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Objective: We carried out this study in order to evaluate the effectiveness and the safety of the two H1N1 vaccines available in Tunisia: Focetria® and Panenza®., Methods: It's a prospective epidemiological study including 601 vaccinated subjects. The vaccine effectiveness was based on the occurrence of flu clinical symptoms after vaccination. The safety was based on the occurrence of unexpected events after vaccines administration. The vaccines imputability was established according to Begaud et al., Results: The number of subjects vaccinated by Focetria® is more important than Panenza®. The efficiency of vaccines would be 93.6%. Neither the medical statue nor the type of the vaccine used influence the occurrence of a flu episode after vaccination. We recorded 406 adverse effects (32.4%) with a high score of imputability (I3). Focetria® adverse effects were more frequent than Panenza® ones (p=0.009). Almost all adverse events disappeared within few days., Conclusion: The two vaccines used in Tunisia remain enough efficient to face the influenza (H1N1) pandemia and are well tolerated independently of the demographic and pathological statue of the vaccinated person as well as nature of the vaccine used., (Copyright © 2011 Société Française de Pharmacologie et de Thérapeutique. Publié par Elsevier Masson SAS.)

Aim: Study the epidemiological, clinical, biological and chronological drug rash with eosinophilia and systemic symptoms (DRESS) characteristic and indicate the implicated drugs., Methods: We carried a retrospective study including all DRESS cases notified to the Pharmacovigilance Unit of Monastir., Results: Our cohort of eleven patients had a median age of 40 years. Clinical examination revealed skin eruption and fever among all patients. Laboratory findings showed marked eosinophilia among all patients, hepatic cytolysis among eight patients and creatinin serum level increase among four patients. An interstitial pulmonary syndrome was noted among two patients. After culprit-drug withdrawal, outcomes were favorable for all patients. Skin tests were positive with carbamazepin and cefotaxim and negative with sulfasalazine, allopurinol and terbinafine., Conclusion: Throughout this paper, we point out the contribution of skin tests to identify implicated drug in inducing DRESS and to testify cross reactivity and we point out the possibility of neosensitisation to a non related chemical drug after DRESS syndrome., (Copyright © 2010 Société Française de Pharmacologie et de Thérapeutique. Publié par Elsevier Masson SAS.)