1. [Radiation-induced superficial fibrosis and TGF-alpha 1].
- Author
-
Martin M, Delanian S, Sivan V, Vozenin-Brotons MC, Reisdorf P, Lawrence D, and Lefaix JL
- Subjects
- Animals, Dose-Response Relationship, Radiation, Fibroblasts pathology, Fibroblasts radiation effects, Fibrosis pathology, Humans, Radiation Injuries prevention & control, Transforming Growth Factor beta antagonists & inhibitors, Transforming Growth Factor beta1, Radiation Injuries pathology, Transforming Growth Factor beta physiology
- Abstract
Radiation-induced fibrosis is a late sequela of both therapeutic and accidental irradiations, which has been described in various tissues, including the lung, liver, kidney and skin. This review presents different aspects of superficial radiation-induced fibrosis, such as clinical observations, histological changes, cellular and molecular regulations, and medical management. Recent evidence on the critical role played by TGF-beta 1 in the initiation, development and persistence of fibrosis are discussed, as well as the possibility that this cytokine may constitute a specific target for antifibrotic agents.
- Published
- 2000
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