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Multipla skleroza (MS)je kronična, demijelinizirajuća bolest za koju se dugo smatralo da ju ne prati bol. Cilj ovoga istraživanja bio je utvrditi učestalost i trajanje bolnih stanja u bolesnika s MS liječenih na Klinici za neurologiju, KB «Sestre milosrdnice». U razdoblju od tri godine obuhvatili smo 280 bolesnika. Sto šezdeset četiri bolesnika (60%) je imalo akutni ili kronični bolni sindrom. šest bolesnika (2.1%) s akutnim bolnim stanjem imalo je paroksizmalne bolne atake u području trigeminalnog živca. Kronični bolni sindrom dijagnosticiran je u 55% (n=154) bolesnika i uključivao je razne oblike glavobolje (38%), bol u vratnom ili lumbosakralnom dijelu kralješnice (58%) te bolne spazme u 4% bolesnika. Na temelju rezultata ove retrospektivne studije vidljivo je da su akutni i kronični bolni sindromi prisutni u velikom broju bolesnika oboljelih od MS te da terapija svakog bolesnika mora biti individualizirana., Multiple sclerosis is a disease of the central nervous system, beginning most often in late adolescence and early adult life, and expressing itself by recurrent attacks of spinal cord, brainstem, cerebellar, optic nerve and cerebral dysfunction, the result of foci of myelinated fiber destruction. In this retrospective study, 280 patients hospitalized at University Department of Neurology during the last three years were evaluated. Study results showed 104 (60%) patients to have suffered either acute or chronic pain syndrome at some time during the course of disease. Six (2.1%) patients with acute pain syndromes had episodes of paroxysmal pain attacks in the trigeminal nerve distribution. Chronic pain syndromes, present for a mean duration of 4.2 years occurred in 154 (55%) patients and included headache in 38% , cervical and lumbosacral syndrome in 58%, and painful leg spasms in 4% of study patients.

Multiple sclerosis is a disease of the central nervous system, beginning most often in late adolescence and early adult life, and expressing itself by recurrent attacks of spinal cord, brainstem, cerebellar, optic nerve and cerebral dysfunction, the result of foci of myelinated fiber destruction. In this retrospective study, 280 patients hospitalized at University Department of Neurology during the last three years were evaluated. Study results showed 104 (60%) patients to have suffered either acute or chronic pain syndrome at some time during the course of disease. Six (2.1%) patients with acute pain syndromes had episodes of paroxysmal pain attacks in the trigeminal nerve distribution. Chronic pain syndromes, present for a mean duration of 4.2 years occurred in 154 (55%) patients and included headache in 38% , cervical and lumbosacral syndrome in 58%, and painful leg spasms in 4% of study patients.