To combine the economic viability of urban areas with a quantitative condition that can characterize “epidemic” and “Pandemic” diseases, we use the factor analysis method to achieve index dimensionality reduction and subjective and objective integration method to achieve optimal weight distribution. We develop a judgment model by taking into account broad factors such as the epidemic situation, population, medical care, economy, and policy. On this basis, we chose 15 common infectious diseases as detection data and used the judgment model to obtain the specific quantitative judgment conditions of “spread, outbreak, epidemic, and pandemic.” The threshold for defining epidemics is between 3 and 5, and the threshold for defining pandemics is greater than 5.