1. Coronary heart disease risk factor levels in eastern and western Finland from 1980 to 2011 in the cardiovascular risk in Young Finns study
- Author
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Leena Taittonen, Katja Pahkala, Nina Hutri-Kähönen, Costan G. Magnussen, Jorma Viikari, Lauri Vähämurto, Risto Telama, Markus Juonala, Terho Lehtimäki, Tapani Rönnemaa, Tomi Laitinen, Eero Jokinen, Mika Kähönen, Päivi Tossavainen, Olli T. Raitakari, Lastentautien yksikkö, Children's Hospital, Clinicum, University of Helsinki, and HUS Children and Adolescents
- Subjects
Blood Glucose ,Male ,0301 basic medicine ,Blood Pressure ,Coronary Disease ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Risk Factors ,Medicine ,Longitudinal cohort ,Child ,Finland ,Atherosclerosis precursors ,Metabolic Syndrome ,education.field_of_study ,Anthropometry ,Geography ,Incidence (epidemiology) ,Middle Aged ,Cardiovascular disease ,Adulthood ,16. Peace & justice ,NORTH-KARELIA-PROJECT ,Cholesterol ,Cardiovascular Diseases ,Child, Preschool ,Hypertension ,Population study ,Female ,MEDIA THICKNESS ,Cardiology and Cardiovascular Medicine ,Adult ,Adolescent ,MIGRATION ,Population ,Risk Assessment ,SECULAR TRENDS ,03 medical and health sciences ,Chd mortality ,Humans ,Risk factor ,SHORT STATURE ,education ,Life Style ,DECLINE ,business.industry ,MORTALITY ,ta3121 ,INTIMA ,Coronary heart disease ,Fatty Liver ,030104 developmental biology ,Social Class ,3121 General medicine, internal medicine and other clinical medicine ,Longitudinal ,FOLLOW-UP ,business ,Chd risk ,Follow-Up Studies ,Demography - Abstract
Background and aims In the 1960s and 1970s, Finland, mortality due to coronary heart disease (CHD) was over 30% higher among Finns residing in the east of the country compared with those residing in the west. Today, CHD mortality remains 20% higher among eastern Finns. The higher incidence of CHD mortality among eastern Finns has largely been explained by higher risk factor levels. Using a unique longitudinal cohort, we aimed to determine if participants who resided in eastern Finland during childhood had higher CHD risk factors in adulthood and from childhood to adulthood. Methods The study population included 2063 participants of the Cardiovascular Risk in Young Finns Study, born during the period 1962–1977, with risk factor data available from baseline (1980) when participants were aged 3–18 years, and had risk factor data collected again in adulthood (2011) when aged 34–49 years. Results Adult CHD risk factor profile was similar for those who resided in eastern or western Finland in childhood. Over life-course from 1980 to 2011, those subjects with childhood residency in eastern Finland had, on average, higher systolic (p = 0.006) and diastolic (p = 0.0009) blood pressures, total (p = 0.01) and LDL-cholesterol (p = 0.01), triglycerides (p = 0.04), apoB (p = 0.02), and serum glucose (p Conclusions Our sample of adult Finns aged 34–49 years had a similar CHD risk factor profile irrespective of whether they resided in eastern or western Finland during their childhood. However, when considering participants risk factor profiles over a 31-year period, those who resided in eastern Finland in childhood were associated with a less favorable CHD risk factor profile than those who resided in western Finland in childhood. The observed differences suggest that future CHD mortality might remain higher in eastern Finland compared with western Finland.
- Published
- 2019