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The study investigates the antimicrobial efficiency of fungi from the Red Sea in El-Quseir and Sharm El-Sheikh districts. The fungi’s active metabolites were tested for their antibacterial activity against pathogenic germs. The fungi were grown on nutritional agar media and malt extract agar medium. The extracts of marine fungi were also investigated for their cell death potential, using lung carcinoma cells as a cell line. The results of our study demonstrated the strong antimicrobial activity of marine fungi towards both Gramme positive and Gramme negative microorganisms, particularly against Serratia marcenscens and Salmonella. The ethyl acetate extract from El-Quseir (a sand source) and Sharm El-Sheikh (a water source) demonstrated the highest inhibition zones, measuring 37 mm and 35 mm, respectively. The normal cell line (MRC-5) was subjected to cytotoxic effects that demonstrated antibacterial and anticancer properties, while also exerting non-significant toxicity on active concentrations. Comparing petroleum ether, chloroformic, and methanolic extracts to ethyl acetate extract, and our results showed that the latter had the lowest antibacterial activity. Against medically used lung cancer cell lines, marine fungi shown antitumor activity.