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2 results on '"stat3-amyloid β"'

1. Identification and characterization of Prokineticin receptor 2 splicing variant and its modulation in an animal model of Alzheimer's disease.

Author

Lattanzi, Roberta, Maftei, Daniela, Fullone, Maria Rosaria, and Miele, Rossella

Abstract

Highlights • The rat PKR2 mRNA exists in two splicing variant, PKR2 wt and TM 4–7. • TM 4–7 lacks the N-terminal region comprising the first three transmembrane helics. • TM 4–7 is expressed in rat hippocampus. • TM 4–7 heterodimerizes with PKR2 and couples to Gα q and Gα s but not to Gα i. • TM 4–7 inhibits STAT3 activation in hippocampus of Aβ 1–42 injected rats. [ABSTRACT FROM AUTHOR]

Published
2019
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2. Identification and characterization of prokineticin receptor 2 splicing variant and its modulation in an animal model of alzheimer's disease

Author

Roberta Lattanzi, Rossella Miele, Daniela Maftei, and Maria Rosaria Fullone

Subjects
Male, STAT3 Transcription Factor, Receptors, Peptide, prokineticin, prokineticin receptor 2, stat3-amyloid β, ubiquitin split system, yeast, endocrinology, neurology, endocrine and autonomic systems, cellular and molecular neuroscience, Computational biology, Disease, Biology, Hippocampus, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, Animal model, Alzheimer Disease, Animals, Protein Isoforms, Amyloid beta-Peptides, Prokineticin receptor 2, General Medicine, Prokineticin, Peptide Fragments, Up-Regulation, Disease Models, Animal, Suppressor of Cytokine Signaling 3 Protein, RNA splicing, Identification (biology), Signal Transduction
Published
2019

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