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Currently, there are studies which show the separate effect of the local discomfort parameters such as the draught and radiant thermal asymmetry. However, no studies have been conducted to find out the combined effect of the before mentioned two discomfort parameters on human performance. In order to fill this gap, a 17 months experiment was performed at the Budapest University of Technology and Economics. Throughout the experiment twenty human subjects (ten women and ten men) performed different cognitive tests and responded to questionnaires. Two different draught rates and five different radiant thermal asymmetry values were imposed in the Macskásy climate chamber, where the experiment took place. The results show the consequence of the combined effect of draught and radiant thermal asymmetry on the human performance.