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Medical isotope test reactor is the first reactor in the world. In order to implement the principle of minimizing radioactive waste, the radioactive waste liquid adopts advanced drying and salt formation technology. According to the current dry salt formation technology a number of problems arise due to the complexity of the feedstock waste stream. In this study, a thermodynamic electrolyte simulation model was developed and its predictive accuracy was verified for complex electrolyte systems. Then, sensitivity analysis and discussion of the operating parameters such as temperature, pH and salt adjustment of the dry salting technology are presented. The new approach of the thermodynamic electrolyte simulation model has been used to improve and optimise the safety aspects of the technology and the associated process configuration. It provides a certain general idea and follow-up theoretical guidance for drying salt formation technology.