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Under condition of oxidative stress, free radical-catalyzed peroxidation of docosahexaenoic acid (DHA) and adrenic acid (AdA) generates in vivo neuroprostanes (NeuroPs) and dihomo-isoprostanes (dihomo-IsoPs), among a large number of key products participating in many pathophysiological processes. These non-enzymatic oxygenated metabolites display a wide range of biological actions (especially DHA-metabolites), and some of them are now considered as the most reliable indicators of oxidative stress in neurogenerative, neurodevelopmental or cardiovascular diseases. In this review, we will present an overview regarding neuroprostanes and dihomo-isoprostanes and discuss about their biological interests.

Under condition of oxidative stress, free radical mediated peroxidation of polyunsaturated fatty acids generates in vivo, cyclic metabolites like the isoprostanes, neuroprostanes, dihomo-isoprostanes, isofuranes among a large number of key products which participate in many pathophysiological processes. These metabolites display a wide range of biological actions, and some of them are now the most reliable indicators of oxidative stress in humans. In this review, we will discuss several key points of our understanding of those cyclic polyunsaturated fatty acids derivatives, going from multi-step syntheses, analytical chemistry and biological activities.

Résumé: Face aux défis planétaires de biodiversité et de changements globaux, les aires protégées (AP) sont armées pour agir dans la préservation des trois santés : humaine, animale et écosystémique. Les AP françaises jouent un rôle pivot comme sites privilégiés de la mise en pratique du concept « Une seule santé ». Les AP appliquent un modèle concret territorialisé de système socio-écologique basé sur l'interdépendance entre société humaine et nature et sur une dynamique d'échanges de biens et de services écosystémiques et anthropiques. Elles disposent d'un panel d'outils ayant pour but le maintien d'un bon équilibre global. Valorisant des exemples opérationnels de mise en pratique du concept « Une seule santé » sur le terrain, l'article fournit une boîte à outils déclinée en quatre grandes catégories d'action favorisant le bon fonctionnement des systèmes socio-écologiques. Les outils de pérennisation y sont illustrés par les réseaux sentinelles alpins. Les outils d'équilibration détaillent le rôle fondamental et certains principes de gestion de la faune sauvage. Les outils de gouvernance variés fournissent des cadres contractuels et adaptés aux territoires. Enfin, les outils d'ouverture sont présentés comme des éléments clés permettant la mise en réseau d'acteurs et la construction de solutions fondées sur la nature. Les AP sont ainsi les interfaces privilégiées d'action, directement connectées aux objectifs de développement durable de l'Agenda 2030, garantissant notamment la santé et le bien-être pour tous. Protected areas (PAs) are intended to preserve the health of humans, animals and ecosystems and to meet the global challenges of biodiversity and climate change. The key role of French PAs as preferential sites for turning the " One health " concept into practice is highlighted. PAs apply a practical territorial model of socio-ecological systems based on the interdependence between human society and nature and on an exchange of ecosystem and anthropic goods and services. They have a range of tools for maintaining good overall stability. By highlighting operational examples of applying the " One health " concept, the article provides a toolbox divided into four main categories of actions to promote the proper functioning of socio-ecological systems. Sustainability tools are illustrated by the alpine sentinel networks. The stabilization tools set forth the fundamental role of wildlife and some principles of its management. The various governance tools provide contractual frameworks adapted to the various territories. Finally, integrating tools are presented as key elements to network actors and construct nature-based solutions. PAs are thus the most appropriate interfaces for action directly linked to the sustainable development objectives of the 2030 Agenda, guaranteeing, in particular, health and well-being for all. [ABSTRACT FROM AUTHOR]

The article focuses on the work of French author Régis Jauffret. The author describes the literary world of Jauffret as complex and disconcerting. His characters are depicted as the representations of imperious and tyrannical desires. Jauffret is compared to British painter Francis Bacon, because he expresses in his writing raw desire, morbidity and obscenity. The criticism of the alienation of men by society and the detrimental effects of capitalism in the work of Jauffret are analyzed. His books "Univers, univers," "Clémence Picot" and "Autobiographie" are mentioned.

Rational: Teleconsultation (TLC) practice, which suddenly arrived in the cancer patients care, has experienced an undeniable quantitative boom given the health context. A quantitative and qualitative assessment of this practice now seems necessary. This study aims to describe the use of TLC by oncologists in the Auvergne-Rhône-Alpes region during the pandemic in order to assess its advantages and limits, and to estimate the barriers encountered and the possible levers for its promotion in oncology., Method: The use of TLC in daily medical practice was evaluated using a descriptive observational survey from October to December 2021. Health's professionals were invited to answer an online survey composed of around thirty questions., Results: Of the 200 oncologists contacted, 72 took part in the survey. Among them, 64 have already made at least one TLC. TLCs represented 25 % of consultations during the confinement period. New cancer patients, the fact of not seeing the patient physically and the absence of the possibility of carrying out a physical examination are the 3 main obstacles to TLC. The mastery of computer tools is one of the main levers. All cancer patients appear eligible for TLC ; the professionals surveyed prefer this solution for certain socio-demographic and medical characteristics of the patients (the fact of living far from the cancer centre, of having a stable clinical situation, of being under surveillance or being treated with oral anti-cancer drugs…). Despite a median level of satisfaction of 63 % estimated by doctors, less than 10 % of medical consultations are currently kept in TLC., Conclusion: TLC is now an integrated practice in oncology but seems more relevant for a specific patient profile and clinical situation. In addition, technical and training constraints still limit its use in clinical practice today., (Copyright © 2022 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)

The second plan against cancer, initiated by the French President in 2003, has introduced a two-step procedure to announce cancer to the patient. During initial visit, the doctor tells the patient about his disease. On the second visit, the doctor elaborates the treatment strategy and proposes an individualized treatment plan for each patient. The objective of this plan is to offer to patients and caregivers an accurate, precise and personalized treatment schedule. The Centre Léon Bérard (Regional Cancer Center) has implemented a computerized model to manage all different treatment schedules. We developed a software program based on two different steps. Firstly, standard treatment schedules are programmed for each type of disease. To offer a better view of the influence of treatment on daily life, we added information such as place of treatment (ambulatory, inpatient, outpatient) impact on well being (side effects, risk of aplasia...), future evaluations and medical acts (CT scan, MRI, lumbar puncture...) as well as actions the patient should take (blood cell count, to have eaten nothing...). Secondly, it tailors these standard treatments as well as all complementary information's to the specific needs of each patient, based on the medical information available in their computerized records. This personalized plan may be modified and adjusted at any time including therefore more and more real details and insights for each patient (delay of chemotherapy, dates of CT scan....). This would help patients and caregivers to better understand the different phases of the treatment and, thus, improve patient follow-up and information at every step of patient management. This tool is currently being tested at the Centre Léon Bérard.