1. Serial fractional exhaled nitric oxide measurements at and off work may help to identify immunologic occupational asthma in cases with complex exposures.
- Author
-
van Kampen, V., Eisenhawer, C., Brüning, T., and Merget, R.
- Subjects
- *
OCCUPATIONAL asthma , *NITRIC oxide , *WORK measurement , *RESPIRATORY obstructions , *HEXAMETHYLENE diisocyanate , *ATOPY - Abstract
Serial measurements of fractional exhaled nitric oxide (FeNO) at home and at work have been described to provide complementary information for the diagnosis of occupational asthma (OA) when specific inhalation challenge (SIC) is missing or doubtful. We describe two cases in which serial FeNO measurements enabled the detection of probable OA after complex exposures. A 25-year-old industrial painter with exposure to a variety of paints suffered from work-related airway symptoms for five years. Lung function was normal, and she was not atopic. SIC with hexamethylene diisocyanate was negative. A 47-year-old sign maker (screen printing, foils) suffering from work-related dyspnoea for seven years. Moderate airway obstruction, but no atopy was detectable. Due to the complex exposures SIC was not performed. Both patients performed FeNO measurements once daily during a 2–week-holiday and a subsequent 2–week-work period. In both cases elevated baseline FeNO decreased to normal (25 ppb) during holidays and increased after resuming work (case 1: 125 ppb, case 2: 45 ppb). • In the case of complex exposure, the specific challenge test, which is the gold standard, is often not possible. • Serial measurements of fractional nitric oxide (FeNO) at home and at work may help to confirm an immunological mechanism. • Compared to portable spirometry (FEV 1), FeNO measurements are easy to perform and independent of patients' motivation. • FeNO measurements should not be used as single diagnostic criterion, but always together with other diagnostic tools. • A lack of FeNO increase does not exclude the existence of occupational asthma. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF