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The Costa Maya is a vernacular coastal region of southeastern Quintana Roo (Mexico) and adjacent Ambergris Cay, Belize. As Mexico’s Caribbean coast suffered many growth pains associated with mass tourism development in Cancun and along the Riviera Maya, the Costa Maya by contrast was projected for more sustainable development including low-density housing and ecotourism. Development so far has been concentrated in Puerto Costa Maya, where a cruise ship pier and terminal were built in 2001. The nearby beach resort (balneario) of Majahual became dependent upon the 10-12 shiploads of tourists that descended upon it every week. In spite of big development plans, the more remote beaches of the Costa Maya cater to fewer, but well-heeled ecotourists and dive tourists. Hurricane Dean made landfall in August 2007 as a category-5 storm, and economic recovery only began in late 2008 when the cruise ship pier re-opened and Majahual rebuilt. As of late 2009, the cruise-ship traffic had still not recovered to pre-Dean levels, and a global recession coupled with swine-flu and drug violence scares has lowered U.S. tourism to Mexico. To what degree new tourism infrastructure such as an international airport at Tulum, a proposed causeway from Chetumal to the beach, and a new resort complex at Xahuayxel will stimulate tourism on the Mexican Costa Maya and eventually lead to a coastal highway link with San Pedro, Belize is still unknown.

Este artigo refere-se a um diálogo das experiências dos autores com a literatura sobre “pesquisa científica”, “produção”, “conhecimento”, “internacionalização” de pesquisadores clássicos e produções substanciais para a realização de uma reflexão crítica e analítica em contexto com a pesquisa em educação. Em específico nos processos formativos de professores, seus campos de pesquisa, inclusão e internacionalização. O objetivo deste artigo se pauta em refletir, conceituar e analisar a importância e o desenvolvimento da pesquisa sobre processos formativos de professores, gestores de políticas públicas em educação, agendas internacionais e interculturalidade para a inclusão. O trabalho admite a abordagem qualitativa com foco na interpretação dos fenômenos sociais, culturais e humanos, tem como metodologia a pesquisa bibliográfica, traduzindo em discussão aspectos que levam ao resultado da necessidade de revisões e implementações relacionadas às pesquisas científicas em educação, internacionalização e inclusão para as políticas educacionais.

The advantageous application of a falling-film microreactor for a photochemical gas/liquid reaction was demonstrated by the selective photochlorination of toluene-2,4-diisocyanate (TDI). In the microstructured reactor the selectivity to the side-chain chlorinated product 1-chloromethyl-2,4-diisocyanatobenzene (1Cl-TDI) achieved a value of 80% at 55% TDI conversion, whereas the side product toluene-5-chloro2,4-diisocyanate (5Cl-TDI) was formed with only 5% selectivity. The yield of 1Cl-TDI was enhanced by increasing the residence time from 24% after 5 s to 54% after 14 s. At the same time the formation of consecutive products increased and the selectivity to 1Cl-TDI decreased to 67% after 14 s residence time. The influence of the reactor material was shown. In presence of a Lewis acid such as FeCl3, formed by chlorination using a reaction plate made of iron, consecutive products were formed and the selectivity to 1Cl-TDI was lowered. The microstructured reactor led to remarkably higher selectivities than the conventional batch reactor, where the selectivity to 1Cl-TDI was only 45% at 65% TDI conversion and the side product 5Cl-TDI was formed with 50% selectivity. The space-time yield of 1Cl-TDI achieved in the microstructured reactor (400 mol l?1 h?1) clearly exceeded the performance of the batch reactor (space-time yield 1.3 mol l?1 h?1). Based on the microreactor data, a kinetic model for the TDI chlorination including by-product formation was suggested and used to predict product selectivity at full TDI conversion.

In a rational approach to identify an ultrapotent compound for the treatment of therapy-resistant dermatoses, Weirich's modification of McKenzie's skin vasoconstriction assay (HVK test) has been used as the essential selection criteria. In a primary phase, a quantitative relationship between the HVK activity of 25 derivatives of corticosterone substituted in various positions of the skeleton, and their lipophilicity (log P) was established. The specific lipophilicity-independent interactions were accounted for by the inclusion of 'indicator variables' into the regression analysis. The highly significant results allowed to localize an optimal log P range and to identify the influence of various substituents. In a next phase, the evidence of the first HVK analysis was refined by considering 28 additional compounds. On the basis of the confirmed facts, six 21-chloro-6?-fluoro compounds were specifically synthesized and submitted to dermatopharmacological testing. Finally, CGP 14458 (= 2l-chloro-6?,9-difluoro-11?-hydroxy-16?-methyl-3,20-dioxopregna-l,4-dien-17?-yl propionate) which was predicted to be the most potent representative of these series, whose synthesis is described in detail, showed indeed to be the most effective compound. Clinical trials with this compound – halobetasol propionate/Ultravate® (ulobetasol/Miracorten®) – confirmed its unique efficacy, especially in the treatment of severe, chronic plaque psoriasis.