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5. Prescription en odontologie: le point sur les interactions médicamenteuses.

Author

Malthiéry, Ève, Clarivet, Béatrice, Fauroux, Marie-Alix, Hillaire-Buys, Dominique, and Torres, Jacques-Henri

Abstract

Copyright of Médecine Buccale Chirurgie Buccale is the property of EDP Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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6. [Quantitative structure-hypoglycemic activity relationships of some thiazolidine and imidazolidine-2,4-diones].

Author

de Lima JG, Galdino SL, Pitta Ida R, Catanho MT, Perrissin M, and Luu-Duc C

Subjects
Animals, Female, Male, Mice, Structure-Activity Relationship, Hypoglycemia chemically induced, Imidazoles pharmacology, Thiazoles pharmacology
Abstract

Quantitative structure-activity relationships are described for twenty six title compounds. Five compounds exhibit a significant hypoglycemic activity like insulin used as standard. The aim of the present paper is to investigate the contribution of the different substituents in the biological activity. The application of Fujita-Ban and Hansch models has shown that lipophilic and electronic parameters seem to be the best explanation of variance of biological data.

Published
1993

7. [Management of toxicities of BRAF inhibitors and MEK inhibitors in advanced melanoma]

Author

Vincent, Sibaud, Lilian, Baric, Alain, Cantagrel, Mario, Di Palma, Stéphane, Ederhy, Michel, Paques, and Gabriel, Perlemuter

Subjects
Mitogen-Activated Protein Kinase Kinases, Proto-Oncogene Proteins B-raf, Sulfonamides, Pyridones, Imidazoles, Pyrimidinones, Drug Combinations, Piperidines, Vemurafenib, Antineoplastic Combined Chemotherapy Protocols, Mutation, Oximes, Azetidines, Humans, Benzimidazoles, Carbamates, Melanoma
Abstract

Major therapeutic advances have been made recently in the treatment of metastatic melanoma, due to the development of targeted therapies, namely BRAF and MEK inhibitors, in patients with BRAF V600 mutation. Combinations of vemurafenib+cobimetinib, dabrafenib+trametinib, et encorafenib+binimetinib, evaluated in coBRIM, COMBI-d/COMBI-v and COLUMBUS trials respectively have been approved in this indication. Toxicities induced by combination therapies are different from those reported with monotherapies, in terms of frequency and intensity. Physicians who treat melanoma patients thus face news issues relating to prevention, detection and treatment of these adverse events. This paper summarizes tolerance data from the three pivotal trials (coBRIM, COMBI-v and COLUMBUS) and issues recommendations for the specific management of main toxicities, based on experts' opinion. We discuss dermatological, ophthalmological, cardiovascular, digestive, musculoskeletal, renal and general toxicities and propose a timetable for examinations to be performed before and during treatment.

Published
2020

9. [Quantitative structure-hypoglycemic activity relationships of some thiazolidine and imidazolidine-2,4-diones]

Author

J G, de Lima, S L, Galdino, I da R, Pitta, M T, Catanho, M, Perrissin, and C, Luu-Duc

Subjects
Male, Mice, Structure-Activity Relationship, Thiazoles, Imidazoles, Animals, Female, Hypoglycemia
Abstract

Quantitative structure-activity relationships are described for twenty six title compounds. Five compounds exhibit a significant hypoglycemic activity like insulin used as standard. The aim of the present paper is to investigate the contribution of the different substituents in the biological activity. The application of Fujita-Ban and Hansch models has shown that lipophilic and electronic parameters seem to be the best explanation of variance of biological data.

Published
1993