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As imagens presentes no webjornalismo utilizam recursos de hipermídia? Este artigo parte da constatação de que as tecnologias digitais ainda são pouco exploradas. A observação de jornais e sites jornalísticos – auxiliada pela reflexão sobre conceitos de hipertexto, hipermídia e imagem complexa – leva à escolha de algumas produções audiovisuais exemplares. Foram selecionados três especiais da seção “Multimedia” do argentino Clarin.com, que trazem caminhos inovadores, principalmente quanto ao tratamento da imagem de matriz fotográfica. Além da ampliação das potencialidades visuais, a imagem funciona como interface e conexão.

Discordances between hormone receptors and HER2 status in primary and metastatic breast cancer have been reported by several studies. In this context, systematic biopsies could be clinically relevant in breast cancer to confirm the biological characteristics of a suspicious lesion. In this article, illustrated by 2 case reports and based on a recent review on this topic, we discuss the clinical significance of receptor discordances and possible diagnosis of a secondary primary tumor. The role of these biopsies for the identification of new therapeutic targets is also envisaged as well as underlying mechanisms for receptors' modification like tumoral heterogeneity, clonal selection and technical artifacts.

The authors review the principles of systemic therapy in breast cancer. They analyze the degree of treatment individualization in our current approach. New technologies allow the detection of genomic alterations in cancer cells. Unfortunately, we do not know yet how to best use this knowledge for routine patient care. Most genomic alterations are rare events complicating further drug development. Temporal and spatial heterogeneity in tumors also has to be taken into account. An intense international collaboration is ongoing to try and demonstrate that precision medicine will really improve treatment outcome.

The long-term consequences of a neonatal exposure to diazepam (DZP) on behavioral abilities and local cerebral metabolic rates for glucose (LCMRglc) in selected brain regions involved in the control of memory and anxiety were studied in adult rats. Rat pups received a daily subcutaneous injection of 10 mg/kg DZP or of the dissolution vehicle from postnatal day (P) 2 to 21. Learning and memory were tested in P60-P70 rats on 5 consecutive days in a T maze and an eight arm maze while anxiety and reaction to novelty were tested in a 2 compartment box with a 2 step staircase on one side. Social behavior was evaluated in a condition of restricted access to food. LCMRglcs were measured at P60 by the quantitative autoradiographic [14C]deoxyglucose method. In the T maze, when performed without delay between the 2 trials, the rate of alternation was significantly lower in DZP than in vehicle-exposed rats on the first 2 days of testing and similar in both groups on days 3-5. In the procedure with a 30 s intertrial delay, the rate of alternation was similar in DZP and vehicle-treated rats on all days of testing. In the eight arm maze, DZP-treated rats were more active, i.e. entering more arms per min than control animals. The number of arms entered before the first error was lower on day 1 and higher on day 3 in DZP compared to vehicle-exposed rats. In the 2 compartment box, DZP-treated rats crossed more often the lower step of the staircase and spent more time than controls on the 2 steps of the staircase while control rats made more rearings than DZP-exposed rats in the well protected corner of the box. LCMRglcs were decreased by early DZP exposure in several cortical regions, mammillary body, septum and dorsomedian caudate nucleus. In conclusion, an early chronic DZP treatment induces an increase in activity, only a delay but no impairment in learning and leads to a decrease in the level of anxiety and emotionality leading to an active response to novelty. These quite subtle behavioral changes are accompanied by discrete metabolic changes and probably reflect the state of hyperactivity/hyperarousal of these animals which could result from a change in the distribution, the sensitivity and/or function of GABA-BZD receptors.