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2. [Superacute xenogenic rejection: attempted treatment with anti-idiotypic antibodies].

Author

Salamé E, Chereau C, Calmus Y, Ayani E, Houssin D, and Weill B

Subjects
Acute Disease, Animals, Guinea Pigs, Heart Transplantation mortality, Rats, Transplantation, Heterologous, Antibodies, Anti-Idiotypic therapeutic use, Graft Rejection prevention & control, Heart Transplantation methods
Abstract

Heart xenotransplantation in the guinea-pig to rat model, a highly discordant combination, is invariably followed by a hyperacute rejection of the graft. Preformed IgMs were shown to be responsible for the destruction of the graft by stimulating the complement cascade. We tried to inhibit preformed antibodies, before transplantation, by inducing anti-idiotypic antibodies using autologous Fab' mu specific for guinea-pig endothelial cells. This treatment seems to exert a neutralizing effect on xenogeneic hyperimmunization, against guinea-pig endothelial cells but not against preformed anti-guinea-pig antibodies.

Published
1992

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