16 results on '"Fellous, Marc"'
Search Results
2. Potential environmental impacts associated with large-scale herbicide-tolerant GM oilseed rape crops
- Author
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Fellous Marc and Messéan Antoine
- Subjects
Biomolecular Engineering Commission ,environmental risks ,Oils, fats, and waxes ,TP670-699 - Abstract
The Biomolecular Engineering Commission considers that the knowledge acquired in the last three years has provided significant information in reply to the points raised in its review dated 16 February 2001. The Commission has studied the potential environmental impacts associated with large-scale herbicidetolerantGMoilseed rape crops, making a distinction between direct and indirect impacts. Direct impacts stem from the intrinsic properties of herbicide-tolerant GM oilseed rape crops whereas indirect impacts result from practices associated with the farming of these crops. The Commission considers that, in the absence of the use of the herbicide in question in and outside of farmed land, there is no direct environmental risk (development of invasive crops per se) associated with the presence of a herbicide-tolerance gene in oilseed rape (or related species). Nevertheless, since the interest of these tolerant crops lies in the use of the herbicide in question, indirect effects, to varying extents, have been identified and must be taken into account: the use of the herbicide in question, applied to agricultural fields containing the herbicide-tolerant crop could lead to an increase in oilseed rape volunteer populations in crop rotations; the selective pressure exerted by non-specific herbicides (to which the crops have been rendered tolerant) may be very high in cases of continuous and uncontrolled use of these herbicides, and may result in the persistence of rare events such as the reproduction of fertile interspecies hybrids; the change to the range of herbicides used should be conveyed by more effective weed control and, like any change in farming practices, induce indirect effects on the agri-ecosystem, particularly in terms of changes to weeds and the associated animal life. Accordingly, the Biomolecular Engineering Commission recommends a global approach in terms of the large-scale farming of herbicide-tolerant crops that: accounts for the characteristics of the herbicide and its current and future use; accounts for herbicide-tolerant varieties belonging to other species, liable to be farmed in French agriculture in the short term; targets, if applicable, the selection of crop/herbicide combinations according to the constraints associated with French agriculture; coordinates the evaluations conducted on herbicide-tolerant crops and those conducted on herbicides; implements a biovigilance system and its associated resources whenever herbicide-tolerant crop farming is envisaged. Our report highlights the need for the management of any herbicide-tolerant GM oilseed rape crops. Such a management plan must account for the diverse cropping situations, including crop rotations and farming practices. Management should be based on the prior evaluation of situations encountered, the development of measures commensurate with the risks, and a validation of their efficacy through biovigilance. The Biomolecular Engineering Commission considers that the indirect environmental and agronomic impacts associated with current management practices employed for herbicide-tolerant oilseed rape crops can only be determined, in addition to the knowledge acquired, by continuing ongoing experimental studies initiated. Mathematical and computer models – by formalizing complex scenarios that incorporate the functioning of different oilseed rape populations (farmed, spontaneous, volunteer plants) under specific farming practices – enables the simulation of potential impacts and the identification of suitable management measures. Nevertheless, at the present time, the introduction of more extensive farming than that currently practised, or managed progressive introduction, would make it possible to progress in the study of impacts and develop and validate management procedures enabling the limitation of adverse impacts. In the specific case of imports, the Biomolecular Engineering Commission considers that herbicidetolerant GM oilseed rape seed imports for processing and animal feed does not represent additional risks for the environment compared to other oilseed rape varieties on the market. Due to the very low likelihood of the dispersal of tolerant oilseed rape crops from imported seed, the impact of the herbicides used on communication routes is considered to be negligible in the current context. However, in order to supplement the information available on environmental impacts and avert any changes to the current situation, the Commission recommends that a general monitoring plan be implemented in parallel to the introduction of seeds onto the market. Finally, the Biomolecular Engineering Commission considers that biovigilance systems adapted to the various risks should be in place before any farming of commercial herbicide-tolerant varieties is undertaken. The Biomolecular Engineering Commission considers its analysis to be valid for non-selective herbicidetolerant varieties of oilseed rape obtained both by transgenesis and by means of a technique other than transgenesis.
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- 2004
- Full Text
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3. Prendre la mesure d’une culture ouverte et responsable
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Marris, Claire, Heams, Thomas, Kepes, Francois, Campos, Luis, Monsan, Pierre, Toussaint, Jean-François, Benoit-Browaeys, Dorothee, Haiech, Jacques, Alix, Jean-Pierre, Fellous, Marc, School of Social Science & Public Policy, Department of Social Science, Health & Medicine, Centre for Synthetic Biology and Innovation (CSynBI), King‘s College London, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Institut de biologie systémique et synthétique (ISSB), Université d'Évry-Val-d'Essonne (UEVE)-Génopole-Centre National de la Recherche Scientifique (CNRS), Department of History, Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA), Independent, Faculté de Médecine, Laboratoire d'Innovation Thérapeutique, Université de Strasbourg (UNISTRA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Innovation Thérapeutique (LIT), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)
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[SDV]Life Sciences [q-bio] - Abstract
Discussion Session 2Discussion Session 2; Prendre la mesure d’une culture ouverte et responsable. 3. Colloque Sciences de la vie en société
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- 2012
4. Génétique et infertilité humaine : 'une approche gènes candidats'
- Author
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Mandon-Pepin, Béatrice, Derbois, C., Matsuda, F., Cotinot, Corinne, Wolgemuth, D.J., Smith, K., McElreavey, K., Nicolas, A., Fellous, Marc, Unité biologie du développement et biotechnologie, and École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)
- Subjects
[SDV]Life Sciences [q-bio] ,GENETIQUE ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2002
5. Le déterminisme du sexe : son contrôle génetique
- Author
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Cotinot, Corinne, Pailhoux, Eric, Ottolenghi, C., Veitia, Reiner, Fellous, Marc, Unité biologie du développement et biotechnologie, École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), C. Thibault (Editeur), and M.C. Levasseur (Editeur)
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INVERSION DU SEXE ,[SDV]Life Sciences [q-bio] - Abstract
chap. 11; National audience
- Published
- 2001
6. Sex reversal in man and domestic animal. Contribution to the understanding of mammalian sex differentiation
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Pailhoux, Eric, Vaiman, Daniel, Barbaux, S., Cribiu, Edmond, Cotinot, Corinne, Fellous, Marc, ProdInra, Migration, Unité de biologie cellulaire et moléculaire, Institut National de la Recherche Agronomique (INRA), and Unité de recherche Génétique Biochimique et Cytogénétique (LGBC)
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[SDV.SA]Life Sciences [q-bio]/Agricultural sciences ,[SDV.SA] Life Sciences [q-bio]/Agricultural sciences - Abstract
3 tables 3 graph.; National audience
- Published
- 1998
7. Physiological and genetical study of polled/intersex goats. Genetic mapping of the chromosomal region involved
- Author
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CRIBIU, E.P., Vaiman, Daniel, Pailhoux, Eric, Chaffaux, Stéphane, Cotinot, Corinne, Elsen, Jean Michel, Manfredi, Eduardo, Fellous, Marc, Grosclaude, F., Unité de recherche Génétique Biochimique et Cytogénétique (LGBC), Institut National de la Recherche Agronomique (INRA), Unité de biologie cellulaire et moléculaire, Cytogénétique des Populations Animales (CPA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Station d'Amélioration Génétique des Animaux (SAGA), and ProdInra, Migration
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[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 1995
8. La determination du sexe dans l'espece humaine
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Richaud, F., McElreavey, K., Vilain, E., Abbas, N., Cotinot, Corinne, Boucekkine, C., Fellous, Marc, Unité de biologie cellulaire et moléculaire, and Institut National de la Recherche Agronomique (INRA)
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[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 1992
9. Diagnostic du sexe des embryons bovins par biologie moleculaire
- Author
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Kirszenbaum, M., Cotinot, Corinne, Leonard, Marie, VAIMAN, M., Fellous, Marc, ProdInra, Migration, Unité de biologie cellulaire et moléculaire, and Institut National de la Recherche Agronomique (INRA)
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[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,AMPLIFICATION CHAINE POLYMERASE ,BIOLOGIE MOLECULAIRE - Abstract
Supplement; National audience
- Published
- 1990
10. Génétique de l’infertilité chez l’homme, nouvelles approches.
- Author
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Fellous, Marc and Siffroi, Jean-Pierre
- Abstract
Copyright of Andrologie (11662654) is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2003
- Full Text
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11. Emmanuel Adrien Nunez (1934–2013) vient de nous quitter
- Author
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Fellous, Marc
- Published
- 2013
- Full Text
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12. Le sexage des embryons : vers une modification du sex ratio ?
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Cotinot, Corinne, Kirzenbaum, M., Vaiman, M., Fellous, Marc, Unité de recherches de Physiologie animale (JOUY PHYSIO A), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration
- Subjects
[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 1988
13. Le choix du sexe. La selection des spermatozoides
- Author
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Kirszenbaum, M., Cotinot, Corinne, Fellous, Marc, Unité de recherches de Physiologie animale (JOUY PHYSIO A), Institut National de la Recherche Agronomique (INRA), Laboratoire de radiobiologie et d'étude du génome (LREG), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), G. Arvis (Editeur), Unité de biologie cellulaire et moléculaire, Y. Englert, J.F. Guerin, P. Jouannet, ProdInra, Migration, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA)
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[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
chap. 18; National audience
- Published
- 1988
14. [Discussion].
- Author
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Bony S, Fellous M, Kaufmann A, Duprat S, Hilgartner S, la salle D, and Guivant J
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- Humans, Biological Science Disciplines, Democracy, Dissent and Disputes
- Published
- 2015
15. [Hermaphroditism pathology].
- Author
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Jaubert F, Nihoul-Fékété C, Lortat-Jacob S, Josso N, and Fellous M
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- Female, Gonadal Dysgenesis genetics, Humans, Male, Sex Determination Analysis, Sex Differentiation, Disorders of Sex Development pathology
- Abstract
Hermaphroditism is a general term referring to all discrepancies between phenotype and genotype of sex development. It must be preferred to sexual ambiguity which refers mainly to external genitalia anomalies. Hermaphroditism is studied on an historical and pathogenetical perspective. Short embryological summaries are integrated. The defects of sexual differentiation due to hormone deficiency are first studied: androgen insensitivity, steroid 5 alpha-reductase 2 deficiency, defects of testosterone synthesis, persistant mullerian ducts syndrome. Sexual determinism deficiencies are then presented: Turner syndrome, XX males, pure gonadal dysgenesis, true hermaphroditism, mixed gonadal dysgenesis, Drash and Frasier syndrome. Tumors of dysgenetic gonads followed. Mixed tumors developed in dysgenetic gonads are gonadoblastoma and dysgerminoma. Sex cord tumors are androgen insensitivity associated tumors, Leydig cells tumors and adrenal cell inclusion tumors. Sex reversion genes open new perspectives.
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- 2004
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16. [The genetics of sex determination].
- Author
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Vialard F and Fellous M
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- Animals, Anti-Mullerian Hormone, DAX-1 Orphan Nuclear Receptor, DNA-Binding Proteins genetics, DNA-Binding Proteins physiology, Female, Fushi Tarazu Transcription Factors, Genes, Wilms Tumor, Genes, sry, Genitalia embryology, Gonads cytology, Gonads embryology, Growth Inhibitors genetics, Growth Inhibitors physiology, High Mobility Group Proteins genetics, High Mobility Group Proteins physiology, Homeodomain Proteins, Humans, Male, Mice, Mice, Knockout, Receptors, Cytoplasmic and Nuclear, Receptors, Retinoic Acid genetics, Receptors, Retinoic Acid physiology, SOX9 Transcription Factor, Steroidogenic Factor 1, Testicular Hormones genetics, Testicular Hormones physiology, Transcription Factors genetics, Transcription Factors physiology, Glycoproteins, Repressor Proteins, Sex Determination Processes
- Abstract
The male sex determination controls the testis determination and differentiation. So far more than a dozen of gene have been characterised, including the primary Y male sex determinant: SRY gene. All the genes encode transcription factor except FDF9 which encodes a growth factor allowing mesonephritic cell to divide and migrate to the mesenchyme. All these gene products are sensitive in man (but not in the mouse model) to gene dosage: haplo-insufficiency and or duplication of these genes all lead to sex reversal. Today, we still do not know how their products are epistatic in the sex determining cascade. So far no ovary sex determining gene has been characterised.
- Published
- 2002
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