1. [Influenza A: H1N1 post-viral membranoproliferative glomerulonephritis occurring in aggressive systemic mastocytosis: Case report and literature review]
- Author
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Quentin, Bodard, Patricia, Rullier, Hélène, Perrochia, Moglie, Le Quintrec, Mélissa, Alamé, Olivier, Hermine, Philippe, Guilpain, and Alexandre, Maria
- Subjects
Male ,Glomerulonephritis ,Influenza A Virus, H1N1 Subtype ,Mastocytosis, Systemic ,Glomerulonephritis, Membranoproliferative ,Influenza, Human ,Humans ,Female - Abstract
Systemic mastocytosis is characterised by tissular infiltration and a cytokine storm due to mast cells excessive proliferation and activation. Herein, we report an extraordinary case of AH1N1 influenza post-viral glomerulonephritis occurring in the course of an aggressive systemic mastocytosis with an associated hematological neoplasm. Because of a multisystemic involvement including the liver and lungs, we treated mastocytosis with midostaurin (multiple inhibitor of kinase protein), anti H1/H2 blockers and dexamethasone as first line treatment. One month later and despite vaccination, he developed a severe acute lung injury with respiratory distress due to AH1N1 influenza in association with the nephrotic syndrome. Kidney biopsy disclosed a membranoproliferative glomerulonephritis that was successfully treated with mycophenolate mofetil. Only a few cases of influenza post-viral or post-vaccination glomerulonephritis are documented in the medical literature. This is an exceptional association of uncommon conditions occurring within only a few months in the same patient.
- Published
- 2021