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Currently, despite the improvement of radiation safety measures, there is a risk of increasing frequency of radiation accidents and various disasters accompanied by explosions, fires and emissions of radionuclides. Emergencies (emergencies) of peacetime and wartime, especially accidents at radiation-hazardous facilities, including nuclear power plants, carry the danger not only of irradiation of people, but also at the same time thermal burns, mechanical injuries, chemical poisoning by harmful gorenje products, as well as other lesions. Experimental modeling of acute radiation and burn disease was carried out both separately and in combination. It was found that external total gamma irradiation of white rats at a dose of 7.5 Gy causes severe radiation sickness with characteristic clinical signs and high mortality of irradiated animals. A heat stroke simulation was performed by applying a metal plate heated to 190°C with an exposure time of 5 and 8 seconds. It turned out that the degree of burn depends on the time of contact with the surface of the body: its application within 5 seconds caused a burn of the III-A degree, an 8-second exposure of the IIIB degree, which was confirmed by the timing of formation, rejection of eshar and complete healing of the thermal lesion. The aggravating effect of ionizing radiation on the course and outcome of combined radiation-thermal pathology is demonstrated.