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International audience; UNLABELLED: Human coronaviruses (HCoV) have been implicated in neonatal nosocomial respiratory infection. Prior to our study, several cases of neonatal infection were observed in infants born at our hospital. This prospective pilot monocentric pilot study investigates the possibility of maternofetal transmission of HCoV responsible for cases of neonatal infection observed within the first 24 hours of life. MATERIALS AND METHODS: Three samples from mother-child couples, maternal vaginal (VM) and respiratory (RM) samples during labor; newborn gastric sample (GNN), were assessed for viral analysis using real time RT-PCR for the detection of HCoV 229-E and OC43. Clinical follow-up of infants and mothers was up to Day 3 after birth. RESULTS: One hundred (and) fifty-nine mother-child couples were included between July 2003 and August 2005. HCoV 229-E only was detected in 11 samples from 6 mother-child couples. For 2 couples, all 3 samples (VM, RM and GNN) were tested positive (cases 1 and 2). For case 3, both VM and GNN were positive. For 2 couples, only RM was positive (cases 4 and 5). In case 6, only VM was positive. Of the 3 positive GNN, no infant was symptomatic. CONCLUSION: Possible vertical transmission of HCoV was evidenced in this pilot study and requires further investigation on a larger scale. Equally indicated is the inclusion of tests to detect recently identified human coronaviruses HCoV NL63 and HKU1, as well as genomic profile analysis of HCoV 229-E detected in the 3 positive mother-child couples.

National audience

Maunaye Marcel, Marchand Roger, Guyader Jean, Laurent Yves, Lang Jean. Structure de Mn Si N2 et Mn Ge N2. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 94, 5-6, 1971. pp. 561-564.

The structures of the two nitrides MgSiN₂ and MgGeN₂ have been investigated by X-ray powder methods. Both compounds are similar to BeSiN₂, and crystallise in the orthorhombic system in the space group Pna2₁. The R Factor calculated for non-zero data is 0.085 for MgSiN₂ and 0.0645 for MgGeN₂. These nitrides are related to the wurtzite-type structure and belong to the same family as BeSiN₂ and oxygen compounds such as LiGaO₂ and β-NaFeO₂., Les structures des deux nitrures MgSiN₂ et MgGeN₂ ont été étudiées à l'aide des diagrammes de poudre. Ces deux composés sont isotypes de BeSiN₂ et cristallisent dans le système orthorhombique. Le groupe spatial est Pna2₁ Le facteur R calculé en tenant compte de toutes les raies observées est 0,085 pour MgSiN₂ et 0,0645 pour MgGeN₂. Ces nitrures dérivent de la structure type wurtzite et forment une famille isostructurale avec BeSiN₂ et les composés oxygénés LiGaO₂ et β NaFeO₂., David Jean, Laurent Yves, Lang Jean. Structure de Mg Si N2 et Mg Ge N2. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 93, 2, 1970. pp. 153-159.