1. New regulatory and signal functions for myristic acid
- Author
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Erwan, Beauchamp, Vincent, Rioux, Philippe, Legrand, Laboratoire de Biochimie et Nutrition Humaine, AGROCAMPUS OUEST, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
- Subjects
Fatty Acid Desaturases ,MESH: Signal Transduction ,Nitric Oxide Synthase Type III ,nitric-oxide synthase ,MESH: Cell Physiological Phenomena ,dependent manner ,Virus Replication ,Myristic Acid ,Cell Physiological Phenomena ,protein n-myristoyltransferase ,palmitic acid ,Humans ,cultured rat hepatocytes ,increases ,immunodeficiency-virus type-1 ,MESH: Humans ,MESH: Virus Replication ,Membrane Proteins ,MESH: Fatty Acid Desaturases ,coa ,fatty-acids ,Dietary Fats ,Lipids ,terminal myristoylation ,MESH: Lipids ,[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] ,MESH: Dietary Fats ,MESH: Myristic Acid ,lipids (amino acids, peptides, and proteins) ,MESH: Nitric Oxide Synthase ,Endothelium, Vascular ,MESH: Endothelium, Vascular ,MESH: Membrane Proteins ,Nitric Oxide Synthase ,MESH: Nitric Oxide Synthase Type III ,Signal Transduction - Abstract
Myristic acid is a 14 carbon saturated fatty acid, which is mostly found in milk fat. In industrialized countries, its excessive consumption is correlated with an increase in plasma cholesterol and mortality due to cardiovascular diseases. Nevertheless, one feature of this fatty acid is its ability to acylate proteins, a reaction which is called N-terminal myristoylation. This article describes various examples of important cellular regulations where the intervention of myristic acid is proven. Modulations of the cellular concentration of this fatty acid and its associated myristoylation function might be used as regulators of these metabolic pathways.
- Published
- 2009