jean-François, Département de neuro-radiologie, CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Service d'Imagerie par Résonance Magnétique (IRM), CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF), Département de neurochirurgie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, and Issartel, Jean-Paul

Subjects
Male, MESH: Cerebral Hemorrhage, Lymphoma, MESH: Brain Diseases, Gadolinium, MESH: Meningioma, Brain Ischemia, MESH: Magnetic Resonance Imaging, MESH: Glioma, Meningeal Neoplasms, Melanoma, MESH: Aged, Brain Diseases, MESH: Middle Aged, Brain Neoplasms, MESH: Brain Ischemia, Glioma, MESH: Follow-Up Studies, Middle Aged, Magnetic Resonance Imaging, Perfusion, Child, Preschool, Acute Disease, MESH: Brain Neoplasms, MESH: Acute Disease, Female, MESH: Cerebrovascular Disorders, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Meningioma, MESH: Tomography, X-Ray Computed, MESH: Perfusion, Adult, MESH: Melanoma, Oligodendroglioma, Brain Abscess, MESH: Brain Abscess, Astrocytoma, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], cardiovascular diseases, MESH: Oligodendroglioma, Aged, Cerebral Hemorrhage, MESH: Humans, MESH: Child, Preschool, MESH: Adult, MESH: Meningeal Neoplasms, MESH: Male, Cerebrovascular Disorders, MESH: Astrocytoma, Tomography, X-Ray Computed, MESH: Gadolinium, MESH: Lymphoma, MESH: Female, Follow-Up Studies
Abstract

International audience; MR and CT imaging techniques provide both morphological data and functional data. MR and recently CT perfusion have substantially modified the treatment of acute stroke. CT perfusion offers new opportunities to improve the management strategy in vasospasm after subarachnoid hemorrhage. Both are also helpful for the diagnosis of brain tumors and the assessment of treatment effects.

Published
2007

2. [Early detection of leptomeningeal metastasis in patients with metastatic breast carcinoma: validation of CA 15-3 measurement in cerebrospinal fluid]

Author

Gauchez, Anne Sophie, Pez, Emilie, Boutonnat, Jean, Bourre, Jean Cyril, Pelletier, Laurent, Payan, Raoul, Mousseau, Mireille, Issartel, Jean-Paul, Département de biologie intégrée, CHU Grenoble-Hôpital Michallon, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), EPHE, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Biophysique et Médecine Nucléaire, CHU Grenoble, Laboratoire de Recherche sur la Motivation Humaine, University of Ottawa [Ottawa], Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinique Belledonne, Service d'oncologie médicale, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), and VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)

Subjects
MESH: Mucin-1, Receptor, ErbB-2, Antineoplastic Agents, Breast Neoplasms, Antibodies, Monoclonal, Humanized, MESH: Antibodies, Monoclonal, MESH: Magnetic Resonance Imaging, Biomarkers, Tumor, Meningeal Neoplasms, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neoplasm Metastasis, skin and connective tissue diseases, MESH: Humans, Mucin-1, Antibodies, Monoclonal, Reproducibility of Results, Trastuzumab, MESH: Meningeal Neoplasms, Magnetic Resonance Imaging, MESH: Neoplasm Metastasis, MESH: Reproducibility of Results, MESH: Receptor, erbB-2, MESH: Tumor Markers, Biological, MESH: Antineoplastic Agents, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Female, MESH: Breast Neoplasms
Abstract

International audience; Fifteen per cent of metastatic breast cancer will develop symptomatic leptomeningeal metastases. The introduction of trastuzumab (Herceptin) therapy has improved the response rates of survival of patients with metastatic breast cancer overexpressing HER2. Although previous studies are retrospective and of limited number, involving small study groups and different types of patient management, several authors have reported a 30% incidence of leptomeningeal metastases in patients with metastatic breast cancer overexpressing HER2 who were treated with trastuzumab, while 70 to 80% of cases of the disease were controlled systemically. In order to improve control of the disease at the level of the central nervous system (CNS), routine detection of leptomeningeal metastases in high-risk patients could be offered. CA 15-3 in cerebrospinal fluid (CSF) detection might be useful in helping to diagnose CNS metastases, particularly where cytology results are negative--which applies to 30% of cases--because tumor markers are more sensitive in detecting the tumor process. Our study validate CA 15-3 measurement in CSF and reference values were given.

Published
2007

3. [Perfusion MR imaging for initial diagnosis and follow-up of brain tumors]

Author

Le Bas, Jean-François, Grand, Sylvie, Kremer, Stéphane, Tropres, Irène, Jiang, Z., Krainik, Alexandre, Rémy, Chantal, Berger, François, Benabid, Alim-Louis, Service d'Imagerie par Résonance Magnétique (IRM), CHU Grenoble, Département de neuro-radiologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Service de radiologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], RMN biomédicale : de la cellule à l'homme (RBCH), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-DIR CENTRALE DU SSA-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Sino-Français, Neuroimagerie Fonctionnelle et Metabolique, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'oncologie médicale, Département de neurochirurgie, Dojat, Michel, and CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF)

Subjects
Male, Lymphoma, Biopsy, Oligodendroglioma, perfusion imaging, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Meningioma, Astrocytoma, MESH: Tomography, Emission-Computed, Single-Photon, MESH: Magnetic Resonance Imaging, MESH: Glioma, Diagnosis, Differential, MESH: Biopsy, MESH: Brain, [SDV.CAN] Life Sciences [q-bio]/Cancer, MESH: Diagnosis, Differential, Meningeal Neoplasms, Humans, MESH: Oligodendroglioma, oligodendrogliomas, Neoplasm Staging, Tomography, Emission-Computed, Single-Photon, MESH: Middle Aged, MESH: Humans, Brain Neoplasms, Brain, MESH: Neoplasm Staging, MESH: Cerebrovascular Circulation, MESH: Follow-Up Studies, Glioma, Middle Aged, MESH: Meningeal Neoplasms, Magnetic Resonance Imaging, MESH: Male, MESH: Astrocytoma, Cerebrovascular Circulation, MESH: Brain Neoplasms, Female, MESH: Lymphoma, Meningioma, MESH: Female, brain tumor, MRI, Follow-Up Studies
Abstract

National audience; OBJECT: To discuss the pertinency of perfusion MR imaging for initial diagnosis and follow up of brain tumors. METHODOLOGY: Dynamic susceptibility contrast MR imaging was applied. Images were thus obtained with intensities proportional to the cerebral blood volume (CBV). Relative cerebral blood volume (rCBV) maps were then generated by normalizing the signal intensities with respect to measurements made in healthy tissue. RESULTS: The method provided interesting data for establishing the differential diagnosis between different kinds of lesions, in particular between lymphoma and pilocytic astrocytoma, and for grading gliomas. DISCUSSION AND CONCLUSION: Limits of the approach are discussed, in particular with respect to quantification aspects and interpretation of the results. The approach could be particularly useful for grading oligodendrogliomas, for which histological diagnosis on biopsy is sometimes difficult.

Published
2005

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