1. Prise en charge d'une colite aiguë grave.
- Author
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Laharie, David
- Subjects
- *
OLDER patients , *ULCERATIVE colitis , *CYCLOSPORINE , *DEATH rate , *EMERGENCY management , *COLECTOMY - Abstract
An acute severe flare of ulcerative colitis is observed in approximately one patient out of four with a global mortality rate of 1%. Goal of the management of this medico-surgical emergency is based on patient profile, aiming to save life of the most aged and fragile patients and to avoid salvage colectomy in the others. Medical management is standardized, based on short treatment courses starting with intravenous steroids followed by cyclosporine or infliximab in case of failure. Surgery should be discussed at each step. Postoperative morbi-mortality is closely related to the duration of the preoperative management. Drug positioning of new molecules such as védolizumab, ustekinumab and tofacitinib is not well established in acute severe ulcerative colitis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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