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1. Choc anaphylactique à un produit de contraste iodé : intérêt du bilan allergologique à propos d’un cas

Author

Halna du Fretay, X., Gaillet, G., Hoarau, C., and Blanchard-Lemoine, B.

Subjects
*ANAPHYLAXIS, *IODINE, *CONTRAST media, *ALLERGIES, *ALLERGENS, *CORONARY angiography
Abstract

Abstract: Anaphylactoid reactions to iodine contrast media are rare but serious, possibly life-threatening and calling an appropriate and urgent care. The physiopathological mechanism of these reactions remains to be fully elucidated. This reaction is still mostly called “pseudoallergic” in the literature. However, recent papers emphasise that a true allergic process is more frequent than previously expected. They also insist on the interest of running allergy tests including skin testing. We report the case of an anaphylactic shock to iodine contrast media, occurring during coronary angiography. We performed an allergy check-up and found the culprit allergen. We also evidenced a cross-reaction to another contrast media from the similar group. On the other hand, there was no reaction to contrast media of other types. With these results, another coronary angiography could be performed without any adverse event. When hypersensitivity reactions to iodine contrast media occur, it is mandatory to perform a complete allergy check-up. This will help determine the precise mechanism of the reaction and find the culprit allergen. [Copyright &y& Elsevier]

Published
2012
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2. From exposure to allergen to onset of an allergic disease

Author

Vervloet, D.

Subjects
*ALLERGENS, *ASTHMA, *ALLERGIES
Abstract

In this paper, special consideration will be given to the following points:

  • Is there a causal relationship between exposure to aeroallergens and allergic sensitization?
  • Is there a causal relationship between sensitization and occurrence of allergic disease?
  • Is there a causal relationship between exposure to allergen and occurrence of allergic disease?
  • Are symptom severity and the morbidity of allergic diseases related to the level of exposure to environmental allergen?
    • A review of the literature indicates that, in most circumstances, there is a significant relationship between the level of exposure and the degree of sensitization to a given allergen. However, recent studies indicate that early contact with dogs and cats may in fact prevent sensitization in some children who are at risk. On the other hand, there is a relationship between sensitization and the occurrence of allergic disease, but in general there is no causal relationship between the degree of exposure to allergen and the occurrence of disease. In contrast, the severity of symptoms and the morbidity of allergic diseases are related to the level of exposure to environmental allergens [Copyright &y& Elsevier]

    Published
    2003