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Your search keyword '"C. Darcissac"' showing total 4 results
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4 results on '"C. Darcissac"'

1. [Prospective risk analysis in a retrocession unit: Focus on drug dispensation process]

Author

C, Darcissac, L, Duvert, D, Hoegy, M, Chappuy, C, Pivot, and A, Janoly-Dumenil

Subjects
Hospitals, University, Humans, Medication Errors, France, Healthcare Failure Mode and Effect Analysis, Prospective Studies, Medication Systems, Pharmacy Service, Hospital, Risk Assessment
Abstract

Failure mode effect analysis (FMEA) improves safety in the drug life cycle. As the drug dispensation by hospital's pharmacy can be at risk, the FMEA tool has been used to evaluate and enhance the process.After detailing the process, a first FMEA has been run in 2015. Corrective actions were implemented every time criticality indexes (CI) were above 15. One year later, we have evaluated potential impacts of these actions by running a new FMEA.In 2015, 11 failure modes were prioritized (CI15) and the total CI for the overall process was 397. Corrective actions were implemented and one year later this amount has decreased by 14% (340) with 6 failure modes still prioritized. Thus, thanks to the FMEA, risks could be identified in year "y", they were taken into account and corrected and then effectively reassessed in year "y+1".This study showed us the interest of performing FMEA analysis in the drug dispensation process by hospital. The renewal of this risk analysis after a year helped us to monitor corrective actions, to evaluate their effectiveness and to improve safety. Finally, FMEA seems to be an effective way to steer the drug dispensation process.

Published
2019

2. [Lower limb edema during valpromide treatment: case report and literature review]

Author

L, Gabriel, C, Darcissac, S, Goutelle, P, Sève, T, Vial, and B, de La Gastine

Subjects
Aged, 80 and over, Lower Extremity, Withholding Treatment, Furosemide, Valproic Acid, Edema, Humans, Anticonvulsants, Female
Abstract

Valpromide and sodium divalproate are indicated in the treatment of maniac episodes of bipolar disorder. These drugs are metabolized into valproic acid. The occurrence of peripheral edema has been described as a very rare adverse reaction of those drugs.We report the case of a patient treated with valpromide who presented edema of the lower limbs. The increase in furosemide dose allowed regression of edema, and valpromide discontinuation resulted in rapid normalization. Recurrence of mood disorders led to the reintroduction of valpromide, which was associated with recurrence of edema. The definitive withdrawal of valpromide resulted in resolution of edema.Edema of the lower limbs can be induced by valproate. The mechanism of this reaction is unknown. These edema appear to be reversible upon discontinuation of the drug. Clinicians should be aware of a possible relationship between valproate-derived drugs and peripheral edema.

Published
2014

3. [Prospective risk analysis in a retrocession unit: Focus on drug dispensation process].

Author

Darcissac C, Duvert L, Hoegy D, Chappuy M, Pivot C, and Janoly-Dumenil A

Subjects
France, Hospitals, University organization & administration, Humans, Medication Errors prevention & control, Medication Systems organization & administration, Prospective Studies, Healthcare Failure Mode and Effect Analysis organization & administration, Medication Errors statistics & numerical data, Medication Systems statistics & numerical data, Pharmacy Service, Hospital statistics & numerical data, Risk Assessment
Abstract

Objectives: Failure mode effect analysis (FMEA) improves safety in the drug life cycle. As the drug dispensation by hospital's pharmacy can be at risk, the FMEA tool has been used to evaluate and enhance the process., Methods: After detailing the process, a first FMEA has been run in 2015. Corrective actions were implemented every time criticality indexes (CI) were above 15. One year later, we have evaluated potential impacts of these actions by running a new FMEA., Results: In 2015, 11 failure modes were prioritized (CI>15) and the total CI for the overall process was 397. Corrective actions were implemented and one year later this amount has decreased by 14% (340) with 6 failure modes still prioritized. Thus, thanks to the FMEA, risks could be identified in year "y", they were taken into account and corrected and then effectively reassessed in year "y+1"., Conclusion: This study showed us the interest of performing FMEA analysis in the drug dispensation process by hospital. The renewal of this risk analysis after a year helped us to monitor corrective actions, to evaluate their effectiveness and to improve safety. Finally, FMEA seems to be an effective way to steer the drug dispensation process., (Copyright © 2019 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.)

Published
2020
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4. [Lower limb edema during valpromide treatment: case report and literature review].

Author

Gabriel L, Darcissac C, Goutelle S, Sève P, Vial T, and de La Gastine B

Subjects
Aged, 80 and over, Edema diagnosis, Edema drug therapy, Female, Furosemide therapeutic use, Humans, Valproic Acid adverse effects, Withholding Treatment, Anticonvulsants adverse effects, Edema chemically induced, Lower Extremity, Valproic Acid analogs & derivatives
Abstract

Introduction: Valpromide and sodium divalproate are indicated in the treatment of maniac episodes of bipolar disorder. These drugs are metabolized into valproic acid. The occurrence of peripheral edema has been described as a very rare adverse reaction of those drugs., Case Report: We report the case of a patient treated with valpromide who presented edema of the lower limbs. The increase in furosemide dose allowed regression of edema, and valpromide discontinuation resulted in rapid normalization. Recurrence of mood disorders led to the reintroduction of valpromide, which was associated with recurrence of edema. The definitive withdrawal of valpromide resulted in resolution of edema., Conclusion: Edema of the lower limbs can be induced by valproate. The mechanism of this reaction is unknown. These edema appear to be reversible upon discontinuation of the drug. Clinicians should be aware of a possible relationship between valproate-derived drugs and peripheral edema., (Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.)

Published
2015
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