1. Planification de la radiothérapie du cancer de la prostate par l’imagerie par résonance magnétique
- Author
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David Pasquier, E. Rault, F. Crop, L. Vanquin, A. Wagner, Thomas Lacornerie, Juha Korhonen, Nick Reynaert, J. Laffarguette, Christine Boydev, HUS Cancercentrum, Avdelningen för cancersjukdomar, Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Pseudo-CT (Pseudo-Computerized Tomography) ,Radiotherapy ,PSEUDO-CT ,SEQUENCES ,[SDV]Life Sciences [q-bio] ,3122 Cancers ,3126 Surgery, anesthesiology, intensive care, radiology ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,VERIFICATION ,030220 oncology & carcinogenesis ,Radiology, Nuclear Medicine and imaging ,MRI-ONLY RADIOTHERAPY ,Elastic registration ,MRI ,GENERATION - Abstract
Purpose.-Magnetic resonance imaging (MRI) plays an increasing role in radiotherapy dose planning. Indeed, MRI offers superior soft tissue contrast compared to computerized tomography (CT) and therefore could provide a better delineation of target volumes and organs at risk than CT for radiotherapy. Furthermore, an MRI-only radiotherapy workflow would suppress registration errors inherent to the registration of MRI with CT. However, the estimation of the electronic density of tissues using MRI images is still a challenging issue. The purpose of this work was to design and evaluate a pseudo-CT generation method for prostate cancer treatments. Materials and methods.-A pseudo-CT was generated for ten prostate cancer patients using an elastic deformation based method. For each patient, dose delivered to the patient was calculated using both the planning CT and the pseudo-CT. Dose differences between CT and pseudo-CT were investigated. Results.-Mean dose relative difference in the planning target volume is 0.9% on average and ranges from 0.1% to 1.7%. In organs at risks, this value is 1.8%, 0.8%, 0.8% and 1% on average in the rectum, the right and left femoral heads, and the bladder respectively. Conclusio.-The dose calculated using the pseudo-CT is very close to the dose calculated using the CT for both organs at risk and PTV. These results confirm that pseudo-CT images generated using the proposed method could be used to calculate radiotherapy treatment doses on MRI images. (C) 2019 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
- Published
- 2019