50 results on '"De, S"'
Search Results
2. Shareholder invisível: uma perspectiva teórica da relação entre capital natural, negócios e sociedade
- Author
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Rayla dos Santos Oliveira Dias and Aracéli Cristina de S. Ferreira
- Subjects
Capital natural ,Negócios ,Sociedade ,Contabilidade ,Shareholder invisível ,Business ,HF5001-6182 - Abstract
Resumo O termo “capital natural” teve sua origem atrelada à Economia; nos últimos anos, no entanto, discussões a seu respeito têm crescido na área de Contabilidade. Definido como o estoque de recursos naturais renováveis ou não renováveis, que se combinam para produzir um fluxo de benefícios para a sociedade e para os negócios, o capital natural fornece valor por meio dos seus serviços ecossistêmicos. Nesse caso, considerando que: o capital natural é derivado de recursos naturais que compõem o patrimônio natural, a combinação desses recursos contribui para que os negócios criem valor, e a participação da sociedade no valor gerado pelos negócios não é evidenciada pela contabilidade, o presente ensaio tem por objetivo propor a perspectiva teórica do shareholder invisível, tendo em vista a contribuição ainda não reconhecida da sociedade como fornecedora do capital natural aos negócios. Para tal, o estudo apresenta a relação entre o capital natural, os negócios e a sociedade, com base: nos aspectos associados a propriedade e controle, na contribuição do capital natural no processo de criação de valor dos negócios e nos elementos que envolvem a evidenciação dessa relação na contabilidade.
- Published
- 2023
- Full Text
- View/download PDF
3. Trajetória Sinuosa: Surgimento de uma Dimensão Pública na Formulação da Política de Defesa no Brasil?
- Author
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Rubens de S. Duarte
- Subjects
política de defesa ,política pública ,relações civis-militares ,Democracia ,Segurança ,Social sciences (General) ,H1-99 - Abstract
RESUMO Por meio de um esforço de monitoramento empírico, este artigo tem como objetivo analisar de que modo mecanismos institucionais do Estado brasileiro e recentes movimentos na sociedade afetam a trajetória de construção de uma dimensão pública mais plural no processo de formulação da política de defesa no Brasil. A caracterização da política de defesa como uma política pública sui generis sugere a pertinência de investigar o jogo político entre atores assimétricos que permeiam as tomadas de decisão. Por meio de análises da literatura acadêmica, de relatórios oficiais, do ordenamento jurídico e de entrevistas, este artigo argumenta que houve avanços na construção de uma dimensão pública para a defesa, embora a falta de institucionalidade e a baixa qualidade do diálogo façam que essa trajetória seja frágil e não linear.
- Published
- 2022
- Full Text
- View/download PDF
4. DOSSIÊ: PESCA ARTESANAL: PRÁTICAS SOCIAIS, TERRITÓRIO E CONFLITOS
- Author
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Francisca de S. Miller, Ellen Fensterseifer Woortmann, Letícia D’Ambrosio Camarero, José Manuel Sobral, and José Colaço Dias Neto
- Subjects
Anthropology ,GN1-890 ,Sociology (General) ,HM401-1281 - Published
- 2020
- Full Text
- View/download PDF
5. Indicadores epistemológicos do 'Brazil-Medico': Educação e Educação Física
- Author
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Maria Isabel Brandão de S. Mendes and Terezinha Petrucia da Nóbrega
- Subjects
saúde ,Educação Física ,corpo ,Theory and practice of education ,LB5-3640 - Abstract
O artigo evidencia relações entre a Educação escolar e a Educação Física com base em indicadores epistemológicos relacionados aos cuidados com o corpo em busca de saúde, presentes no final do século XIX e início do XX. O material empírico utilizado foi o periódico "Brazil-Medico", do período de 1887-1923. Este estudo tece reflexões sobre cuidados com a saúde na Educação e aponta elementos sobre a sistematização da Educação Física, tendo como foco o método racional. Conclui-se que a Educação Física contribuiu com a interiorização de cuidados com o corpo em busca de saúde na Educação escolar, chamando a atenção para a vivacidade das crianças. A sistematização da Educação Física através do método racional contribuiu com o reconhecimento da existência da cultura física, das expressões do corpo, numa época em que prevalecia um ensino pautado na memorização e na imobilidade.
- Published
- 2015
- Full Text
- View/download PDF
6. Limitations of a dynamic shear-frame model based in a small-scale experimental steel structure
- Author
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de S. Pippi Augusto, Bernardes Júnior Pedro L., Avila Suzana M., de Morais Marcus V. G., and Doz Graciela
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Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Many engineering problems require geometric modeling and mechanical simulation of structures. Through the structural models, engineers try to simulate the real behavior of these structures. It is important that a model contain all the necessary parameters that describe the structure and its behavior during its useful life. In the field of dynamics, one of the most used models is the shear-frame, in which the stiffness of the structure is given by the stiffness of the columns and the whole mass is concentrated in the floor levels, which are considered with infinite stiffness. In some cases, this simplification offers more conservative results, which can lead to considerable errors, especially in the case of natural frequencies. Knowing that the quality of a structural model depends on the simplifications considered, an experimental 3D steel frame, constructed to typify the dynamic behavior of a tall building, was tested with a data acquisition system and accelerometers, in order to obtain its natural frequencies. In addition, a numerical model was developed in order to ascertain the results. These values of natural frequencies are compared with an idealized shear-frame model obtained from the experimental model. This comparison allows a critical analysis of the numerical models that can be employed to represent the real dynamic behavior of structures. The aim of the investigation is to show the results of the modal analysis for each model, comparing them with the experimental results and commenting their advantages and the limitations.
- Published
- 2018
- Full Text
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7. Metodologia Geolinguística: o Atlas Linguístico do Paraná
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Rosa Evangelina de S. Belli Rodrigues
- Subjects
metodologia ,Language and Literature ,Philology. Linguistics ,P1-1091 - Abstract
Este trabalho tem por objetivo analisar a metodologia e descrever os resultados do Atlas Lingüístico do Paraná – ALPR (AGUILERA, 1990), localizando-o em relação aos outros atlas brasileiros. Para levar a cabo este intento, apresentamos, inicialmente, as modificações, principalmente metodológicas, sofridas pela geolinguística rumo à descrição cada vez mais completa e profunda da variação linguística. São apresentados o modelo geolinguístico pluridimensional e contatual de Harald Thun (1998) e o Atlas Linguístico do Brasil – ALiB (CARDOSO et al., 2014), publicado em outubro de 2014. Fez-se também necessário descrever, ainda que brevemente, o método mais tradicional de pesquisa geolinguística, característico do ALPR, para depois voltar o texto propriamente para o atlas de Aguilera. Após discutir os critérios com que o ALPR foi construído, desde a escolha dos informantes até o tipo de cartas geolinguísticas que o compõem, bem como sua complementação pelo ALPR II (ALTINO, 2007), foi possível analisar seus resultados, relacionando-os com as hipóteses de trabalho da tese que lhe deu origem
- Published
- 2015
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8. O Congresso Brasileiro e a distribuição de benefícios sociais no período 1988-1994: uma análise distributivista
- Author
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Lemos Leany Barreiro de S.
- Subjects
Brazilian Legislature ,distributist behavior ,legislative action ,social policies ,Executive-Legislative relations ,Social sciences (General) ,H1-99 - Abstract
This study is about the behavior of Brazilian Congress members, concerning education and health bills from 1988 to 1994. A 817-bills database was built in order to test three hypotheses: whether members of Congress tended to "concentrate" resources as opposed to "spreading" them, a rejected hypothesis; whether there was a connection between "resource-concentrating" action and ideological spectrum; region, both confirmed. The paper also highlights that most bills tended to be submitted in the early years of member's term; who would be the main beneficiaries of the bills, presenting a link political parties-benefited groups; and the low approval capacity of Brazilian Legislative, while a high veto activity from the Executive body.
- Published
- 2001
9. Unconfined strength of an unsaturated residual soil struck lightning
- Author
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Carnavale Thiago de S., Motta Mariana F.B., de Campos Tácio. M.P., Alves Haimon D.L., de Oliveira Antônio R.M.B., and Martins Hélvio J.A.
- Subjects
Environmental sciences ,GE1-350 - Abstract
It is well known that different triggering factors are related to landslides occurrence. However, in many cases, it is not possible to identify main factors that may contribute to start a landslide. Following that, lightning phenomena is herein considered as a possible factor that may promote changes in the structure, and eventually, in the strength of soils. The current study aims to analyse the influence of laboratory simulated lightning in the structure of undisturbed granite-gneiss residual soil samples. The main focus is to compare the peak strength of unsaturated samples that were not struck by replicated lightning with the peak strength of soil samples struck by replicated lightning. The methods used are: Soil sampling and physical characterization; unconfined compression strength tests on unsaturated undisturbed samples; submission of soil samples to replicated lightning; unconfined compression strength tests on samples struck by replicated lightning and micro tomography of samples submitted to lightning. As results, it is seem that lightning may cause a hole with irregular geometry inside the soil. Analysing the tests of the samples struck by laboratory simulated lightning, a peak strength reduction with the charge incidence was observed. Comparing the variation of soil matric suction on the peak strength of the soil that was not struck by replicated lightning with that of the soil struck by the higher charge of the replicated lightning, it is observed that the samples struck by high-voltage presents lower values of peak strength.
- Published
- 2016
- Full Text
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10. Vins tropicaux de la région semi-aride du Brésil
- Author
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PEREIRA, G. E., GUERRA, C. C., AMORIM, F. M. de, NASCIMENTO, A. M. DE S., SOUZA, J. F. DE, LIMA, L. L. DE A., LIMA, M. DOS S., PADILHA, C. V. S., PROTAS, J. F. da S., ZANUS, M. C., TONIETTO, J., GIULIANO ELIAS PEREIRA, CNPUV, CELITO CRIVELLARO GUERRA, CNPUV, FRANCISCO MACEDO DE AMORIM, Instituto Federal do Sertão Pernambucano, ANTONIO MENDES DE SOUZA NASCIMENTO, Universidade do Estado da Bahia, JOYCE FAGUNDES DE SOUZA, Universidade do Estado da Bahia, LUCIANA LEITE DE ANDRADE LIMA, Universidade Federal Rural de Pernambuco-UFRPE, MARCOS DOS SANTOS LIMA, Instituto Federal do Sertão Pernambucano, CARLA VALÉRIA DA SILVA PADILHA, Instituto Federal do Sertão Pernambucano, JOSE FERNANDO DA SILVA PROTAS, CNPUV, MAURO CELSO ZANUS, CNPUV, and JORGE TONIETTO, CNPUV.
- Subjects
Grapes ,Pernambuco ,São Francisco Valley ,Bahia ,Typicité ,Raisin ,Vale do São Francisco ,Vins tropicaux ,Qualité ,Quality ,Tropical wines ,Typicality - Abstract
Les vins tropicaux sont ceux produits dans les régions vitivinicoles où plusieurs cycles végétatifs de la vigne peuvent se produire par an, avec au moins une récolte annuelle. Les principaux facteurs qui contribuent à cette vitiviniculture en basses latitudes sont : des températures élevées tout au long de l'année, des précipitations modérées ou insuffisantes, un rayonnement solaire abondant et de l'eau disponible pour l'irrigation. Des cycles continus peuvent se produire, et c'est alors le producteur qui décide quand tailler et quand récolter, selon les saisons des pluies, les demandes du marché, la structure physique et les types de vins produits. Les vins tropicaux sont produits dans le Vale do São Francisco, au nord-est du Brésil, depuis plus de trente ans. La vitiviniculture pratiquée dans la région est l'une des plus technicisées au monde, car elle exige un haut degré de connaissances de la part des viticulteurs et des techniciens, en termes de manipulation du terrain, ainsi que des connaissances différentes des ?nologues lors de la vinification. La région produit des vins effervescents de muscat, des vins effervescents traditionnels secs et demi-sec, des vins rouges encore jeunes et de garde, et des vins blancs jeunes, en plus des vins communs (de table), plus récemment. Cet article présente les caractéristiques de cette vitiviniculture jeune et différenciée, par rapport à celle pratiquée dans les pays producteurs traditionnels, ainsi que les résultats des recherches menées dans la région au cours des quinze dernières années, en partenariat avec les domaines viticoles. Made available in DSpace on 2020-12-19T09:03:18Z (GMT). No. of bitstreams: 1 Vins-tropicaux-de-la-region-semi-aride-du-Bresil.pdf: 2113140 bytes, checksum: 7964eafb4d725d59ab22ce3e79200bb0 (MD5) Previous issue date: 2020
- Published
- 2020
11. Construção da ordem temporal na gênese da comunicação narrativa em Meus verdes anos
- Author
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Maria Lúcia de S. Agra
- Subjects
Philology. Linguistics ,P1-1091 ,Literature (General) ,PN1-6790 - Abstract
Este texto apresenta um estudo sobre a construção do tempo durante o processo genético da comunicação narrativa no prototexto de Meus verdes anos, de José Lins do Rego. A análise dos procedimentos de construção estrutural do discurso mostra que, ao desvendar os movimentos escriturais, a crítica genética contribui com os trabalhos da teoria literária.
- Published
- 2012
12. La construction du corps par le bodybuilding au Brésil
- Author
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Mendes B. de S. , Isabel, Alves Franco, Marcel, and Ohl, Fabien
- Subjects
Corps Dopage Bodybuilding - Abstract
Cet article a comme objectif comprendre la construction du corps par le bodybuilding. Il s’agit d’une étude de terrain qui a permis d’interviewer des bodybuilders du nord-est du Brésil. Des entretiens de type semi-structuré ont été réalisés avec un échantillon de huit hommes et deux femmes. Nous avons procédé à une analyse de contenu des entretiens. Les résultats ont permis d’identifier des usages différenciés du bodybuilding en lien avec les expériences passées du corps, les modes d’engagement et le sexe. Si la souffrance évoquée pour expliquer son engagement dans la pratique est individuelle, l’adhésion à de nouvelles normes de construction du corps se fait par un collectif de personnes qui conduisent à normaliser la consommation de substances pharmacologiques.
- Published
- 2019
13. O Protonarrador
- Author
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Maria Lucia de S. Agra
- Subjects
Philology. Linguistics ,P1-1091 ,Literature (General) ,PN1-6790 - Abstract
O objetivo deste estudo é desenvolver um texto teórico sobre o processo narrativo, tendo em vista a definição e a caracterização do narrador em construção, além da verificação de suas funções.
- Published
- 1992
14. Agent Based Models and Complex Individuals: An Epistemological Analysis
- Author
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Solange Regina Marin, Brena Paula M. Fernande, and Daniel de S. Vasconcelos
- Subjects
agent-based modeling ,epistemology ,situational analysis ,Popper (Karl R.) ,circular cumulative causation ,Myrdal (Gunnar) ,Social Sciences - Abstract
In the relevant literature concerning Agent Based Models (ABMs), there seems to be agreement that they may replace the rational agent model of neoclassical economics. The question is whether this new, realistic, and complex model requires an equally complex concept of the individual. We propose the application of three major concepts in the epistemology of social sciences to advance the discussion of the concept of the complex individual, namely: i) Popper’s situational analysis; ii) Simon’s bounded rationality; and iii) Myrdal’s concept of circular cumulative causation. We argument that these are promising starting points for an analysis of human behavior, complex individuals and ABMs.
- Published
- 2001
15. Écologie du savoir proportionnalité : un regard sur les références curriculaires.
- Author
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Melo Vieira, Maria Sônia L., Barros, Alexandre Luís De S., and Câmara Dos Santos, Marcelo
- Subjects
- *
PROPORTIONALITY (Ethics) , *ECOLOGY , *HIGH schools , *ELEMENTARY schools , *EDUCATIONAL anthropology - Abstract
This work aims to study the ecology of the knowledge proportionality on the curricular references from the state of Pernambuco (Brazil), in elementary school and in high school. Qualitative research of documents, which allows for the analyses of the institutional approach to the knowledge proportionality under the Anthropologic Theory of Didatics. Therefore, we have identified the existence of an institutional approach between the knowledge proportionality and the reference analyzed. We have found different places that constitute the habitats of this knowledge and have identified its activities on different niches. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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16. LE JEUNE DE 1681
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de S., F.
- Published
- 1881
17. Ceylan 1957
- Author
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de S. INDRARATNA, A. D. V.
- Published
- 1958
18. Fluctuations économiques dans l'île de Ceylan
- Author
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de S. INDRARATNA, A. D. V.
- Published
- 1959
19. Antoine de Montchrestien était-il catholique ou protestant?
- Author
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de S., B.
- Published
- 1894
20. Cooperação internacional e desenvolvimento: análise da atuação de agências internacionais em Duque de Caxias (Rio de Janeiro)
- Author
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Carlos R. S. Milani and Julio Cesar de S. Loureiro
- Subjects
International cooperation ,International agencies ,Development ,Duque de Caxias (Rio de Janeiro) ,Critical analysis ,Business ,HF5001-6182 - Abstract
Considerando a cooperação internacional para o desenvolvimento (CID) como campo político cujas bases filosóficas - a crença no progresso, a esperança como tarefa política ou imperativo, o desenvolvimento como meta - alimentam relações de assimetria, hierarquia e dependência, são apresentados e discutidos, neste artigo, os resultados de uma pesquisa empírica realizada em Duque de Caxias (região metropolitana do Rio de Janeiro) entre setembro de 2010 e janeiro de 2012, a fim de responder a duas perguntas principais: 1) o que revelam as práticas das agências internacionais atuantes no desenvolvimento local de Duque de Caxias? 2) o que o contexto local desse município da região metropolitana do Rio de Janeiro ilustra acerca das tendências analisadas pela literatura mais crítica sobre o papel da cooperação para o desenvolvimento? Valendo-se de autores críticos sobre o papel político das organizações da CID - B. Cooke, W. Easterley, A. Escobar, T. Hayter, G. Rist, entre outros - e, da pesquisa, de natureza qualitativa, é descrito e analisado o modo de atuação das agências internacionais, sejam elas governamentais multilaterais ou bilaterais, empresas privadas, organizações filantrópicas ou associações, na definição e implementação de estratégias de desenvolvimento em Duque de Caxias. Conclui-se que as organizações internacionais raramente atuam no plano municipal de Duque de Caxias, limitando-se a agir mais indiretamente na concepção de projetos pontuais de apoio ao desenvolvimento e exercendo seu poder de influência sobre as agendas de políticas públicas de âmbito local.
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21. Les secheresses de la region Nordeste du Bresil et leurs consequences
- Author
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LEPRUN, J. C., MOLINIER, M., CADIER, E., FOTIUS, G., GALINDO, O., RAMOS, F. de S., SOUZA, H. R. de, JEAN-ClAUDE LEPRUN, ORSTOM, MICHEL MOLlNIER, Consultor CPATSA/ORSTOM, ÉRIC CADIER, GEORGES FOTIUS, Consultor CPATSA/ORSTOM, OSMIL GALlNDO, Fundação Joaquim Nabuco, FRANCISCO DE SOUZA RAMOS, UFPE, and HERMINíO RAMOS DE SOUZA, UFPE.
- Subjects
Seca ,Nordeste ,Consequencia ,Hidrologia ,Hidrology ,Northeast ,Clima ,drought ,Consequence ,climate - Abstract
Le Nordeste bresilien est une region qui a constamment ete affectee par la secheress. La premiere a etre repertoriee historiquement fut celle de 1499-1500 et, depuis le debut de ce siecle, on denombre vingt-sept annees seches soit, en moyenne, une annee sur trois a quatre. La terrible secheresse de 1877-1879 aurait fait 500.000 victimes parmi les habitants du Ceare et des Etats voisins, dont 119.000 a Fortaleza. EN fait, comme on le verra plus loin, la notion de secheresse est complexe et s'exerce sur toute la zone semi-aride du "polygone des secheresses" qui occupe une superficie de pres de 1 million de km2 et regroupe environ 65% de la populatoin du Nordeste. Pour cette population, qui compte 17 millions de ruraux pratiquant une agriculture de subsistance vulnerable, toute annee a alimentation des reserves d'eau et/ou a production agricole deficitaires est une annee seche supplementaire difficile qu'il faut surmonter pour survivre. Ces secheresses periodiques perturbent le fonctionnement de l'ecosysteme et ont des repercussions economiques, sociales et politiques importantes. Made available in DSpace on 2018-08-09T00:30:07Z (GMT). No. of bitstreams: 1 Secheressev.6n.1p.23331995.pdf: 11389261 bytes, checksum: bbd1b128af442fbfb4d61d50a32c6547 (MD5) Previous issue date: 1996-07-17
- Published
- 1995
22. "Représentations sociales et embryon humain : une étude comparative Brésil/France.".
- Author
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S. Alessio, Renata L. Dos, Apostolidis, Thémistoklis, De S. Santos, Maria de Fátima, and Dany, Lionel
- Abstract
Copyright of Cahiers Internationaux de Psychologie Sociale is the property of Presses Universitaires de Liege and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2011
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- View/download PDF
23. The Neolithic Cultures of the British Isles, (Library Editions) Stuart Piggott
- Author
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de S.-M., S.
- Published
- 1973
24. Où naquit Francisco de Vitoria, O.P. ?
- Author
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Bruno de S. Joseph
- Subjects
Earth-Surface Processes - Abstract
de S. Joseph Bruno. Où naquit Francisco de Vitoria, O.P. ?. In: Revue néo-scolastique de philosophie. 34ᵉ année, Deuxième série, n°34, 1932. pp. 247-249.
- Published
- 1932
25. [Bilateral polycystic ovaries. A histological study of surgical biopsies done without selection of cases]
- Author
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Y, Procopio-Valle, W A, Chagas, D, de Paola, A de S, Matsui, and C G, de Andrade
- Subjects
Adult ,Diagnosis, Differential ,Ovary ,Humans ,Female ,Ovarian Diseases ,Middle Aged ,Aged ,Polycystic Ovary Syndrome - Published
- 1967
26. La carte des Jésuites
- Author
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Marie de S-Jean d’Ars
- Subjects
History
27. Study of magnetoaerodynamic phenomena
- Author
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de, S
- Published
- 2020
28. Héliodore et le genre romanesque
- Author
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Kasprzyk, Dimitri, Héritages et Constructions dans le Texte et l'Image (HCTI), Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO)-Université de Brest (UBO)-Université de Bretagne Sud (UBS)-Université de Brest (UBO), sur l'invitation de S. van der Meeren, and Flood, Noemie
- Subjects
[SHS] Humanities and Social Sciences ,ComputingMilieux_MISCELLANEOUS ,[SHS]Humanities and Social Sciences - Abstract
International audience
- Published
- 2017
29. Cils et morphogenèse cardiaque
- Author
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Diguet, Nicolas, Meilhac, Sigolène, Département de Biologie du Développement et Cellules souches - Department of Developmental and Stem Cell Biology, Institut Pasteur [Paris], Centre National de la Recherche Scientifique (CNRS), Les travaux de l’équipe de S. Meilhac sont financés par la Fondation pour la recherche médicale, l’Agence nationale pour la recherche et l’Institut national de la santé et de la recherche médicale., Institut Pasteur [Paris] (IP), Bases Génétiques, Moléculaires et Cellulaires du Développement (BGMCD), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[SDV.BDD]Life Sciences [q-bio]/Development Biology - Abstract
International audience; After the seminal discovery in 2000 that primary cilia are functional organelles which are essential for embryonic development, several mouse models of ciliopathies have been generated. The heart is frequently affected, with a large spectrum of malformations. The cilia of the node are required early in development in the determination of the left/right laterality of the embryo, which has secondary consequences on the formation of the heart. Thus, abnormal looping of the heart is a recurrent phenotype in models of ciliopathies. However, the function of primary cilia in cardiac cells remains poorly understood. Receptors such as polycystins or hedgehog receptors are usually localized in the primary cilium, raising the possibility that these signalling pathways, which are important for the septation and the growth of the heart, are transduced in primary cilia of cardiac cells. Knowledge of the roles of primary cilia at different steps of heart development and in different cardiac cell types will be essential to better understand the origin of human cardiopathies associated with ciliopathies.; Après la mise en évidence fondamentale en 2000 des cils primaires comme organites fonctionnels et essentiels au développement embryonnaire, de nombreux modèles murins de ciliopathies ont été générés. Dans ces modèles, le cœur est fréquemment affecté, avec un large spectre de malformations. Les cils du nœud sont requis à un stade précoce du développement pour la détermination de la latéralité droite/gauche de l’embryon, avec des conséquences secondaires sur la formation du cœur. Ainsi, une courbure anormale du cœur est un phénotype récurrent dans les modèles de ciliopathies. Cependant, la fonction des cils primaires dans les cellules cardiaques reste mal comprise. Des récepteurs, tels que les polycystines ou les récepteurs de la voie Hedgehog, sont habituellement localisés dans les cils primaires. Ceci permet d’envisager la possibilité que la transduction de ces voies de signalisation, qui sont importantes pour le cloisonnement et la croissance du cœur, ait lieu dans les cils primaires de cellules cardiaques. La connaissance du rôle des cils primaires à plusieurs étapes de la formation du cœur, et dans différents types cellulaires cardiaques, est essentielle pour comprendre l’origine des cardiopathies humaines associées à des ciliopathies.
- Published
- 2014
30. Cilia and heart morphogenesis
- Author
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Nicolas Diguet, Sigolène M. Meilhac, Département de Biologie du Développement et Cellules souches - Department of Developmental and Stem Cell Biology, Institut Pasteur [Paris], Centre National de la Recherche Scientifique (CNRS), and Les travaux de l’équipe de S. Meilhac sont financés par la Fondation pour la recherche médicale, l’Agence nationale pour la recherche et l’Institut national de la santé et de la recherche médicale.
- Subjects
Patched Receptors ,0303 health sciences ,Heart development ,Cilium ,Morphogenesis ,General Medicine ,Biology ,Ciliopathies ,Phenotype ,General Biochemistry, Genetics and Molecular Biology ,Cell biology ,03 medical and health sciences ,0302 clinical medicine ,Ciliary Motility Disorders ,Hedgehog ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
International audience; After the seminal discovery in 2000 that primary cilia are functional organelles which are essential for embryonic development, several mouse models of ciliopathies have been generated. The heart is frequently affected, with a large spectrum of malformations. The cilia of the node are required early in development in the determination of the left/right laterality of the embryo, which has secondary consequences on the formation of the heart. Thus, abnormal looping of the heart is a recurrent phenotype in models of ciliopathies. However, the function of primary cilia in cardiac cells remains poorly understood. Receptors such as polycystins or hedgehog receptors are usually localized in the primary cilium, raising the possibility that these signalling pathways, which are important for the septation and the growth of the heart, are transduced in primary cilia of cardiac cells. Knowledge of the roles of primary cilia at different steps of heart development and in different cardiac cell types will be essential to better understand the origin of human cardiopathies associated with ciliopathies.; Après la mise en évidence fondamentale en 2000 des cils primaires comme organites fonctionnels et essentiels au développement embryonnaire, de nombreux modèles murins de ciliopathies ont été générés. Dans ces modèles, le cœur est fréquemment affecté, avec un large spectre de malformations. Les cils du nœud sont requis à un stade précoce du développement pour la détermination de la latéralité droite/gauche de l’embryon, avec des conséquences secondaires sur la formation du cœur. Ainsi, une courbure anormale du cœur est un phénotype récurrent dans les modèles de ciliopathies. Cependant, la fonction des cils primaires dans les cellules cardiaques reste mal comprise. Des récepteurs, tels que les polycystines ou les récepteurs de la voie Hedgehog, sont habituellement localisés dans les cils primaires. Ceci permet d’envisager la possibilité que la transduction de ces voies de signalisation, qui sont importantes pour le cloisonnement et la croissance du cœur, ait lieu dans les cils primaires de cellules cardiaques. La connaissance du rôle des cils primaires à plusieurs étapes de la formation du cœur, et dans différents types cellulaires cardiaques, est essentielle pour comprendre l’origine des cardiopathies humaines associées à des ciliopathies.
- Published
- 2014
31. Comparaison de l'impact de techniques de diagnostic des connaissances sur l'apprentissage d'une stratégie d'aide
- Author
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Lallé, Sébastien, Mostow, Jack, Luengo, Vanda, Guin, Nathalie, Supporting Interaction and Learning by Experience (SILEX), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Université Lumière - Lyon 2 (UL2), Laboratoire d'Informatique de Grenoble (LIG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), The Robotics Institute, Carnegie Mellon University [Pittsburgh] (CMU), MeTAH, Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Bourse de thèse et mobilité de S. Lallé: Région Rhône-Alpes (France) et Institute of Education Sciences (U.S): subvention R305A080628 accordée à l'université Carnegie Mellon, and Lefevre, Marie
- Subjects
[INFO.INFO-AI] Computer Science [cs]/Artificial Intelligence [cs.AI] ,[INFO.EIAH] Computer Science [cs]/Technology for Human Learning ,[SHS.EDU]Humanities and Social Sciences/Education ,[SHS.EDU] Humanities and Social Sciences/Education ,prédiction ,[INFO.EIAH]Computer Science [cs]/Technology for Human Learning ,Technique de diagnostic ,classification automatique ,aide ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] - Abstract
Session : Utilisation de techniques d'apprentissage automatique en EIAH - http://www.irit.fr/EIAH2013/index.php?page=programme; National audience; Nous décrivons une méthode pour comparer des techniques de diagnostic des connaissances en fonction de leur impact sur les prises de décision de l'EIAH. À partir de traces d'apprenants, nous utilisons une méthode de classification automatique pour prédire le résultat (succès ou échec) d'une aide donnée par l'EIAH, en prenant en considération des informations sur l'apprenant, la tâche et l'état des connaissances de l'apprenant. Il en résulte une stratégie d'aide apprise automatiquement et permettant de sélectionner dans une situation donnée l'aide ayant la probabilité la plus élevée de succès. Le moyen usuel mais coûteux d'évaluer une telle stratégie d'aide est de l'implémenter et de la tester sur de nouveaux apprenants, ce qui nécessite du temps et des moyens. Nous utilisons plutôt des données déjà collectées, où les aides sont données aléatoirement aux apprenants, pour simuler l'impact d'une stratégie d'aide. Nous comparons ensuite différentes stratégies d'aide basées sur différentes techniques de diagnostic. Nous avons testé notre méthode en utilisant les données du Reading Tutor (projet LISTEN), destiné à l'apprentissage de la lecture. Nous rapportons la précision de la prédiction de quatre techniques de diagnostic en validation croisée, puis comparons l'impact des stratégies d'aide basées sur ces techniques. Notre méthode fournit une métrique pour comparer différentes techniques de diagnostic fondées sur leur utilité pour les prises de décision de l'EIAH.
- Published
- 2013
32. La pratique de l'agglutination des érythrocytes et du test de Coombs: Rouger, P. & Salmon, C. (coll. ⪡ Techniques de laboratoire ⪢ 6). 1 vol. (13,5 × 21 cm), 99 pages. Masson, Paris, New York, Barcelone, Milan, Mexico, Rio de Janeiro, 1981
- Author
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de S.-M., J.
- Published
- 1981
- Full Text
- View/download PDF
33. Nouvelle methode pour apprendre facilement les principes et la pureté de la langue françoise, Paris, P. Baudouin, 1662 (1re éd. 1656)
- Author
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Irson, Claude, Leclercq, Odile, Delesalle, Simone, Mazière, Francine, HTL - Histoire des Théories Linguistiques - UMR 7597 (HTL), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Nouvelle - Paris 3, Edition scientifique électronique de Odile Leclercq, avec la collaboration de S. Delesalle et F. Mazière, Université Sorbonne Nouvelle - Paris 3-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), and Lazcano, Elisabeth
- Subjects
Histoire de la linguistique ,[SHS.LANGUE]Humanities and Social Sciences/Linguistics ,[SHS.LANGUE] Humanities and Social Sciences/Linguistics - Published
- 2011
34. Essay d'une parfaite Grammaire de la langue françoise Ou le Lecteur trouurera, en bel ordre, tout ce qui est de plus necessaire, de plus curieux, et de plus elegant, en la Pureté, en l'Orthographe, et en la Prononciation de cette Langue. Anvers 1659 (1re éd. 1659)
- Author
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Chiflet, R. P. Laurent, Baddeley, Suzan, Colombat, Bernard, Leclercq, Odile, Mazière, Francine, Raby, Valérie, Laboratoire de Médiévistique Occidentale de Paris (LAMOP), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), HTL - Histoire des Théories Linguistiques - UMR 7597 (HTL), Université Sorbonne Nouvelle - Paris 3-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Edition scientifique électronique de S. Baddeley, B. Colombat, O. Leclercq, F. Mazière et V. Raby, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Nouvelle - Paris 3, and Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Histoire de la linguistique ,[SHS.LANGUE]Humanities and Social Sciences/Linguistics - Published
- 2011
35. Les règles de conflit spéciales en matière de délits dans le Règlement du 11 juillet 2007 (Rome II)
- Author
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Joubert , Natalie, Malicet, Marianne, Credimi, sous la direction de S. Corneloup et N. Joubert, Centre de recherche sur le droit des marchés et des investissements internationaux [Dijon] ( CREDIMI ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Bourgogne ( UB ), Centre de recherche sur le droit des marchés et des investissements internationaux [Dijon] (CREDIMI), and Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[SHS.DROIT]Humanities and Social Sciences/Law ,[SHS.DROIT] Humanities and Social Sciences/Law ,Rome II ,[ SHS.DROIT ] Humanities and Social Sciences/Law ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2008
36. La responsabilité du fait des produits
- Author
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Corneloup , Sabine, Centre de recherche sur le droit des marchés et des investissements internationaux [Dijon] ( CREDIMI ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Bourgogne ( UB ), Credimi, sous la direction de S. Corneloup et N. Joubert, Centre de recherche sur le droit des marchés et des investissements internationaux [Dijon] (CREDIMI), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), and Malicet, Marianne
- Subjects
[SHS.DROIT]Humanities and Social Sciences/Law ,[SHS.DROIT] Humanities and Social Sciences/Law ,Rome II ,ComputingMilieux_MISCELLANEOUS ,[ SHS.DROIT ] Humanities and Social Sciences/Law - Abstract
International audience
- Published
- 2007
37. Réalités et limites de l'entraide familiale
- Author
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Déchaux, Jean-Hugues, Déchaux, Jean-Hugues, Sous la direction de S. Paugam, MOndes et DYnamiques des Sociétés (MODYS), and Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Lumière - Lyon 2 (UL2)
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inégalités sociales ,[SHS.SOCIO]Humanities and Social Sciences/Sociology ,Etat-providence ,[SHS.SOCIO] Humanities and Social Sciences/Sociology ,Entraide familiale ,parenté - Published
- 2007
38. ' Le roman indien du phénix ou les variations romanesques du mythe du phénix '
- Author
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Lecocq, Françoise, Centre Michel de Boüard - Centre de recherches archéologiques et historiques anciennes et médiévales ( CRAHAM ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ), R. Poignault (éd.), avec la collaboration de S. Dubel, Centre Michel de Boüard - Centre de recherches archéologiques et historiques anciennes et médiévales (CRAHAM), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), and Leroy-Hale, Marie-Noëlle
- Subjects
[ SHS.HIST ] Humanities and Social Sciences/History ,[SHS.HIST] Humanities and Social Sciences/History ,[SHS.HIST]Humanities and Social Sciences/History ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2006
39. Compensation de déformations en tomographie dynamique 3D conique
- Author
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Desbat, Laurent, Roux, Sébastien, Grangeat, Pierre, Gestes Medico-chirurgicaux Assistés par Ordinateur (TIMC-IMAG-GMCAO), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), GMCAO, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Ce travail a bénéficié en partie de soutiens du CNRS et du CEA (bourse BDI de S. Roux) et du projet CIMENT (http ://ciment.ujf-grenoble.fr/). Laurent Desbat remercie l'ACI GRID (projet CIMENT GRID), la Région Rhône Alpes (projet RAGTIME) et l'ANR (projet ToRIID) pour leur soutien., Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), and Desbat, Laurent
- Subjects
dynamic ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Physics::Medical Physics ,cone beam ,Physics::Accelerator Physics ,Tomography - Abstract
19 pages; In dynamic tomography, the measured object or organs are no-longer supposed to be static in the scanner during the acquisition but are supposed to move or to be deformed. Our approach is the analytic deformation compensation during the reconstruction. Our work concentrates on 3D cone beam tomography. We introduce a new large class of deformations preserving the 3D cone beam geometry. We show that deformations from this class can be analytically compensated. We present numerical experiments on phantoms showing the compensation of these deformations in 3D cone beam tomography.
- Published
- 2006
40. Dépistage des hépatites au sein d’une association culturelle et cultuelle pakistanaise : retour d’expérience.
- Author
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Paternoster M, Badoro B, Bourovali-Zade C, Castera C, Cordel H, Monteynard S, Hocde C, Jaroof S, Leclerc D, Lejoubioux C, Neguez M, Prévot-Monsacré P, and Cailhol J
- Subjects
- Humans, Pakistan ethnology, Male, Adult, Middle Aged, Young Adult, Female, Prevalence, HIV Infections diagnosis, HIV Infections epidemiology, Health Promotion, Adolescent, Hepatitis C epidemiology, Hepatitis C diagnosis, Mass Screening
- Abstract
Introduction: Pakistan has the second highest prevalence of hepatitis C globally. The Musafir study, set up in 2018 in a Parisian suburb to understand the representations of hepatitis and HIV within the Urdu-speaking, male, migrant community living there, provided an opportunity to think about culturally acceptable health promotion interventions. These included awareness campaigns on hepatitis—which did not cover the question of HIV, considered taboo—, held in a mosque., Purpose of the Research: The aim of this article is to describe the implementation of awareness and testing campaigns within a Pakistani religious and cultural association., Method: A partnership with a Pakistani association that runs a place of worship enabled awareness and testing campaigns for hepatitis and HIV to be carried out, thanks to the involvement of the association’s managers and the imam., Results: Between February and June 2023, 113 people were tested during the five campaigns that were carried out. The population screened consisted almost exclusively of Urdu-speaking men. Anti-HCV antibodies were found in six people, three of whom had already recovered, and two people tested positive for HBV. No cases of HIV were detected., Conclusions: The prevalence of hepatitis C found was 5.3 percent, in line with the prevalence in Pakistan. This experiment highlighted the feasibility conditions of a partnership with a faith-based organization and offers ideas for developing this type of initiative in France.
- Published
- 2024
41. [Affective disorders and antidepressant drugs: Therapeutic innovations].
- Author
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Fakra E, Azorin JM, Adida M, Da Fonseca D, Kaladjian A, and Pringuey D
- Subjects
- Animals, Brain drug effects, Brain physiopathology, Depressive Disorder, Major physiopathology, Humans, Models, Molecular, Neuronal Plasticity drug effects, Neuronal Plasticity physiology, Neurotransmitter Agents physiology, Stress, Psychological complications, Antidepressive Agents therapeutic use, Depressive Disorder, Major drug therapy
- Abstract
As it is the case in other psychiatric disorders, etiopathogenic hypotheses of depression have chiefly been shaped by the fortuitous discovery of antidepressive drugs. Reciprocally, these hypotheses have largely influenced later innovation in therapeutic drugs. In this paper, we aimed to study the development of pharmacological treatments through the different neurobiological and molecular models proposed in depressive illness through the last half-century. We first started by the monoaminergic hypothesis who postulates the existence of a deficit in monoamine transmission (norepinephrine and serotonine). We also discuss of drugs involving other neurotransmitters than the classic monoamines. If this monoaminergic hypothesis has long provided a first level of explanation for the action of antidepressant drugs, limitations have been pointed out. In the last 15 years, another model for the study of depression has clearly emanated: the stress model of depression. A possible reason for the success of this new hypothesis is its ability to provide a satisfying framework to experimental studies, in man and in animal. In this new background, numerous molecular and cellular events have been observed under the influence of stress, and these injuries appear to reverse with antidepressants. It thus seems that antidepressant agents have the ability to opposite the impact of stress through molecular actions, which directly or indirectly influence neuroplasticity., (Copyright © 2010 L'Encéphale. Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
42. [Gene-environment interactions in affective disorders].
- Author
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Azorin JM, Kaladjian A, Fakra E, Da Fonseca D, Adida M, Maurel M, Richieri R, Bottai T, and Pringuey D
- Subjects
- Animals, Bipolar Disorder pathology, Brain pathology, DNA Methylation genetics, Depressive Disorder pathology, Gene Expression genetics, Genetic Association Studies, Histones genetics, Humans, Life Change Events, Polymorphism, Genetic genetics, Proto-Oncogene Mas, Proto-Oncogene Proteins c-fos genetics, RNA, Messenger genetics, Stress, Psychological complications, Transcription Factors genetics, Transcription, Genetic genetics, Bipolar Disorder genetics, Bipolar Disorder psychology, Depressive Disorder genetics, Depressive Disorder psychology, Epigenesis, Genetic genetics, Social Environment
- Abstract
Kindling and behavioural sensitization were probably the first among the animal models of affective disorders, to suggest that genes-environment interactions were likely to be involved in the pathophysiology of these disorders. Cross-sensitization among stressors, drugs of abuse and illness episodes was deemed to be supported by the induction of a series of transcription factors, such as the proto-oncogene c-fos that subsequently alter gene expression by binding at DNA sites and inducing mRNAs for substances that may exert effects over long time periods. This was an anticipation of epigenetics which is currently defined as a functional modification to the DNA that does not involve an alteration of sequence. Epigenetic modifications are most commonly regulated by DNA methylation and histone acetylation which are usually associated with the silencing and activation of gene transcription, respectively. In animal models, it was shown that parents can actively remodel epigenetic marks, and thus affect patterns of gene expression in the offspring, whereas environmental adversity decreases parental investment in the offspring and thus alters phenotypic development. In line with this, some laboratories have sought to identify changes in gene expression in post mortem brain samples of humans with affective disorders. Finally, gene-environment interactions have been directly studied, both in animals and humans, by testing how a functional polymorphism in candidate genes would moderate the influence of stressful life events on behavioural expression. Interesting results have been found and replicated for unipolar depression, however date are scarce for bipolar disorder. Findings from these studies allow the building of more sophisticated models for unipolar and bipolar genetics., (Copyright © 2010 L'Encéphale. Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
43. [Bipolar affective disorders: Models and assessment of psychological treatments].
- Author
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Maurel M, Azorin JM, Adida M, Fakra E, Richieri R, Bottai T, Pringuey D, and Kaladjian A
- Subjects
- Antimanic Agents therapeutic use, Behavior Therapy methods, Bipolar Disorder diagnosis, Bipolar Disorder psychology, Cognitive Behavioral Therapy methods, Combined Modality Therapy, Family Therapy methods, Humans, Life Style, Medication Adherence psychology, Patient Education as Topic methods, Secondary Prevention, Social Environment, Treatment Outcome, Bipolar Disorder therapy, Psychotherapy methods
- Abstract
Psychological therapies dedicated to bipolar patients have attracted major interest and many publications have been devoted to them in the last five years. The efficiency of Psychoeducation, Cognitive and behavioral therapy, Behavioral family therapy and Interpersonal and Social Rhythm Therapy, have specially been focused on. These approaches share a common background of psychoeducation and are closely linked with the transnosographical model from Zubin and Spring as well as basic behavioral and cognitive technical requirements. All these therapies focus on medication adherence, regular lifestyle, early recognition of relapse and early pharmacologic intervention. There are some differences between advantages from each approach, but the overall effect is positive in enhancing medication adherence and preventing manic relapses, and also in preventing depressive episodes and improving quality of life. These robust and corroborating results should probably be integrated in future guidelines for the management of bipolar disorders., (Copyright © 2010 L'Encéphale. Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
44. [Cerebral ischemic infarction in newborn infants. Diagnosis using pulsed and color Doppler imaging].
- Author
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d'Orey MC, Melo MJ, Ramos I, Guimaraes H, Alves AR, Silva JS, Vasconcelos G, Costa A, Silva G, and Santos NT
- Subjects
- Blood Flow Velocity, Cerebral Arteries diagnostic imaging, Cerebral Hemorrhage diagnosis, Cerebrovascular Circulation, Diagnosis, Differential, Humans, Infant, Newborn, Male, Seizures diagnosis, Brain Ischemia diagnostic imaging, Cerebral Infarction diagnostic imaging, Echoencephalography, Ultrasonography, Doppler, Color, Ultrasonography, Doppler, Pulsed
- Abstract
In newborn infant, cerebral infarction is often difficult to distinguish from cerebral hemorrhage, both pathologies being moreover frequently associated. We report a left anterior stroke in a fullterm newborn who had seizures on the third day of life. Ultrasound scanning showed a hyperechogenic zone in the territory of the left anterior cerebral artery. Pulsed and color Doppler imaging showed a decreased blood flow velocity in comparison to the opposite side, thus enabling the diagnosis.
- Published
- 1999
- Full Text
- View/download PDF
45. [The noise in neonatal intensive care units].
- Author
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Guimarães H, Oliveira AM, Spratley J, Mateus M, d'Orey C, Coelho JL, Souto A, and Santos NT
- Subjects
- Humans, Infant, Newborn, Portugal, Intensive Care Units, Neonatal, Noise adverse effects
- Abstract
Background: Noise constitutes a significant problem in Neonatal Intensive Care Units (NICU) because of its potential deleterious effects on the newborn patients and staff. The aim of this study was to evaluate the degree of noise in the NICU of Hospital S João, Oporto, in order to identify its origin and possibility of reducing it., Material and Methods: Measurements of noise were made for 24 hours, between 13 and 14 June 1994, in five different locations inside the NICU, using a slow time constant sonometer., Results: The surrounding noise level changed between 61 and 67 dB (A), with spikes over 100 dB (A)., Conclusions: Our results were similar to those previously reported in the literature. The following measures to reduce the level of noise were taken: 1) reduction of alarm sounds to minimal safe level; 2) replacement of doors; 3) instructions to visitors and staff.
- Published
- 1996
- Full Text
- View/download PDF
46. [Periarteritis nodosa with initial ocular involvement].
- Author
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Pinto Ferreira F, Faria A, and Ganhão F
- Subjects
- Adult, Anti-Inflammatory Agents therapeutic use, Choroiditis drug therapy, Choroiditis etiology, Eye Diseases drug therapy, Fluorescein Angiography, Humans, Male, Polyarteritis Nodosa drug therapy, Prednisolone therapeutic use, Visual Acuity, Eye Diseases etiology, Pigment Epithelium of Eye, Polyarteritis Nodosa diagnosis
- Abstract
Biopsy documented polyarteritis nodosa in a patient who initially presented with ocular involvement. Although uncomun, a wide variety of ocular manifestations can be seen in polyarteritis nodosa. In this case, bilateral choroidal vasculitis was documented, first in the left eye, and one year later, in the right eye. The condition appears to be an acute posterior multifocal placoid pigment epitheliopathy in the left eye. In the fellow eye, serpiginous choroiditis-like lesions were observed.
- Published
- 1995
47. [Estrogen and progesterone receptors in the human placenta].
- Author
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Patricio B
- Subjects
- Cell Nucleus chemistry, Chorion chemistry, Cytosol chemistry, Delivery, Obstetric methods, Evaluation Studies as Topic, Female, Humans, Pregnancy, Placenta chemistry, Receptors, Estrogen analysis, Receptors, Progesterone analysis
- Abstract
The author demonstrates the presence of estrogen and progesterone receptors in the trophoblast. He also refers to their distribution within the cytosol and the nucleus, and also discusses their diversity in the various parts of the placenta. He did not detect any difference between placentas obtained from normal deliveries and those obtained after cesarean deliveries.
- Published
- 1994
48. [Not Available].
- Author
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Coloma Lde S and Mocquot JC
- Published
- 1971
- Full Text
- View/download PDF
49. [Distant results of Marion-Zwillinger operation].
- Author
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Defoort R and De Sy
- Subjects
- Aged, Female, Humans, Male, Methods, Middle Aged, Transplantation, Autologous, Urethra surgery, Urinary Incontinence surgery, Vagina transplantation, Urethral Diseases surgery, Urinary Fistula surgery, Vesicovaginal Fistula surgery
- Published
- 1969
50. [Bilateral polycystic ovaries. A histological study of surgical biopsies done without selection of cases].
- Author
-
Procopio-Valle Y, Chagas WA, de Paola D, Matsui Ade S, and de Andrade CG
- Subjects
- Adult, Aged, Diagnosis, Differential, Female, Humans, Middle Aged, Ovarian Diseases pathology, Ovary pathology, Polycystic Ovary Syndrome pathology
- Published
- 1967
Catalog
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