1. [In vitro study of the interference of certain food components with the metabolism of aflatoxin B1].
- Author
-
Ngombo M, Rollmann B, de Meester C, and Léonard A
- Subjects
- Animals, Carbolines, Food Handling, Food Preservatives pharmacology, Glutathione metabolism, Mutagenicity Tests, Salmonella typhimurium genetics, Aflatoxin B1 metabolism, Butylated Hydroxytoluene pharmacology, Carcinogens, Environmental metabolism, Food Additives pharmacology, Glutathione drug effects, Harmine analogs & derivatives, Harmine pharmacology, Imidazoles pharmacology, Quercetin pharmacology, Salmonella typhimurium drug effects, Sulfites pharmacology, beta-Naphthoflavone pharmacology
- Abstract
Some compounds naturally present in food (quercetin, beta-naphthoflavone), used as food additives (butylated hydroxytoluene, sodium sulfite) or resulting from the way they were cooked (2-aminodipyrido [1,2-a; 3', 2'-d] imidazole, norharmane) can interfere with AFB1 metabolism. These interferences have been studied in vitro by evaluating the production of adducts to glutathione and by the Ames test on Salmonella typhimurium. Whereas all compounds produced a drastic decrease of the mutagenic activity, the first three only (quercetin, beta-naphthoflavone, butylated hydroxytoluene) interfered with the production of the adducts to glutathione.
- Published
- 2000