1. [Regulation of E-cadherin by the Akt protein kinase B].
- Author
-
Grille S, Bellacosa A, and Larue L
- Subjects
- Animals, Cadherins genetics, Gene Expression Regulation physiology, Humans, Models, Biological, Phosphorylation, Proto-Oncogene Proteins c-akt, Vimentin physiology, Cadherins physiology, Protein Serine-Threonine Kinases metabolism, Proto-Oncogene Proteins metabolism
- Abstract
E-cadherin is a cell adhesion molecule that is present in most normal epithelial cells. During malignant transformation, the expression of E-cadherin is frequently repressed. This protein is considered as a tumor-suppressor. The oncogenic form of Akt, a serine-threonine kinase, is multifunctionnal. One of its function is to induce the transcriptional repression of E-cadherin. This transcriptional repression induces cellular responses, epithelial cells becoming mesenchymal and invasive. At the molecular level, cells expressing a constitutive active form of Akt express also a transcription factor, Snail, known to repress the expression of E-cadherin.
- Published
- 2004