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19. Liste des auteurs

Author

Baulot, Emmanuel, Baverel, Laurent, Berhouet, Julien, Boileau, Pascal, Bonnevialle, Nicolas, Chelli, Mikael, Clavert, Philippe, Collin, Philippe, Collotte, Philippe, Corvec, Stéphane, de Wilde, Lieven, Egger, Marlen, Farron, Alain, Favard, Luc, Ferrand, Matthieu, Flurin, Pierre-Henri, Gain, S., Gallinet, David, Gauci, Marc-Olivier, Gonzalez, Jean-François, HERVÉ, Anthony, Jacquot, Adrien, Joudet, Thierry, Lädermann, Alexandre, Lévigne, Christophe, Mansat, Pierre, Mazaleyrat, Matthieu, Meynard, Timon, Nérot, Cécile, Neyton, Lionel, Peduzzi, Lisa, Sirveaux, François, Spiry, Clément, Teissier, Jacques, Teissier, Philippe, Terrier, Alexandre, Thomazeau, Hervé, Tronchot, A., Valenti, Philippe, Verdonk, René, Verstuyft, Lotte, Walch, Gilles, and Werthel, Jean-David

Published
2020
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23. Early-onset neonatal infection: Assessment of professional practices in 14 maternity wards in the Île-de-France region in 2013

Author

Sikias, Patrick, Parmentier, Cyrielle, Imbert, Patrick, Rajguru, Mandovi, Chavet, M. S., Coquery, Sarah, Foix-L'Hélias, Laurence, Boileau, Pascal, Hôpital privé d’Antony, Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut hospitalier Franco-Britannique [Levallois-Perret], Risques cliniques et sécurité en santé des femmes et en santé périnatale (RISCQ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and CHI Poissy-Saint-Germain

Subjects
Adult, Gastric Juice, Bacteria, [SDV]Life Sciences [q-bio], Infant, Newborn, Bacterial Infections, Infectious Disease Transmission, Vertical, Anti-Bacterial Agents, C-Reactive Protein, Pregnancy, Practice Guidelines as Topic, Humans, Female, France, Guideline Adherence, Prospective Studies, Practice Patterns, Physicians', Pregnancy Complications, Infectious, Hospital Units
Abstract

International audience; Introduction: Early-onset neonatal infection remains a major cause of morbidity and mortality in neonates. Both universal vaginal screening for group-B streptococcus (GBS) and intrapartum antibiotic prophylaxis have decreased the incidence of early-onset GBS disease. Almost 12 years after the implementation of the French recommendations, we assessed the practices around screening, diagnosis, and treatment of early-onset neonatal infection in the Île-de-France region. Patients and methods: We conducted a prospective, multicenter, observational study in 14 volunteer maternity wards from 18 to 31 March 2013. All live newborn infants delivered at 35 gestational weeks or more were eligible. Maternal, obstetrical, and neonatal characteristics were collected, as well as the management of suspected early-onset neonatal infections. Results: A total of 1194 mothers and 1217 neonates were included. Among the latter, 54% had bacteriological samplings at birth, with at least a gastric aspirate. Bacteriological samples were collected at birth in 85% of cases based on major or minor anamnestic infection criteria defined by the French National Authority for Health in 2002. In addition, 26% of neonates had at least one blood sample taken. Antibiotic treatment was administered in 4% of the infants with cefotaxime administered in two thirds of cases. Conclusion: An update of the French guidelines for the management of early-onset neonatal infections is required in order to improve targeting of newborn infants suspected of having an infection and to optimize the antibiotics administered. Moreover, the role of bacteriological sampling at birth needs to be clarified.

Published
2015

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